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UniProtKB - P77561 (YDEP_ECOLI)

Entry version 148 (07 Oct 2020)
Sequence version 1 (01 Feb 1997)
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Protein

Protein YdeP

Gene

ydeP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably involved in acid resistance.2 Publications

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi49Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi52Iron-sulfur (4Fe-4S)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • response to acidic pH Source: EcoCyc
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:G6791-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein YdeP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ydeP
Ordered Locus Names:b1501, JW1495
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000632271 – 759Protein YdePAdd BLAST759

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P77561

PRoteomics IDEntifications database

More...PRIDEi		P77561

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By EvgA.2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4260213, 9 interactors
850416, 1 interactor

Database of interacting proteins

More...DIPi		DIP-28057N

Protein interaction database and analysis system

More...IntActi		P77561, 11 interactors

STRING: functional protein association networks

More...STRINGi		511145.b1501

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0243, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000422_16_1_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P77561

Database for complete collections of gene phylogenies

More...PhylomeDBi		P77561

Family and domain databases

Conserved Domains Database

More...CDDi		cd02787, MopB_CT_ydeP, 1 hit
cd02767, MopB_ydeP, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009010, Asp_de-COase-like_dom_sf
IPR037951, MopB_CT_YdeP
IPR006656, Mopterin_OxRdtase
IPR010046, Mopterin_OxRdtse_a_bac
IPR041953, YdeP_MopB

The PANTHER Classification System

More...PANTHERi		PTHR43105:SF4, PTHR43105:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00384, Molybdopterin, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50692, SSF50692, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01701, Fdhalpha-like, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P77561-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKKIESYQG AAGGWGAVKS VANAVRKQMD IRQDVIAMFD MNKPEGFDCP 
        60         70         80         90        100
GCAWPDPKHS ASFDICENGA KAIAWEVTDK QVNASFFAEN TVQSLLTWGD 
       110        120        130        140        150
HELEAAGRLT QPLKYDAVSD CYKPLSWQQA FDEIGARLQS YSDPNQVEFY 
       160        170        180        190        200
TSGRTSNEAA FLYQLFAREY GSNNFPDCSN MCHEPTSVGL AASIGVGKGT 
       210        220        230        240        250
VLLEDFEKCD LVICIGHNPG TNHPRMLTSL RALVKRGAKM IAINPLQERG 
       260        270        280        290        300
LERFTAPQNP FEMLTNSETQ LASAYYNVRI GGDMALLKGM MRLLIERDDA 
       310        320        330        340        350
ASAAGRPSLL DDEFIQTHTV GFDELRRDVL NSEWKDIERI SGLSQTQIAE 
       360        370        380        390        400
LADAYAAAER TIICYGMGIT QHEHGTQNVQ QLVNLLLMKG NIGKPGAGIC 
       410        420        430        440        450
PLRGHSNVQG DRTVGITEKP SAEFLARLGE RYGFTPPHAP GHAAIASMQA 
       460        470        480        490        500
ICTGQARALI CMGGNFALAM PDREASAVPL TQLDLAVHVA TKLNRSHLLT 
       510        520        530        540        550
ARHSYILPVL GRSEIDMQKN GAQAVTVEDS MSMIHASRGV LKPAGVMLKS 
       560        570        580        590        600
ECAVVAGIAQ AALPQSVVAW EYLVEDYDRI RNDIEAVLPE FADYNQRIRH 
       610        620        630        640        650
PGGFHLINAA AERRWMTPSG KANFITSKGL LEDPSSAFNS KLVMATVRSH 
       660        670        680        690        700
DQYNTTIYGM DDRYRGVFGQ RDVVFMSAKQ AKICRVKNGE RVNLIALTPD 
       710        720        730        740        750
GKRSSRRMDR LKVVIYPMAD RSLVTYFPES NHMLTLDNHD PLSGIPGYKS 

IPVELEPSN
Length:759
Mass (Da):83,495
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4DE7C14068FB66DD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74574.1
AP009048 Genomic DNA Translation: BAA15174.1

Protein sequence database of the Protein Information Resource

More...PIRi		H64903

NCBI Reference Sequences

More...RefSeqi		NP_416018.1, NC_000913.3
WP_000726691.1, NZ_SSZK01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC74574; AAC74574; b1501
BAA15174; BAA15174; BAA15174

Database of genes from NCBI RefSeq genomes

More...GeneIDi		946055

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW1495
eco:b1501

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.765

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74574.1
AP009048 Genomic DNA Translation: BAA15174.1
PIRiH64903
RefSeqiNP_416018.1, NC_000913.3
WP_000726691.1, NZ_SSZK01000001.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4260213, 9 interactors
850416, 1 interactor
DIPiDIP-28057N
IntActiP77561, 11 interactors
STRINGi511145.b1501

Proteomic databases

PaxDbiP77561
PRIDEiP77561

Genome annotation databases

EnsemblBacteriaiAAC74574; AAC74574; b1501
BAA15174; BAA15174; BAA15174
GeneIDi946055
KEGGiecj:JW1495
eco:b1501
PATRICifig|1411691.4.peg.765

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB3559

Phylogenomic databases

eggNOGiCOG0243, Bacteria
HOGENOMiCLU_000422_16_1_6
InParanoidiP77561
PhylomeDBiP77561

Enzyme and pathway databases

BioCyciEcoCyc:G6791-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P77561

Family and domain databases

CDDicd02787, MopB_CT_ydeP, 1 hit
cd02767, MopB_ydeP, 1 hit
InterProiView protein in InterPro
IPR009010, Asp_de-COase-like_dom_sf
IPR037951, MopB_CT_YdeP
IPR006656, Mopterin_OxRdtase
IPR010046, Mopterin_OxRdtse_a_bac
IPR041953, YdeP_MopB
PANTHERiPTHR43105:SF4, PTHR43105:SF4, 1 hit
PfamiView protein in Pfam
PF00384, Molybdopterin, 1 hit
SUPFAMiSSF50692, SSF50692, 1 hit
TIGRFAMsiTIGR01701, Fdhalpha-like, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYDEP_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P77561
Secondary accession number(s): P78160
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: February 1, 1997
Last modified: October 7, 2020
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
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