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Protein

Propionate--CoA ligase

Gene

prpE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of propionyl-CoA from propionate and CoA. Also converts acetate to acetyl-CoA but with a lower specific activity (By similarity).By similarity

Catalytic activityi

ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA.

Pathwayi: propanoate degradation

This protein is involved in the pathway propanoate degradation, which is part of Organic acid metabolism.
View all proteins of this organism that are known to be involved in the pathway propanoate degradation and in Organic acid metabolism.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • propionate-CoA ligase activity Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6200-MONOMER
MetaCyc:G6200-MONOMER
UniPathwayiUPA00946

Names & Taxonomyi

Protein namesi
Recommended name:
Propionate--CoA ligase (EC:6.2.1.17)
Alternative name(s):
Propionyl-CoA synthetase
Gene namesi
Name:prpE
Synonyms:yahU
Ordered Locus Names:b0335, JW0326
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13604 prpE

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001931881 – 628Propionate--CoA ligaseAdd BLAST628

Proteomic databases

PaxDbiP77495
PRIDEiP77495

Interactioni

Protein-protein interaction databases

BioGridi4259811, 7 interactors
IntActiP77495, 7 interactors
STRINGi316407.85674477

Structurei

3D structure databases

ProteinModelPortaliP77495
SMRiP77495
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108IQF Bacteria
COG0365 LUCA
HOGENOMiHOG000229981
InParanoidiP77495
KOiK01908
OMAiGFAAHNL
PhylomeDBiP77495

Family and domain databases

InterProiView protein in InterPro
IPR032387 ACAS_N
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR012694 Propion_PrpE
PfamiView protein in Pfam
PF16177 ACAS_N, 1 hit
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
TIGRFAMsiTIGR02316 propion_prpE, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

P77495-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSEFYQRS INEPEQFWAE QARRIDWQTP FTQTLDHSNP PFARWFCEGR
60 70 80 90 100
TNLCHNAIDR WLEKQPEALA LIAVSSETEE ERTFTFRQLH DEVNAVASML
110 120 130 140 150
RSLGVQRGDR VLVYMPMIAE AHITLLACAR IGAIHSVVFG GFASHSVAAR
160 170 180 190 200
IDDAKPVLIV SADAGARGGK IIPYKKLLDD AISQAQHQPR HVLLVDRGLA
210 220 230 240 250
KMARVSGRDV DFASLRHQHI GARVPVAWLE SNETSCILYT SGTTGKPKGV
260 270 280 290 300
QRDVGGYAVA LATSMDTIFG GKAGSVFFCA SDIGWVVGHS YIVYAPLLAG
310 320 330 340 350
MATIVYEGLP TWPDCGVWWT IVEKYQVSRM FSAPTAIRVL KKFPTAEIRK
360 370 380 390 400
HDLSSLEVLY LAGEPLDEPT ASWVSNTLDV PVIDNYWQTE SGWPIMAIAR
410 420 430 440 450
GLDDRPTRLG SPGVPMYGYN VQLLNEVTGE PCGVNEKGML VVEGPLPPGC
460 470 480 490 500
IQTIWGDDGR FVKTYWSLFS RPVYATFDWG IRDADGYHFI LGRTDDVINV
510 520 530 540 550
AGHRLGTREI EESISSHPGV AEVAVVGVKD ALKGQVAVAF VIPKESDSLE
560 570 580 590 600
DRDVAHSQEK AIMALVDSQI GNFGRPAHVW FVSQLPKTRS GKMLRRTIQA
610 620
ICEGRDPGDL TTIDDPASLD QIRQAMEE
Length:628
Mass (Da):69,351
Last modified:February 1, 1997 - v1
Checksum:iB192E2E49ED900D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA Translation: AAB18059.1
U00096 Genomic DNA Translation: AAC73438.1
AP009048 Genomic DNA Translation: BAE76117.1
PIRiG64760
RefSeqiNP_414869.1, NC_000913.3
WP_000010288.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73438; AAC73438; b0335
BAE76117; BAE76117; BAE76117
GeneIDi946891
KEGGiecj:JW0326
eco:b0335
PATRICifig|1411691.4.peg.1942

Similar proteinsi

Entry informationi

Entry nameiPRPE_ECOLI
AccessioniPrimary (citable) accession number: P77495
Secondary accession number(s): Q2MC89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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