UniProtKB - P77475 (YQAB_ECOLI)
Protein
Fructose-1-phosphate phosphatase YqaB
Gene
yqaB
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalyzes strongly the dephosphorylation of fructose-1-phosphate (Fru1P) and slightly the dephosphorylation of 6-phosphogluconate (6P-Glu). It has low beta-phosphoglucomutase activity.2 Publications
Cofactori
Mg2+1 Publication, Mn2+1 Publication, Co2+1 Publication, Zn2+1 PublicationNote: Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc.1 Publication
Kineticsi
- KM=1 mM for Fru1P (with magnesium ions as cofactor and at pH 9)1 Publication
- KM=3.9 mM for 6P-Glu (with magnesium ions as cofactor and at pH 9)1 Publication
pH dependencei
Optimum pH is between 6 and 7.5.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 11 | NucleophileBy similarity | 1 | |
Metal bindingi | 11 | MagnesiumBy similarity | 1 | |
Metal bindingi | 13 | MagnesiumBy similarity | 1 | |
Metal bindingi | 167 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- beta-phosphoglucomutase activity Source: EcoliWiki
- magnesium ion binding Source: UniProtKB
- phosphatase activity Source: EcoliWiki
- sugar-phosphatase activity Source: EcoCyc
Keywordsi
Molecular function | Hydrolase |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:G7408-MONOMER MetaCyc:G7408-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Fructose-1-phosphate phosphatase YqaB (EC:3.1.3.-)Alternative name(s): Fructose-1-phosphatase |
Gene namesi | Name:yqaB Ordered Locus Names:b2690, JW2665 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000108063 | 1 – 188 | Fructose-1-phosphate phosphatase YqaBAdd BLAST | 188 |
Proteomic databases
jPOSTi | P77475 |
PaxDbi | P77475 |
PRIDEi | P77475 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262273, 26 interactors |
DIPi | DIP-12842N |
IntActi | P77475, 5 interactors |
STRINGi | 511145.b2690 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 11 – 13 | Substrate bindingBy similarity | 3 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0637, Bacteria |
HOGENOMi | CLU_045011_13_3_6 |
InParanoidi | P77475 |
PhylomeDBi | P77475 |
Family and domain databases
Gene3Di | 1.10.150.240, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR010976, B-phosphoglucomutase_hydrolase IPR036412, HAD-like_sf IPR006439, HAD-SF_hydro_IA IPR041492, HAD_2 IPR023214, HAD_sf IPR023198, PGP-like_dom2 |
Pfami | View protein in Pfam PF13419, HAD_2, 1 hit |
PRINTSi | PR00413, HADHALOGNASE |
SUPFAMi | SSF56784, SSF56784, 1 hit |
TIGRFAMsi | TIGR01509, HAD-SF-IA-v3, 1 hit TIGR02009, PGMB-YQAB-SF, 1 hit |
i Sequence
Sequence statusi: Complete.
P77475-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYERYAGLIF DMDGTILDTE PTHRKAWREV LGHYGLQYDI QAMIALNGSP
60 70 80 90 100
TWRIAQAIIE LNQADLDPHA LAREKTEAVR SMLLDSVEPL PLVDVVKSWH
110 120 130 140 150
GRRPMAVGTG SESAIAEALL AHLGLRHYFD AVVAADHVKH HKPAPDTFLL
160 170 180
CAQRMGVQPT QCVVFEDADF GIQAARAAGM DAVDVRLL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC75737.1 AP009048 Genomic DNA Translation: BAA16557.1 |
PIRi | C65049 |
RefSeqi | NP_417175.1, NC_000913.3 WP_000273290.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75737; AAC75737; b2690 BAA16557; BAA16557; BAA16557 |
GeneIDi | 57728652 945776 |
KEGGi | ecj:JW2665 eco:b2690 |
PATRICi | fig|1411691.4.peg.4049 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC75737.1 AP009048 Genomic DNA Translation: BAA16557.1 |
PIRi | C65049 |
RefSeqi | NP_417175.1, NC_000913.3 WP_000273290.1, NZ_LN832404.1 |
3D structure databases
SMRi | P77475 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262273, 26 interactors |
DIPi | DIP-12842N |
IntActi | P77475, 5 interactors |
STRINGi | 511145.b2690 |
Proteomic databases
jPOSTi | P77475 |
PaxDbi | P77475 |
PRIDEi | P77475 |
Protocols and materials databases
DNASUi | 945776 |
Genome annotation databases
EnsemblBacteriai | AAC75737; AAC75737; b2690 BAA16557; BAA16557; BAA16557 |
GeneIDi | 57728652 945776 |
KEGGi | ecj:JW2665 eco:b2690 |
PATRICi | fig|1411691.4.peg.4049 |
Organism-specific databases
EchoBASEi | EB3301 |
Phylogenomic databases
eggNOGi | COG0637, Bacteria |
HOGENOMi | CLU_045011_13_3_6 |
InParanoidi | P77475 |
PhylomeDBi | P77475 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7408-MONOMER MetaCyc:G7408-MONOMER |
Miscellaneous databases
PROi | PR:P77475 |
Family and domain databases
Gene3Di | 1.10.150.240, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR010976, B-phosphoglucomutase_hydrolase IPR036412, HAD-like_sf IPR006439, HAD-SF_hydro_IA IPR041492, HAD_2 IPR023214, HAD_sf IPR023198, PGP-like_dom2 |
Pfami | View protein in Pfam PF13419, HAD_2, 1 hit |
PRINTSi | PR00413, HADHALOGNASE |
SUPFAMi | SSF56784, SSF56784, 1 hit |
TIGRFAMsi | TIGR01509, HAD-SF-IA-v3, 1 hit TIGR02009, PGMB-YQAB-SF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YQAB_ECOLI | |
Accessioni | P77475Primary (citable) accession number: P77475 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | February 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families