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Protein

Probable cyclic di-GMP phosphodiesterase PdeB

Gene

pdeB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG.By similarity

Catalytic activityi

Cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine.By similarity

GO - Molecular functioni

  • cyclic-guanylate-specific phosphodiesterase activity Source: EcoCyc

Keywordsi

Molecular functionHydrolase
Ligandc-di-GMP

Enzyme and pathway databases

BioCyciEcoCyc:G6252-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cyclic di-GMP phosphodiesterase PdeBCurated (EC:3.1.4.52By similarity)
Gene namesi
Name:pdeB1 Publication
Synonyms:ylaB
Ordered Locus Names:b0457, JW5062
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14237 ylaB

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001686331 – 516Probable cyclic di-GMP phosphodiesterase PdeBAdd BLAST516

Proteomic databases

PaxDbiP77473
PRIDEiP77473

Expressioni

Inductioni

Expressed during transition into stationary phase, at both 28 and 37 degrees Celsius. Expression is RpoS dependent.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261748, 14 interactors
STRINGi316385.ECDH10B_0413

Structurei

3D structure databases

ProteinModelPortaliP77473
SMRiP77473
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 516EALPROSITE-ProRule annotationAdd BLAST249

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41066DG Bacteria
COG4943 LUCA
HOGENOMiHOG000117610
InParanoidiP77473
OMAiCLKIDKA
PhylomeDBiP77473

Family and domain databases

CDDicd01948 EAL, 1 hit
Gene3Di3.20.20.450, 1 hit
InterProiView protein in InterPro
IPR024744 CSS-motif_dom
IPR001633 EAL_dom
IPR035919 EAL_sf
PfamiView protein in Pfam
PF12792 CSS-motif, 1 hit
PF00563 EAL, 1 hit
SMARTiView protein in SMART
SM00052 EAL, 1 hit
SUPFAMiSSF141868 SSF141868, 1 hit
PROSITEiView protein in PROSITE
PS50883 EAL, 1 hit

Sequencei

Sequence statusi: Complete.

P77473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTRHLVGLI SGVLILSVLL PVGLSIWLAH QQVETSFIEE LDTYSSRVAI
60 70 80 90 100
RANKVATQGK DALQELERWQ GAACSEAHLM EMRRVSYSYR YIQEVAYIDN
110 120 130 140 150
NVPQCSSLEH ESPPDTFPEP GKISKDGYRV WLTSHNDLGI IRYMVAMGTA
160 170 180 190 200
HYVVMIDPAS FIDVIPYSSW QIDAAIIGNA HNVVITSSDE IAQGIITRLQ
210 220 230 240 250
KTPGEHIENN GIIYDILPLP EMNISIITWA STKMLQKGWH RQVFIWLPLG
260 270 280 290 300
LVIGLLAAMF VLRILRRIQS PHHRLQDAIE NRDICVHYQP IVSLANGKIV
310 320 330 340 350
GAEALARWPQ TDGSWLSPDS FIPLAQQTGL SEPLTLLIIR SVFEDMGDWL
360 370 380 390 400
RQHPQQHISI NLESPVLTSE KIPQLLRDMI NHYQVNPRQI ALELTEREFA
410 420 430 440 450
DPKTSAPIIS RYREAGHEIY LDDFGTGYSS LSYLQDLDVD ILKIDKSFVD
460 470 480 490 500
ALEYKNVTPH IIEMAKTLKL KMVAEGIETS KQEEWLRQHG VHYGQGWLYS
510
KALPKEDFLR WAEQHL
Length:516
Mass (Da):58,720
Last modified:July 11, 2001 - v2
Checksum:i3FC1355E51CF6464
GO

Sequence cautioni

The sequence AAB40212 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA Translation: AAB40212.1 Different initiation.
U00096 Genomic DNA Translation: AAC73559.2
AP009048 Genomic DNA Translation: BAE76236.1
PIRiH64775
RefSeqiNP_414990.2, NC_000913.3
WP_001310610.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73559; AAC73559; b0457
BAE76236; BAE76236; BAE76236
GeneIDi948951
KEGGiecj:JW5062
eco:b0457
PATRICifig|1411691.4.peg.1819

Similar proteinsi

Entry informationi

Entry nameiPDEB_ECOLI
AccessioniPrimary (citable) accession number: P77473
Secondary accession number(s): Q2MBX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 11, 2001
Last modified: March 28, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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