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Protein

[Citrate [pro-3S]-lyase] ligase

Gene

citC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.

Catalytic activityi

ATP + acetate + holo-[citrate (pro-3S)-lyase] = AMP + diphosphate + acetyl-[citrate (pro-3S)-lyase].

GO - Molecular functioni

  • [citrate (pro-3S)-lyase] ligase activity Source: EcoCyc
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • biosynthetic process Source: InterPro
  • cellular protein modification process Source: EcoCyc

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:CITC-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
[Citrate [pro-3S]-lyase] ligase (EC:6.2.1.22)
Alternative name(s):
Acetate:SH-citrate lyase ligase
Citrate lyase synthetase
Gene namesi
Name:citC
Synonyms:ybeO
Ordered Locus Names:b0618, JW0610
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13645 citC

Pathology & Biotechi

Chemistry databases

DrugBankiDB00336 Nitrofural

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000897701 – 352[Citrate [pro-3S]-lyase] ligaseAdd BLAST352

Proteomic databases

PaxDbiP77390
PRIDEiP77390

Expressioni

Inductioni

Repressed by H-NS. Part of the citCDEFXG operon.1 Publication

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
yaiIP0A8D32EBI-1119239,EBI-1116378

Protein-protein interaction databases

BioGridi4259904, 14 interactors
IntActiP77390, 9 interactors
STRINGi316385.ECDH10B_0686

Structurei

3D structure databases

ProteinModelPortaliP77390
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 128N-acetyltransferasePROSITE-ProRule annotationAdd BLAST128

Phylogenomic databases

eggNOGiENOG4105DUA Bacteria
COG3053 LUCA
HOGENOMiHOG000117934
InParanoidiP77390
KOiK01910
OMAiGHQYLVE
PhylomeDBiP77390

Family and domain databases

Gene3Di3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR005216 Citrate_lyase_ligase
IPR013166 Citrate_lyase_ligase_C
IPR004821 Cyt_trans-like
IPR000182 GNAT_dom
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR40599 PTHR40599, 1 hit
PfamiView protein in Pfam
PF08218 Citrate_ly_lig, 1 hit
PIRSFiPIRSF005751 Acet_citr_lig, 1 hit
SMARTiView protein in SMART
SM00764 Citrate_ly_lig, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
TIGRFAMsiTIGR00124 cit_ly_ligase, 1 hit
TIGR00125 cyt_tran_rel, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

P77390-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGNDIFTRV KRSENKKMAE IAQFLHENDL SVDTTVEVFI TVTRDEKLIA
60 70 80 90 100
CGGIAGNIIK CVAISESVRG EGLALTLATE LINLAYERHS THLFIYTKTE
110 120 130 140 150
YEALFRQCGF STLTSVPGVM VLMENSATRL KRYAESLKKF RHPGNKIGCI
160 170 180 190 200
VMNANPFTNG HRYLIQQAAA QCDWLHLFLV KEDSSRFPYE DRLDLVLKGT
210 220 230 240 250
ADIPRLTVHR GSEYIISRAT FPCYFIKEQS VINHCYTEID LKIFRQYLAP
260 270 280 290 300
ALGVTHRFVG TEPFCRVTAQ YNQDMRYWLE TPTISAPPIE LVEIERLRYQ
310 320 330 340 350
EMPISASRVR QLLAKNDLTA IAPLVPAVTL HYLQNLLEHS RQDAAARQKT

PA
Length:352
Mass (Da):40,077
Last modified:November 1, 1997 - v2
Checksum:iF5894FFCD0F06518
GO

Sequence cautioni

The sequence AAB40818 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA Translation: AAB40818.1 Different initiation.
U00096 Genomic DNA Translation: AAC73719.2
AP009048 Genomic DNA Translation: BAA35254.2
U46667 Genomic DNA Translation: AAC28950.1
PIRiH64795
RefSeqiNP_415151.4, NC_000913.3
WP_000467705.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73719; AAC73719; b0618
BAA35254; BAA35254; BAA35254
GeneIDi945231
KEGGiecj:JW0610
eco:b0618
PATRICifig|1411691.4.peg.1650

Similar proteinsi

Entry informationi

Entry nameiCITC_ECOLI
AccessioniPrimary (citable) accession number: P77390
Secondary accession number(s): O54337, Q9R2T4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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