UniProtKB - P77377 (WZXC_ECOLI)
Protein
Lipopolysaccharide biosynthesis protein WzxC
Gene
wzxC
Organism
Escherichia coli (strain K12)
Status
Functioni
: lipopolysaccharide biosynthesis Pathwayi
This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.
GO - Biological processi
- colanic acid biosynthetic process Source: EcoCyc
- lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Biological process | Lipopolysaccharide biosynthesis |
Enzyme and pathway databases
BioCyci | EcoCyc:G7097-MONOMER MetaCyc:G7097-MONOMER |
UniPathwayi | UPA00030 |
Protein family/group databases
TCDBi | 2.A.66.2.7, the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Lipopolysaccharide biosynthesis protein WzxC |
Gene namesi | Name:wzxC Synonyms:wzx Ordered Locus Names:b2046, JW2031 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 12 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 13 – 33 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 34 – 42 | PeriplasmicSequence analysis | 9 | |
Transmembranei | 43 – 63 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 64 – 81 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 82 – 102 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 103 – 104 | PeriplasmicSequence analysis | 2 | |
Transmembranei | 105 – 125 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 126 – 157 | CytoplasmicSequence analysisAdd BLAST | 32 | |
Transmembranei | 158 – 178 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 179 – 236 | PeriplasmicSequence analysisAdd BLAST | 58 | |
Transmembranei | 237 – 257 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 258 – 288 | CytoplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 289 – 309 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 310 – 322 | PeriplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 323 – 343 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 344 – 364 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 365 – 385 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 386 | PeriplasmicSequence analysis | 1 | |
Transmembranei | 387 – 407 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 408 – 417 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 418 – 438 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 439 – 445 | PeriplasmicSequence analysis | 7 | |
Transmembranei | 446 – 466 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 467 – 492 | CytoplasmicSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000166453 | 1 – 492 | Lipopolysaccharide biosynthesis protein WzxCAdd BLAST | 492 |
Proteomic databases
PaxDbi | P77377 |
PRIDEi | P77377 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4263313, 412 interactors |
DIPi | DIP-11136N |
IntActi | P77377, 1 interactor |
STRINGi | 511145.b2046 |
Family & Domainsi
Sequence similaritiesi
Belongs to the polysaccharide synthase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2244, Bacteria |
HOGENOMi | CLU_026911_2_1_6 |
InParanoidi | P77377 |
PhylomeDBi | P77377 |
i Sequence
Sequence statusi: Complete.
P77377-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLREKTISG AKWSAIATVI IIGLGLVQMT VLARIIDNHQ FGLLTVSLVI
60 70 80 90 100
IALADTLSDF GIANSIIQRK EISHLELTTL YWLNVGLGIV VCVAVFLLSD
110 120 130 140 150
LIGDVLNNPD LAPLIKTLSL AFVVIPHGQQ FRALMQKELE FNKIGMIETS
160 170 180 190 200
AVLAGFTCTV VSAHFWPLAM TAILGYLVNS AVRTLLFGYF GRKIYRPGLH
210 220 230 240 250
FSLASVAPNL RFGAWLTADS IINYLNTNLS TLVLARILGA GVAGGYNLAY
260 270 280 290 300
NVAVVPPMKL NPIITRVLFP AFAKIQDDTE KLRVNFYKLL SVVGIINFPA
310 320 330 340 350
LLGLMVVSNN FVPLVFGEKW NSIIPVLQLL CVVGLLRSVG NPIGSLLMAK
360 370 380 390 400
ARVDISFKFN VFKTFLFIPA IVIGGQMAGA IGVTLGFLLV QIINTILSYF
410 420 430 440 450
VMIKPVLGSS YRQYILSLWL PFYLSLPTLV VSYALGIVLK GQLALGMLLA
460 470 480 490
VQIATGVLAF VVMIVLSRHP LVVEVKRQFC RSEKMKMLLR AG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U38473 Genomic DNA Translation: AAC77849.1 U00096 Genomic DNA Translation: AAC75107.1 AP009048 Genomic DNA Translation: BAA15899.1 |
PIRi | E64970 |
RefSeqi | NP_416550.1, NC_000913.3 WP_000058424.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75107; AAC75107; b2046 BAA15899; BAA15899; BAA15899 |
GeneIDi | 946581 |
KEGGi | ecj:JW2031 eco:b2046 |
PATRICi | fig|1411691.4.peg.205 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U38473 Genomic DNA Translation: AAC77849.1 U00096 Genomic DNA Translation: AAC75107.1 AP009048 Genomic DNA Translation: BAA15899.1 |
PIRi | E64970 |
RefSeqi | NP_416550.1, NC_000913.3 WP_000058424.1, NZ_LN832404.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4263313, 412 interactors |
DIPi | DIP-11136N |
IntActi | P77377, 1 interactor |
STRINGi | 511145.b2046 |
Protein family/group databases
TCDBi | 2.A.66.2.7, the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily |
Proteomic databases
PaxDbi | P77377 |
PRIDEi | P77377 |
Genome annotation databases
EnsemblBacteriai | AAC75107; AAC75107; b2046 BAA15899; BAA15899; BAA15899 |
GeneIDi | 946581 |
KEGGi | ecj:JW2031 eco:b2046 |
PATRICi | fig|1411691.4.peg.205 |
Organism-specific databases
EchoBASEi | EB3346 |
Phylogenomic databases
eggNOGi | COG2244, Bacteria |
HOGENOMi | CLU_026911_2_1_6 |
InParanoidi | P77377 |
PhylomeDBi | P77377 |
Enzyme and pathway databases
UniPathwayi | UPA00030 |
BioCyci | EcoCyc:G7097-MONOMER MetaCyc:G7097-MONOMER |
Miscellaneous databases
PROi | PR:P77377 |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | WZXC_ECOLI | |
Accessioni | P77377Primary (citable) accession number: P77377 Secondary accession number(s): O08001, O08002 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | February 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families