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UniProtKB - P77377 (WZXC_ECOLI)

Entry version 139 (02 Dec 2020)
Sequence version 1 (01 Feb 1997)
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Protein

Lipopolysaccharide biosynthesis protein WzxC

Gene

wzxC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:G7097-MONOMER
MetaCyc:G7097-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00030

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.66.2.7, the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lipopolysaccharide biosynthesis protein WzxC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:wzxC
Synonyms:wzx
Ordered Locus Names:b2046, JW2031
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 42PeriplasmicSequence analysis9
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Topological domaini64 – 81CytoplasmicSequence analysisAdd BLAST18
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 104PeriplasmicSequence analysis2
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 157CytoplasmicSequence analysisAdd BLAST32
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 236PeriplasmicSequence analysisAdd BLAST58
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Topological domaini258 – 288CytoplasmicSequence analysisAdd BLAST31
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 322PeriplasmicSequence analysisAdd BLAST13
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 364CytoplasmicSequence analysisAdd BLAST21
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Topological domaini386PeriplasmicSequence analysis1
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21
Topological domaini408 – 417CytoplasmicSequence analysis10
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Topological domaini439 – 445PeriplasmicSequence analysis7
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21
Topological domaini467 – 492CytoplasmicSequence analysisAdd BLAST26

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001664531 – 492Lipopolysaccharide biosynthesis protein WzxCAdd BLAST492

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P77377

PRoteomics IDEntifications database

More...PRIDEi		P77377

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4263313, 412 interactors

Database of interacting proteins

More...DIPi		DIP-11136N

Protein interaction database and analysis system

More...IntActi		P77377, 1 interactor

STRING: functional protein association networks

More...STRINGi		511145.b2046

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polysaccharide synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG2244, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_026911_2_1_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P77377

Database for complete collections of gene phylogenies

More...PhylomeDBi		P77377

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P77377-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLREKTISG AKWSAIATVI IIGLGLVQMT VLARIIDNHQ FGLLTVSLVI 
        60         70         80         90        100
IALADTLSDF GIANSIIQRK EISHLELTTL YWLNVGLGIV VCVAVFLLSD 
       110        120        130        140        150
LIGDVLNNPD LAPLIKTLSL AFVVIPHGQQ FRALMQKELE FNKIGMIETS 
       160        170        180        190        200
AVLAGFTCTV VSAHFWPLAM TAILGYLVNS AVRTLLFGYF GRKIYRPGLH 
       210        220        230        240        250
FSLASVAPNL RFGAWLTADS IINYLNTNLS TLVLARILGA GVAGGYNLAY 
       260        270        280        290        300
NVAVVPPMKL NPIITRVLFP AFAKIQDDTE KLRVNFYKLL SVVGIINFPA 
       310        320        330        340        350
LLGLMVVSNN FVPLVFGEKW NSIIPVLQLL CVVGLLRSVG NPIGSLLMAK 
       360        370        380        390        400
ARVDISFKFN VFKTFLFIPA IVIGGQMAGA IGVTLGFLLV QIINTILSYF 
       410        420        430        440        450
VMIKPVLGSS YRQYILSLWL PFYLSLPTLV VSYALGIVLK GQLALGMLLA 
       460        470        480        490 
VQIATGVLAF VVMIVLSRHP LVVEVKRQFC RSEKMKMLLR AG
Length:492
Mass (Da):53,693
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i893E505759363A80
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U38473 Genomic DNA Translation: AAC77849.1
U00096 Genomic DNA Translation: AAC75107.1
AP009048 Genomic DNA Translation: BAA15899.1

Protein sequence database of the Protein Information Resource

More...PIRi		E64970

NCBI Reference Sequences

More...RefSeqi		NP_416550.1, NC_000913.3
WP_000058424.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC75107; AAC75107; b2046
BAA15899; BAA15899; BAA15899

Database of genes from NCBI RefSeq genomes

More...GeneIDi		946581

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW2031
eco:b2046

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.205

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38473 Genomic DNA Translation: AAC77849.1
U00096 Genomic DNA Translation: AAC75107.1
AP009048 Genomic DNA Translation: BAA15899.1
PIRiE64970
RefSeqiNP_416550.1, NC_000913.3
WP_000058424.1, NZ_LN832404.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4263313, 412 interactors
DIPiDIP-11136N
IntActiP77377, 1 interactor
STRINGi511145.b2046

Protein family/group databases

TCDBi2.A.66.2.7, the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily

Proteomic databases

PaxDbiP77377
PRIDEiP77377

Genome annotation databases

EnsemblBacteriaiAAC75107; AAC75107; b2046
BAA15899; BAA15899; BAA15899
GeneIDi946581
KEGGiecj:JW2031
eco:b2046
PATRICifig|1411691.4.peg.205

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB3346

Phylogenomic databases

eggNOGiCOG2244, Bacteria
HOGENOMiCLU_026911_2_1_6
InParanoidiP77377
PhylomeDBiP77377

Enzyme and pathway databases

UniPathwayiUPA00030
BioCyciEcoCyc:G7097-MONOMER
MetaCyc:G7097-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P77377

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWZXC_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P77377
Secondary accession number(s): O08001, O08002
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: December 2, 2020
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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