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Protein

p-aminobenzoyl-glutamate hydrolase subunit A

Gene

abgA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the p-aminobenzoyl-glutamate hydrolase multicomponent enzyme system which catalyzes the cleavage of p-aminobenzoyl-glutamate (PABA-GLU) to form p-aminobenzoate (PABA) and glutamate. AbgAB does not degrade dipeptides and the physiological role of abgABT should be clarified.2 Publications

Cofactori

Mn2+1 Publication

Kineticsi

  1. KM=60 µM for PABA-GLU (at pH 8.5)1 Publication

    GO - Molecular functioni

    • para-aminobenzoyl-glutamate hydrolase activity Source: UniProtKB
    • protein heterodimerization activity Source: EcoliWiki

    GO - Biological processi

    • folic acid catabolic process Source: EcoliWiki

    Keywordsi

    Molecular functionHydrolase

    Enzyme and pathway databases

    BioCyciEcoCyc:G6670-MONOMER
    MetaCyc:G6670-MONOMER

    Protein family/group databases

    MEROPSiM20.020

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    p-aminobenzoyl-glutamate hydrolase subunit A (EC:3.5.1.-)
    Alternative name(s):
    PABA-GLU hydrolase
    Short name:
    PGH
    Gene namesi
    Name:abgA
    Synonyms:ydaJ
    Ordered Locus Names:b1338, JW5205
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    Proteomesi
    • UP000000318 Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    Organism-specific databases

    EcoGeneiEG13352 abgA

    Subcellular locationi

    GO - Cellular componenti

    • cytoplasm Source: EcoliWiki

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000619581 – 436p-aminobenzoyl-glutamate hydrolase subunit AAdd BLAST436

    Proteomic databases

    EPDiP77357
    PaxDbiP77357
    PRIDEiP77357

    Expressioni

    Inductioni

    Could be transcriptionally regulated by AbgR.1 Publication

    Interactioni

    Subunit structurei

    Forms a heterodimer with AbgB.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    abgBP760522EBI-9155452,EBI-1123629

    GO - Molecular functioni

    • protein heterodimerization activity Source: EcoliWiki

    Protein-protein interaction databases

    BioGridi4261854, 23 interactors
    ComplexPortaliCPX-28 p-aminobenzoyl-glutamate hydrolase
    IntActiP77357, 2 interactors
    STRINGi316385.ECDH10B_1458

    Structurei

    3D structure databases

    ProteinModelPortaliP77357
    SMRiP77357
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M20 family.Curated

    Phylogenomic databases

    eggNOGiENOG4105CH2 Bacteria
    COG1473 LUCA
    HOGENOMiHOG000241405
    InParanoidiP77357
    KOiK12940
    OMAiMTHSVIP
    PhylomeDBiP77357

    Family and domain databases

    CDDicd05665 M20_Acy1_IAAspH_bact, 1 hit
    InterProiView protein in InterPro
    IPR033845 AbgA
    IPR017439 Amidohydrolase
    IPR036264 Bact_exopeptidase_dim_dom
    IPR002933 Peptidase_M20
    IPR011650 Peptidase_M20_dimer
    PfamiView protein in Pfam
    PF07687 M20_dimer, 1 hit
    PF01546 Peptidase_M20, 1 hit
    PIRSFiPIRSF005962 Pept_M20D_amidohydro, 1 hit
    SUPFAMiSSF55031 SSF55031, 1 hit
    TIGRFAMsiTIGR01891 amidohydrolases, 1 hit

    Sequencei

    Sequence statusi: Complete.

    P77357-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MESLNQFVNS LAPKLSHWRR DFHHYAESGW VEFRTATLVA EELHQLGYSL
    60 70 80 90 100
    ALGREVVNES SRMGLPDEFT LQREFERARQ QGALAQWIAA FEGGFTGIVA
    110 120 130 140 150
    TLDTGRPGPV MAFRVDMDAL DLSEEQDVSH RPYRDGFASC NAGMMHACGH
    160 170 180 190 200
    DGHTAIGLGL AHTLKQFESG LHGVIKLIFQ PAEEGTRGAR AMVDAGVVDD
    210 220 230 240 250
    VDYFTAVHIG TGVPAGTVVC GSDNFMATTK FDAHFTGTAA HAGAKPEDGH
    260 270 280 290 300
    NALLAAAQAT LALHAIAPHS EGASRVNVGV MQAGSGRNVV PASALLKVET
    310 320 330 340 350
    RGASDVINQY VFDRAQQAIQ GAATMYGVGV ETRLMGAATA SSPSPQWVAW
    360 370 380 390 400
    LQSQAAQVAG VNQAIERVEA PAGSEDATLM MARVQQHQGQ ASYVVFGTQL
    410 420 430
    AAGHHNEKFD FDEQVLAIAV ETLARTALNF PWTRGI
    Length:436
    Mass (Da):46,588
    Last modified:January 11, 2001 - v2
    Checksum:iCAA22D6925D61F56
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U00096 Genomic DNA Translation: AAC74420.2
    AP009048 Genomic DNA Translation: BAA14940.2
    PIRiE64883
    RefSeqiNP_415854.4, NC_000913.3
    WP_000444929.1, NZ_LN832404.1

    Genome annotation databases

    EnsemblBacteriaiAAC74420; AAC74420; b1338
    BAA14940; BAA14940; BAA14940
    GeneIDi945742
    KEGGiecj:JW5205
    eco:b1338
    PATRICifig|1411691.4.peg.939

    Similar proteinsi

    Entry informationi

    Entry nameiABGA_ECOLI
    AccessioniPrimary (citable) accession number: P77357
    Secondary accession number(s): P76847
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 11, 2001
    Last modified: June 20, 2018
    This is version 125 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

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