UniProtKB - P77348 (MPPA_ECOLI)
Protein
Periplasmic murein peptide-binding protein
Gene
mppA
Organism
Escherichia coli (strain K12)
Status
Functioni
Essential for the uptake of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate. Also transports some alpha-linked peptides such as Pro-Phe-Lys with low affinity. The transport is effected by the oligopeptide permease system.
GO - Molecular functioni
- oligopeptide binding Source: EcoCyc
- peptide transmembrane transporter activity Source: GO_Central
GO - Biological processi
- peptide transport Source: GO_Central
- protein transport Source: UniProtKB-KW
- tripeptide transport Source: EcoliWiki
Keywordsi
Biological process | Peptide transport, Protein transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:G6665-MONOMER MetaCyc:G6665-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.5.1, the atp-binding cassette (abc) superfamily 3.A.1.5.41, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Periplasmic murein peptide-binding protein |
Gene namesi | Name:mppA Synonyms:ynaH Ordered Locus Names:b1329, JW1322 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Other locations
Plasma Membrane
- ATP-binding cassette (ABC) transporter complex Source: InterPro
Other locations
- outer membrane-bounded periplasmic space Source: EcoCyc
- periplasmic space Source: EcoliWiki
Keywords - Cellular componenti
PeriplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | 1 PublicationAdd BLAST | 22 | |
ChainiPRO_0000031792 | 23 – 537 | Periplasmic murein peptide-binding proteinAdd BLAST | 515 |
Proteomic databases
jPOSTi | P77348 |
PaxDbi | P77348 |
PRIDEi | P77348 |
2D gel databases
SWISS-2DPAGEi | P77348 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260155, 288 interactors |
ComplexPortali | CPX-4343, Murein tripeptide ABC transporter complex CPX-4346, Heme/dipeptide ABC transporter complex, mppA variant |
STRINGi | 511145.b1329 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P77348 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P77348 |
Family & Domainsi
Sequence similaritiesi
Belongs to the bacterial solute-binding protein 5 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | COG4166, Bacteria |
HOGENOMi | CLU_017028_0_3_6 |
InParanoidi | P77348 |
PhylomeDBi | P77348 |
Family and domain databases
InterProi | View protein in InterPro IPR030678, Peptide/Ni-bd IPR039424, SBP_5 IPR023765, SBP_5_CS IPR000914, SBP_5_dom |
PANTHERi | PTHR30290, PTHR30290, 1 hit |
Pfami | View protein in Pfam PF00496, SBP_bac_5, 1 hit |
PIRSFi | PIRSF002741, MppA, 1 hit |
PROSITEi | View protein in PROSITE PS01040, SBP_BACTERIAL_5, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P77348-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKHSVSVTCC ALLVSSISLS YAAEVPSGTV LAEKQELVRH IKDEPASLDP
60 70 80 90 100
AKAVGLPEIQ VIRDLFEGLV NQNEKGEIVP GVATQWKSND NRIWTFTLRD
110 120 130 140 150
NAKWADGTPV TAQDFVYSWQ RLVDPKTLSP FAWFAALAGI NNAQAIIDGK
160 170 180 190 200
ATPDQLGVTA VDAHTLKIQL DKPLPWFVNL TANFAFFPVQ KANVESGKEW
210 220 230 240 250
TKPGNLIGNG AYVLKERVVN EKLVVVPNTH YWDNAKTVLQ KVTFLPINQE
260 270 280 290 300
SAATKRYLAG DIDITESFPK NMYQKLLKDI PGQVYTPPQL GTYYYAFNTQ
310 320 330 340 350
KGPTADQRVR LALSMTIDRR LMTEKVLGTG EKPAWHFTPD VTAGFTPEPS
360 370 380 390 400
PFEQMSQEEL NAQAKTLLSA AGYGPQKPLK LTLLYNTSEN HQKIAIAVAS
410 420 430 440 450
MWKKNLGVDV KLQNQEWKTY IDSRNTGNFD VIRASWVGDY NEPSTFLTLL
460 470 480 490 500
TSTHSGNISR FNNPAYDKVL AQASTENTVK ARNADYNAAE KILMEQAPIA
510 520 530
PIYQYTNGRL IKPWLKGYPI NNPEDVAYSR TMYIVKH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U88242 Genomic DNA Translation: AAC38216.1 U00096 Genomic DNA Translation: AAC74411.2 AP009048 Genomic DNA Translation: BAA14922.2 |
PIRi | D64882 |
RefSeqi | NP_415845.2, NC_000913.3 WP_000683020.1, NZ_STEB01000005.1 |
Genome annotation databases
EnsemblBacteriai | AAC74411; AAC74411; b1329 BAA14922; BAA14922; BAA14922 |
GeneIDi | 945951 |
KEGGi | ecj:JW1322 eco:b1329 |
PATRICi | fig|1411691.4.peg.948 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U88242 Genomic DNA Translation: AAC38216.1 U00096 Genomic DNA Translation: AAC74411.2 AP009048 Genomic DNA Translation: BAA14922.2 |
PIRi | D64882 |
RefSeqi | NP_415845.2, NC_000913.3 WP_000683020.1, NZ_STEB01000005.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3O9P | X-ray | 2.07 | A | 23-537 | [»] | |
4TOZ | X-ray | 1.50 | A/B | 23-537 | [»] | |
SMRi | P77348 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4260155, 288 interactors |
ComplexPortali | CPX-4343, Murein tripeptide ABC transporter complex CPX-4346, Heme/dipeptide ABC transporter complex, mppA variant |
STRINGi | 511145.b1329 |
Protein family/group databases
TCDBi | 3.A.1.5.1, the atp-binding cassette (abc) superfamily 3.A.1.5.41, the atp-binding cassette (abc) superfamily |
2D gel databases
SWISS-2DPAGEi | P77348 |
Proteomic databases
jPOSTi | P77348 |
PaxDbi | P77348 |
PRIDEi | P77348 |
Genome annotation databases
EnsemblBacteriai | AAC74411; AAC74411; b1329 BAA14922; BAA14922; BAA14922 |
GeneIDi | 945951 |
KEGGi | ecj:JW1322 eco:b1329 |
PATRICi | fig|1411691.4.peg.948 |
Organism-specific databases
EchoBASEi | EB3158 |
Phylogenomic databases
eggNOGi | COG4166, Bacteria |
HOGENOMi | CLU_017028_0_3_6 |
InParanoidi | P77348 |
PhylomeDBi | P77348 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6665-MONOMER MetaCyc:G6665-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P77348 |
PROi | PR:P77348 |
Family and domain databases
InterProi | View protein in InterPro IPR030678, Peptide/Ni-bd IPR039424, SBP_5 IPR023765, SBP_5_CS IPR000914, SBP_5_dom |
PANTHERi | PTHR30290, PTHR30290, 1 hit |
Pfami | View protein in Pfam PF00496, SBP_bac_5, 1 hit |
PIRSFi | PIRSF002741, MppA, 1 hit |
PROSITEi | View protein in PROSITE PS01040, SBP_BACTERIAL_5, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MPPA_ECOLI | |
Accessioni | P77348Primary (citable) accession number: P77348 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | December 15, 1998 | |
Last modified: | April 7, 2021 | |
This is version 142 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families