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Entry version 136 (11 Dec 2019)
Sequence version 2 (15 Dec 1998)
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Protein

Periplasmic murein peptide-binding protein

Gene

mppA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for the uptake of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate. Also transports some alpha-linked peptides such as Pro-Phe-Lys with low affinity. The transport is effected by the oligopeptide permease system.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • protein transport Source: UniProtKB-KW
  • tripeptide transport Source: EcoliWiki

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPeptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:G6665-MONOMER
ECOL316407:JW1322-MONOMER
MetaCyc:G6665-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.5.1 the atp-binding cassette (abc) superfamily
3.A.1.5.41 the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Periplasmic murein peptide-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mppA
Synonyms:ynaH
Ordered Locus Names:b1329, JW1322
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 221 PublicationAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003179223 – 537Periplasmic murein peptide-binding proteinAdd BLAST515

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P77348

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P77348

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P77348

PRoteomics IDEntifications database

More...
PRIDEi
P77348

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P77348

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4260155, 288 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-4343 Murein tripeptide ABC transporter complex
CPX-4346 Heme/dipeptide ABC transporter complex, mppA variant

STRING: functional protein association networks

More...
STRINGi
511145.b1329

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1537
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P77348

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P77348

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4107QSI Bacteria
COG4166 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000179191

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P77348

KEGG Orthology (KO)

More...
KOi
K15580

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P77348

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030678 Peptide/Ni-bd
IPR039424 SBP_5
IPR023765 SBP_5_CS
IPR000914 SBP_5_dom

The PANTHER Classification System

More...
PANTHERi
PTHR30290 PTHR30290, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00496 SBP_bac_5, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002741 MppA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01040 SBP_BACTERIAL_5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P77348-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKHSVSVTCC ALLVSSISLS YAAEVPSGTV LAEKQELVRH IKDEPASLDP
60 70 80 90 100
AKAVGLPEIQ VIRDLFEGLV NQNEKGEIVP GVATQWKSND NRIWTFTLRD
110 120 130 140 150
NAKWADGTPV TAQDFVYSWQ RLVDPKTLSP FAWFAALAGI NNAQAIIDGK
160 170 180 190 200
ATPDQLGVTA VDAHTLKIQL DKPLPWFVNL TANFAFFPVQ KANVESGKEW
210 220 230 240 250
TKPGNLIGNG AYVLKERVVN EKLVVVPNTH YWDNAKTVLQ KVTFLPINQE
260 270 280 290 300
SAATKRYLAG DIDITESFPK NMYQKLLKDI PGQVYTPPQL GTYYYAFNTQ
310 320 330 340 350
KGPTADQRVR LALSMTIDRR LMTEKVLGTG EKPAWHFTPD VTAGFTPEPS
360 370 380 390 400
PFEQMSQEEL NAQAKTLLSA AGYGPQKPLK LTLLYNTSEN HQKIAIAVAS
410 420 430 440 450
MWKKNLGVDV KLQNQEWKTY IDSRNTGNFD VIRASWVGDY NEPSTFLTLL
460 470 480 490 500
TSTHSGNISR FNNPAYDKVL AQASTENTVK ARNADYNAAE KILMEQAPIA
510 520 530
PIYQYTNGRL IKPWLKGYPI NNPEDVAYSR TMYIVKH
Length:537
Mass (Da):59,900
Last modified:December 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6A17656836DC3AC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U88242 Genomic DNA Translation: AAC38216.1
U00096 Genomic DNA Translation: AAC74411.2
AP009048 Genomic DNA Translation: BAA14922.2

Protein sequence database of the Protein Information Resource

More...
PIRi
D64882

NCBI Reference Sequences

More...
RefSeqi
NP_415845.2, NC_000913.3
WP_000683020.1, NZ_STEB01000005.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC74411; AAC74411; b1329
BAA14922; BAA14922; BAA14922

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
945951

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW1322
eco:b1329

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.948

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88242 Genomic DNA Translation: AAC38216.1
U00096 Genomic DNA Translation: AAC74411.2
AP009048 Genomic DNA Translation: BAA14922.2
PIRiD64882
RefSeqiNP_415845.2, NC_000913.3
WP_000683020.1, NZ_STEB01000005.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3O9PX-ray2.07A23-537[»]
4TOZX-ray1.50A/B23-537[»]
SMRiP77348
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi4260155, 288 interactors
ComplexPortaliCPX-4343 Murein tripeptide ABC transporter complex
CPX-4346 Heme/dipeptide ABC transporter complex, mppA variant
STRINGi511145.b1329

Protein family/group databases

TCDBi3.A.1.5.1 the atp-binding cassette (abc) superfamily
3.A.1.5.41 the atp-binding cassette (abc) superfamily

2D gel databases

SWISS-2DPAGEiP77348

Proteomic databases

EPDiP77348
jPOSTiP77348
PaxDbiP77348
PRIDEiP77348

Genome annotation databases

EnsemblBacteriaiAAC74411; AAC74411; b1329
BAA14922; BAA14922; BAA14922
GeneIDi945951
KEGGiecj:JW1322
eco:b1329
PATRICifig|1411691.4.peg.948

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB3158

Phylogenomic databases

eggNOGiENOG4107QSI Bacteria
COG4166 LUCA
HOGENOMiHOG000179191
InParanoidiP77348
KOiK15580
PhylomeDBiP77348

Enzyme and pathway databases

BioCyciEcoCyc:G6665-MONOMER
ECOL316407:JW1322-MONOMER
MetaCyc:G6665-MONOMER

Miscellaneous databases

EvolutionaryTraceiP77348

Protein Ontology

More...
PROi
PR:P77348

Family and domain databases

InterProiView protein in InterPro
IPR030678 Peptide/Ni-bd
IPR039424 SBP_5
IPR023765 SBP_5_CS
IPR000914 SBP_5_dom
PANTHERiPTHR30290 PTHR30290, 1 hit
PfamiView protein in Pfam
PF00496 SBP_bac_5, 1 hit
PIRSFiPIRSF002741 MppA, 1 hit
PROSITEiView protein in PROSITE
PS01040 SBP_BACTERIAL_5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMPPA_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P77348
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: December 11, 2019
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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