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Protein

Periplasmic murein peptide-binding protein

Gene

mppA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the uptake of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate. Also transports some alpha-linked peptides such as Pro-Phe-Lys with low affinity. The transport is effected by the oligopeptide permease system.

GO - Biological processi

  • protein transport Source: UniProtKB-KW
  • transmembrane transport Source: InterPro
  • tripeptide transport Source: EcoliWiki

Keywordsi

Biological processPeptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G6665-MONOMER
MetaCyc:G6665-MONOMER

Protein family/group databases

TCDBi3.A.1.5.1 the atp-binding cassette (abc) superfamily
3.A.1.5.41 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Periplasmic murein peptide-binding protein
Gene namesi
Name:mppA
Synonyms:ynaH
Ordered Locus Names:b1329, JW1322
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13376 mppA

Subcellular locationi

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: InterPro
  • outer membrane-bounded periplasmic space Source: EcoCyc
  • periplasmic space Source: EcoliWiki

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000003179223 – 537Periplasmic murein peptide-binding proteinAdd BLAST515

Proteomic databases

EPDiP77348
PaxDbiP77348
PRIDEiP77348

2D gel databases

SWISS-2DPAGEiP77348

Interactioni

Protein-protein interaction databases

BioGridi4260155, 288 interactors
STRINGi316385.ECDH10B_1449

Structurei

Secondary structure

1537
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi36 – 43Combined sources8
Turni50 – 52Combined sources3
Helixi56 – 65Combined sources10
Beta strandi69 – 72Combined sources4
Beta strandi78 – 87Combined sources10
Beta strandi89 – 98Combined sources10
Helixi112 – 123Combined sources12
Helixi125 – 127Combined sources3
Turni130 – 132Combined sources3
Helixi133 – 137Combined sources5
Helixi143 – 147Combined sources5
Helixi153 – 155Combined sources3
Beta strandi156 – 162Combined sources7
Beta strandi165 – 172Combined sources8
Helixi177 – 180Combined sources4
Helixi184 – 186Combined sources3
Helixi191 – 194Combined sources4
Helixi198 – 201Combined sources4
Turni203 – 205Combined sources3
Beta strandi210 – 218Combined sources9
Turni219 – 221Combined sources3
Beta strandi222 – 227Combined sources6
Helixi234 – 236Combined sources3
Beta strandi240 – 246Combined sources7
Helixi252 – 258Combined sources7
Helixi270 – 279Combined sources10
Helixi281 – 283Combined sources3
Beta strandi288 – 297Combined sources10
Beta strandi299 – 302Combined sources4
Helixi303 – 305Combined sources3
Helixi307 – 315Combined sources9
Helixi319 – 324Combined sources6
Turni325 – 327Combined sources3
Beta strandi335 – 338Combined sources4
Turni351 – 354Combined sources4
Helixi357 – 370Combined sources14
Beta strandi374 – 377Combined sources4
Beta strandi381 – 387Combined sources7
Helixi389 – 406Combined sources18
Beta strandi410 – 415Combined sources6
Helixi417 – 426Combined sources10
Beta strandi430 – 437Combined sources8
Beta strandi439 – 442Combined sources4
Helixi444 – 447Combined sources4
Helixi448 – 450Combined sources3
Helixi464 – 473Combined sources10
Helixi479 – 496Combined sources18
Beta strandi498 – 506Combined sources9
Beta strandi509 – 511Combined sources3
Helixi529 – 531Combined sources3
Beta strandi533 – 535Combined sources3

3D structure databases

ProteinModelPortaliP77348
SMRiP77348
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77348

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4107QSI Bacteria
COG4166 LUCA
HOGENOMiHOG000179191
InParanoidiP77348
KOiK15580
OMAiTSPFAWF
PhylomeDBiP77348

Family and domain databases

InterProiView protein in InterPro
IPR030678 Peptide/Ni-bd
IPR023765 SBP_5_CS
IPR000914 SBP_5_dom
PfamiView protein in Pfam
PF00496 SBP_bac_5, 1 hit
PIRSFiPIRSF002741 MppA, 1 hit
PROSITEiView protein in PROSITE
PS01040 SBP_BACTERIAL_5, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P77348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHSVSVTCC ALLVSSISLS YAAEVPSGTV LAEKQELVRH IKDEPASLDP
60 70 80 90 100
AKAVGLPEIQ VIRDLFEGLV NQNEKGEIVP GVATQWKSND NRIWTFTLRD
110 120 130 140 150
NAKWADGTPV TAQDFVYSWQ RLVDPKTLSP FAWFAALAGI NNAQAIIDGK
160 170 180 190 200
ATPDQLGVTA VDAHTLKIQL DKPLPWFVNL TANFAFFPVQ KANVESGKEW
210 220 230 240 250
TKPGNLIGNG AYVLKERVVN EKLVVVPNTH YWDNAKTVLQ KVTFLPINQE
260 270 280 290 300
SAATKRYLAG DIDITESFPK NMYQKLLKDI PGQVYTPPQL GTYYYAFNTQ
310 320 330 340 350
KGPTADQRVR LALSMTIDRR LMTEKVLGTG EKPAWHFTPD VTAGFTPEPS
360 370 380 390 400
PFEQMSQEEL NAQAKTLLSA AGYGPQKPLK LTLLYNTSEN HQKIAIAVAS
410 420 430 440 450
MWKKNLGVDV KLQNQEWKTY IDSRNTGNFD VIRASWVGDY NEPSTFLTLL
460 470 480 490 500
TSTHSGNISR FNNPAYDKVL AQASTENTVK ARNADYNAAE KILMEQAPIA
510 520 530
PIYQYTNGRL IKPWLKGYPI NNPEDVAYSR TMYIVKH
Length:537
Mass (Da):59,900
Last modified:December 15, 1998 - v2
Checksum:iC6A17656836DC3AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88242 Genomic DNA Translation: AAC38216.1
U00096 Genomic DNA Translation: AAC74411.2
AP009048 Genomic DNA Translation: BAA14922.2
PIRiD64882
RefSeqiNP_415845.2, NC_000913.3
WP_000683020.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74411; AAC74411; b1329
BAA14922; BAA14922; BAA14922
GeneIDi945951
KEGGiecj:JW1322
eco:b1329
PATRICifig|1411691.4.peg.948

Similar proteinsi

Entry informationi

Entry nameiMPPA_ECOLI
AccessioniPrimary (citable) accession number: P77348
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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