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Protein

Periplasmic murein peptide-binding protein

Gene

mppA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the uptake of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate. Also transports some alpha-linked peptides such as Pro-Phe-Lys with low affinity. The transport is effected by the oligopeptide permease system.

GO - Molecular functioni

  • peptide transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • protein transport Source: UniProtKB-KW
  • tripeptide transport Source: EcoliWiki

Keywordsi

Biological processPeptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G6665-MONOMER
MetaCyc:G6665-MONOMER

Protein family/group databases

TCDBi3.A.1.5.1 the atp-binding cassette (abc) superfamily
3.A.1.5.41 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Periplasmic murein peptide-binding protein
Gene namesi
Name:mppA
Synonyms:ynaH
Ordered Locus Names:b1329, JW1322
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13376 mppA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000003179223 – 537Periplasmic murein peptide-binding proteinAdd BLAST515

Proteomic databases

EPDiP77348
PaxDbiP77348
PRIDEiP77348

2D gel databases

SWISS-2DPAGEiP77348

Interactioni

Protein-protein interaction databases

BioGridi4260155, 288 interactors
STRINGi316385.ECDH10B_1449

Structurei

Secondary structure

1537
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP77348
SMRiP77348
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77348

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4107QSI Bacteria
COG4166 LUCA
HOGENOMiHOG000179191
InParanoidiP77348
KOiK15580
PhylomeDBiP77348

Family and domain databases

InterProiView protein in InterPro
IPR030678 Peptide/Ni-bd
IPR039424 SBP_5
IPR023765 SBP_5_CS
IPR000914 SBP_5_dom
PANTHERiPTHR30290 PTHR30290, 1 hit
PfamiView protein in Pfam
PF00496 SBP_bac_5, 1 hit
PIRSFiPIRSF002741 MppA, 1 hit
PROSITEiView protein in PROSITE
PS01040 SBP_BACTERIAL_5, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P77348-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKHSVSVTCC ALLVSSISLS YAAEVPSGTV LAEKQELVRH IKDEPASLDP
60 70 80 90 100
AKAVGLPEIQ VIRDLFEGLV NQNEKGEIVP GVATQWKSND NRIWTFTLRD
110 120 130 140 150
NAKWADGTPV TAQDFVYSWQ RLVDPKTLSP FAWFAALAGI NNAQAIIDGK
160 170 180 190 200
ATPDQLGVTA VDAHTLKIQL DKPLPWFVNL TANFAFFPVQ KANVESGKEW
210 220 230 240 250
TKPGNLIGNG AYVLKERVVN EKLVVVPNTH YWDNAKTVLQ KVTFLPINQE
260 270 280 290 300
SAATKRYLAG DIDITESFPK NMYQKLLKDI PGQVYTPPQL GTYYYAFNTQ
310 320 330 340 350
KGPTADQRVR LALSMTIDRR LMTEKVLGTG EKPAWHFTPD VTAGFTPEPS
360 370 380 390 400
PFEQMSQEEL NAQAKTLLSA AGYGPQKPLK LTLLYNTSEN HQKIAIAVAS
410 420 430 440 450
MWKKNLGVDV KLQNQEWKTY IDSRNTGNFD VIRASWVGDY NEPSTFLTLL
460 470 480 490 500
TSTHSGNISR FNNPAYDKVL AQASTENTVK ARNADYNAAE KILMEQAPIA
510 520 530
PIYQYTNGRL IKPWLKGYPI NNPEDVAYSR TMYIVKH
Length:537
Mass (Da):59,900
Last modified:December 15, 1998 - v2
Checksum:iC6A17656836DC3AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88242 Genomic DNA Translation: AAC38216.1
U00096 Genomic DNA Translation: AAC74411.2
AP009048 Genomic DNA Translation: BAA14922.2
PIRiD64882
RefSeqiNP_415845.2, NC_000913.3
WP_000683020.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74411; AAC74411; b1329
BAA14922; BAA14922; BAA14922
GeneIDi945951
KEGGiecj:JW1322
eco:b1329
PATRICifig|1411691.4.peg.948

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88242 Genomic DNA Translation: AAC38216.1
U00096 Genomic DNA Translation: AAC74411.2
AP009048 Genomic DNA Translation: BAA14922.2
PIRiD64882
RefSeqiNP_415845.2, NC_000913.3
WP_000683020.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3O9PX-ray2.07A23-537[»]
4TOZX-ray1.50A/B23-537[»]
ProteinModelPortaliP77348
SMRiP77348
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260155, 288 interactors
STRINGi316385.ECDH10B_1449

Protein family/group databases

TCDBi3.A.1.5.1 the atp-binding cassette (abc) superfamily
3.A.1.5.41 the atp-binding cassette (abc) superfamily

2D gel databases

SWISS-2DPAGEiP77348

Proteomic databases

EPDiP77348
PaxDbiP77348
PRIDEiP77348

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74411; AAC74411; b1329
BAA14922; BAA14922; BAA14922
GeneIDi945951
KEGGiecj:JW1322
eco:b1329
PATRICifig|1411691.4.peg.948

Organism-specific databases

EchoBASEiEB3158
EcoGeneiEG13376 mppA

Phylogenomic databases

eggNOGiENOG4107QSI Bacteria
COG4166 LUCA
HOGENOMiHOG000179191
InParanoidiP77348
KOiK15580
PhylomeDBiP77348

Enzyme and pathway databases

BioCyciEcoCyc:G6665-MONOMER
MetaCyc:G6665-MONOMER

Miscellaneous databases

EvolutionaryTraceiP77348
PROiPR:P77348

Family and domain databases

InterProiView protein in InterPro
IPR030678 Peptide/Ni-bd
IPR039424 SBP_5
IPR023765 SBP_5_CS
IPR000914 SBP_5_dom
PANTHERiPTHR30290 PTHR30290, 1 hit
PfamiView protein in Pfam
PF00496 SBP_bac_5, 1 hit
PIRSFiPIRSF002741 MppA, 1 hit
PROSITEiView protein in PROSITE
PS01040 SBP_BACTERIAL_5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMPPA_ECOLI
AccessioniPrimary (citable) accession number: P77348
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: November 7, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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