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Protein

HTH-type transcriptional regulator PgrR

Gene

pgrR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the expression of genes involved in peptidoglycan (PG) degradation. Could play a role in switch control between recycling and degradation of PG peptides. Negatively regulates the expression of the ycjY-ymjD-ymjC-mpaA operon by binding to the PgrR-box. In addition, other genes are predicted to be under the control of PgrR, including genes related to membrane formation and function.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi21 – 40H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: EcoCyc
  • DNA binding transcription factor activity Source: GO_Central
  • sequence-specific DNA binding Source: EcoCyc

GO - Biological processi

  • bacterial-type flagellum-dependent swarming motility Source: EcoCyc
  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: EcoCyc

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G6664-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator PgrR
Alternative name(s):
Regulator of PG recycling
Gene namesi
Name:pgrR
Synonyms:ycjZ
Ordered Locus Names:b1328, JW1321
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13923 pgrR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001057821 – 299HTH-type transcriptional regulator PgrRAdd BLAST299

Proteomic databases

PaxDbiP77333
PRIDEiP77333

Interactioni

Protein-protein interaction databases

BioGridi4260154, 13 interactors
DIPiDIP-11617N
IntActiP77333, 7 interactors
STRINGi316385.ECDH10B_1448

Structurei

3D structure databases

ProteinModelPortaliP77333
SMRiP77333
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 61HTH lysR-typePROSITE-ProRule annotationAdd BLAST58

Phylogenomic databases

eggNOGiENOG4105EQ2 Bacteria
ENOG410XRUN LUCA
HOGENOMiHOG000233519
InParanoidiP77333
OMAiPQDLTDH
PhylomeDBiP77333

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005119 LysR_subst-bd
IPR000847 Tscrpt_reg_HTH_LysR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00126 HTH_1, 1 hit
PF03466 LysR_substrate, 1 hit
PRINTSiPR00039 HTHLYSR
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50931 HTH_LYSR, 1 hit

Sequencei

Sequence statusi: Complete.

P77333-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKREEIADLM AFVVVAEERS FTRAAARLSM AQSALSQIVR RIEERLGLRL
60 70 80 90 100
LTRTTRSVVP TEAGEHLLSV LGPMLHDIDS AMASLSDLQN RPSGTIRITT
110 120 130 140 150
VEHAAKTILL PAMRTFLKSH PEIDIQLTID YGLTDVVSER FDAGVRLGGE
160 170 180 190 200
MDKDMIAIRI GPDIPMAIVG SPDYFSRRSV PTSVSQLIDH QAINLYLPTS
210 220 230 240 250
GTANRWRLIR GGREVRVRME GQLLLNTIDL IIDAAIDGHG LAYLPYDQVE
260 270 280 290
RAIKEKKLIR VLDKFTPDLP GYHLYYPHRR HAGSAFSLFI DRLKYKGAV
Length:299
Mass (Da):33,482
Last modified:February 1, 1997 - v1
Checksum:i05FB892DD7D19413
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74410.1
AP009048 Genomic DNA Translation: BAA14921.1
PIRiC64882
RefSeqiNP_415844.1, NC_000913.3
WP_000817708.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74410; AAC74410; b1328
BAA14921; BAA14921; BAA14921
GeneIDi945930
KEGGiecj:JW1321
eco:b1328
PATRICifig|511145.12.peg.1386

Similar proteinsi

Entry informationi

Entry nameiPGRR_ECOLI
AccessioniPrimary (citable) accession number: P77333
Secondary accession number(s): P76841
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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