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Protein

Hydrogenase-4 component G

Gene

hyfG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible component of hydrogenase 4.1 Publication

Cofactori

[4Fe-4S] clusterNote: Binds 1 [4Fe-4S] cluster.

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-150

Protein family/group databases

TCDBi3.D.1.9.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
Hydrogenase-4 component G (EC:1.-.-.-)
Gene namesi
Name:hyfG1 Publication
Ordered Locus Names:b2487, JW2472
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14215 hyfG

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001186261 – 555Hydrogenase-4 component GAdd BLAST555

Proteomic databases

PaxDbiP77329
PRIDEiP77329

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
groLP0A6F54EBI-548413,EBI-543750

Protein-protein interaction databases

BioGridi4260765, 3 interactors
DIPiDIP-9989N
IntActiP77329, 7 interactors
STRINGi316385.ECDH10B_2653

Structurei

3D structure databases

ProteinModelPortaliP77329
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.Curated

Phylogenomic databases

eggNOGiENOG4105CQV Bacteria
COG3261 LUCA
COG3262 LUCA
HOGENOMiHOG000228262
InParanoidiP77329
KOiK12142
OMAiRGENVHW
PhylomeDBiP77329

Family and domain databases

Gene3Di1.10.645.20, 1 hit
3.30.460.80, 1 hit
InterProiView protein in InterPro
IPR001135 NADH_Q_OxRdtase_suD
IPR038290 NADH_Q_OxRdtase_suD_sf
IPR037232 NADH_quin_OxRdtase_su_C/D-like
IPR001268 NADH_UbQ_OxRdtase_30kDa_su
IPR014029 NADH_UbQ_OxRdtase_49kDa_CS
IPR001501 Ni-dep_hyd_lsu
IPR029014 NiFe-Hase_large
PfamiView protein in Pfam
PF00329 Complex1_30kDa, 1 hit
PF00346 Complex1_49kDa, 2 hits
PF00374 NiFeSe_Hases, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001581 NADH_UbQ_OxRdtase_30kDa_su, 1 hit
SUPFAMiSSF143243 SSF143243, 1 hit
SSF56762 SSF56762, 1 hit
PROSITEiView protein in PROSITE
PS00535 COMPLEX1_49K, 1 hit

Sequencei

Sequence statusi: Complete.

P77329-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNVNSSSNRG EAILAALKTQ FPGAVLDEER QTPEQVTITV KINLLPDVVQ
60 70 80 90 100
YLYYQHDGWL PVLFGNDERT LNGHYAVYYA LSMEGAEKCW IVVKALVDAD
110 120 130 140 150
SREFPSVTPR VPAAVWGERE IRDMYGLIPV GLPDQRRLVL PDDWPEDMHP
160 170 180 190 200
LRKDAMDYRL RPEPTTDSET YPFINEGNSD ARVIPVGPLH ITSDEPGHFR
210 220 230 240 250
LFVDGEQIVD ADYRLFYVHR GMEKLAETRM GYNEVTFLSD RVCGICGFAH
260 270 280 290 300
SVAYTNSVEN ALGIEVPQRA HTIRSILLEV ERLHSHLLNL GLSCHFVGFD
310 320 330 340 350
TGFMQFFRVR EKSMTMAELL IGSRKTYGLN LIGGVRRDIL KEQRLQTLKL
360 370 380 390 400
VREMRADVSE LVEMLLATPN MEQRTQGIGI LDRQIARDLR FDHPYADYGN
410 420 430 440 450
IPKTLFTFTG GDVFSRVMVR VKETFDSLAM LEFALDNMPD TPLLTEGFSY
460 470 480 490 500
KPHAFALGFV EAPRGEDVHW SMLGDNQKLF RWRCRAATYA NWPVLRYMLR
510 520 530 540 550
GNTVSDAPLI IGSLDPCYSC TDRVTLVDVR KRQSKTVPYK EIERYGIDRN

RSPLK
Length:555
Mass (Da):63,383
Last modified:February 1, 1997 - v1
Checksum:iA5D410E6E74C05CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63654 Genomic DNA Translation: AAB88569.1
U00096 Genomic DNA Translation: AAC75540.1
AP009048 Genomic DNA Translation: BAA16375.2
PIRiF65024
RefSeqiNP_416982.1, NC_000913.3
WP_001102321.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75540; AAC75540; b2487
BAA16375; BAA16375; BAA16375
GeneIDi946964
KEGGiecj:JW2472
eco:b2487
PATRICifig|1411691.4.peg.4252

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63654 Genomic DNA Translation: AAB88569.1
U00096 Genomic DNA Translation: AAC75540.1
AP009048 Genomic DNA Translation: BAA16375.2
PIRiF65024
RefSeqiNP_416982.1, NC_000913.3
WP_001102321.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP77329
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260765, 3 interactors
DIPiDIP-9989N
IntActiP77329, 7 interactors
STRINGi316385.ECDH10B_2653

Protein family/group databases

TCDBi3.D.1.9.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Proteomic databases

PaxDbiP77329
PRIDEiP77329

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75540; AAC75540; b2487
BAA16375; BAA16375; BAA16375
GeneIDi946964
KEGGiecj:JW2472
eco:b2487
PATRICifig|1411691.4.peg.4252

Organism-specific databases

EchoBASEiEB3967
EcoGeneiEG14215 hyfG

Phylogenomic databases

eggNOGiENOG4105CQV Bacteria
COG3261 LUCA
COG3262 LUCA
HOGENOMiHOG000228262
InParanoidiP77329
KOiK12142
OMAiRGENVHW
PhylomeDBiP77329

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-150

Miscellaneous databases

PROiPR:P77329

Family and domain databases

Gene3Di1.10.645.20, 1 hit
3.30.460.80, 1 hit
InterProiView protein in InterPro
IPR001135 NADH_Q_OxRdtase_suD
IPR038290 NADH_Q_OxRdtase_suD_sf
IPR037232 NADH_quin_OxRdtase_su_C/D-like
IPR001268 NADH_UbQ_OxRdtase_30kDa_su
IPR014029 NADH_UbQ_OxRdtase_49kDa_CS
IPR001501 Ni-dep_hyd_lsu
IPR029014 NiFe-Hase_large
PfamiView protein in Pfam
PF00329 Complex1_30kDa, 1 hit
PF00346 Complex1_49kDa, 2 hits
PF00374 NiFeSe_Hases, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001581 NADH_UbQ_OxRdtase_30kDa_su, 1 hit
SUPFAMiSSF143243 SSF143243, 1 hit
SSF56762 SSF56762, 1 hit
PROSITEiView protein in PROSITE
PS00535 COMPLEX1_49K, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHYFG_ECOLI
AccessioniPrimary (citable) accession number: P77329
Secondary accession number(s): P76974
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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Main funding by: National Institutes of Health

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