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UniProtKB - P77328 (YBBY_ECOLI)

Entry version 135 (29 Sep 2021)
Sequence version 2 (01 Dec 2000)
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Protein

Putative purine permease YbbY

Gene

ybbY

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:G6282-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.40.5.1, the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative purine permease YbbY
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ybbY
Synonyms:glxB4
Ordered Locus Names:b0513, JW0501
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 17PeriplasmicSequence analysisAdd BLAST17
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 42CytoplasmicSequence analysis4
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Topological domaini64 – 68PeriplasmicSequence analysis5
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 102CytoplasmicSequence analysisAdd BLAST13
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 130PeriplasmicSequence analysis7
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 169CytoplasmicSequence analysisAdd BLAST18
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 196PeriplasmicSequence analysis6
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 230CytoplasmicSequence analysisAdd BLAST13
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Topological domaini252 – 288PeriplasmicSequence analysisAdd BLAST37
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 319CytoplasmicSequence analysis10
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Topological domaini341 – 345PeriplasmicSequence analysis5
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Topological domaini367 – 379CytoplasmicSequence analysisAdd BLAST13
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Topological domaini401 – 407PeriplasmicSequence analysis7
Transmembranei408 – 428HelicalSequence analysisAdd BLAST21
Topological domaini429 – 433CytoplasmicSequence analysis5

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001659631 – 433Putative purine permease YbbYAdd BLAST433

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P77328

PRoteomics IDEntifications database

More...PRIDEi		P77328

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By glyoxylate.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4259872, 210 interactors

Protein interaction database and analysis system

More...IntActi		P77328, 1 interactor

STRING: functional protein association networks

More...STRINGi		511145.b0513

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG2233, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_017959_0_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P77328

Database for complete collections of gene phylogenies

More...PhylomeDBi		P77328

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006043, NCS2

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00860, Xan_ur_permease, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P77328-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFNFAVSRES LLSGFQWFFF IFCNTVVVPP TLLSAFQLPQ SSLLTLTQYA 
        60         70         80         90        100
FLATALACFA QAFCGHRRAI MEGPGGLWWG TILTITLGEA SRGTPINDIA 
       110        120        130        140        150
TSLAVGIALS GVLTMLIGFS GLGHRLARLF TPSVMVLFML MLGAQLTTIF 
       160        170        180        190        200
FKGMLGLPFG IADPNFKIQL PPFALSVAVM CLVLAMIIFL PQRFARYGLL 
       210        220        230        240        250
VGTITGWLLW YFCFPSSHSL SGELHWQWFP LGSGGALSPG IILTAVITGL 
       260        270        280        290        300
VNISNTYGAI RGTDVFYPQQ GAGNTRYRRS FVATGFMTLI TVPLAVIPFS 
       310        320        330        340        350
PFVSSIGLLT QTGDYTRRSF IYGSVICLLV ALVPALTRLF CSIPLPVSSA 
       360        370        380        390        400
VMLVSYLPLL FSALVFSQQI TFTARNIYRL ALPLFVGIFL MALPPVYLQD 
       410        420        430 
LPLTLRPLLS NGLLVGILLA VLMDNLIPWE RIE
Length:433
Mass (Da):47,239
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0728F25A521B2193
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB40265 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U89279 Genomic DNA Translation: AAB93854.1
U82664 Genomic DNA Translation: AAB40265.1 Different initiation.
U00096 Genomic DNA Translation: AAC73615.2
AP009048 Genomic DNA Translation: BAE76291.1

NCBI Reference Sequences

More...RefSeqi		NP_415046.4, NC_000913.3
WP_001302767.1, NZ_SSZK01000024.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC73615; AAC73615; b0513
BAE76291; BAE76291; BAE76291

Database of genes from NCBI RefSeq genomes

More...GeneIDi		945131

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW0501
eco:b0513

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.1765

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89279 Genomic DNA Translation: AAB93854.1
U82664 Genomic DNA Translation: AAB40265.1 Different initiation.
U00096 Genomic DNA Translation: AAC73615.2
AP009048 Genomic DNA Translation: BAE76291.1
RefSeqiNP_415046.4, NC_000913.3
WP_001302767.1, NZ_SSZK01000024.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4259872, 210 interactors
IntActiP77328, 1 interactor
STRINGi511145.b0513

Protein family/group databases

TCDBi2.A.40.5.1, the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

Proteomic databases

PaxDbiP77328
PRIDEiP77328

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		945131

Genome annotation databases

EnsemblBacteriaiAAC73615; AAC73615; b0513
BAE76291; BAE76291; BAE76291
GeneIDi945131
KEGGiecj:JW0501
eco:b0513
PATRICifig|1411691.4.peg.1765

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB3385

Phylogenomic databases

eggNOGiCOG2233, Bacteria
HOGENOMiCLU_017959_0_0_6
InParanoidiP77328
PhylomeDBiP77328

Enzyme and pathway databases

BioCyciEcoCyc:G6282-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P77328

Family and domain databases

InterProiView protein in InterPro
IPR006043, NCS2
PfamiView protein in Pfam
PF00860, Xan_ur_permease, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYBBY_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P77328
Secondary accession number(s): Q2MBR5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 1, 2000
Last modified: September 29, 2021
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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