ybbY

Functionⁱ

GO - Molecular functionⁱ

xanthine transmembrane transporter activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

xanthine transport Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Enzyme and pathway databases

BioCycⁱ	EcoCyc:G6282-MONOMER

BioCycⁱ

EcoCyc:G6282-MONOMER

Protein family/group databases

TCDBⁱ	2.A.40.5.1 the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

TCDBⁱ

2.A.40.5.1 the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Putative purine permease YbbY
Gene namesⁱ	Name:ybbY Synonyms:glxB4 Ordered Locus Names:b0513, JW0501
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG13620 ybbY

EcoGeneⁱ

EG13620 ybbY

Subcellular locationⁱ

Cell inner membrane ; Multi-pass membrane protein

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 17	PeriplasmicSequence analysisAdd BLAST	17
Transmembraneⁱ	18 – 38	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	39 – 42	CytoplasmicSequence analysis	4
Transmembraneⁱ	43 – 63	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	64 – 68	PeriplasmicSequence analysis	5
Transmembraneⁱ	69 – 89	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	90 – 102	CytoplasmicSequence analysisAdd BLAST	13
Transmembraneⁱ	103 – 123	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	124 – 130	PeriplasmicSequence analysis	7
Transmembraneⁱ	131 – 151	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	152 – 169	CytoplasmicSequence analysisAdd BLAST	18
Transmembraneⁱ	170 – 190	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	191 – 196	PeriplasmicSequence analysis	6
Transmembraneⁱ	197 – 217	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	218 – 230	CytoplasmicSequence analysisAdd BLAST	13
Transmembraneⁱ	231 – 251	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	252 – 288	PeriplasmicSequence analysisAdd BLAST	37
Transmembraneⁱ	289 – 309	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	310 – 319	CytoplasmicSequence analysis	10
Transmembraneⁱ	320 – 340	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	341 – 345	PeriplasmicSequence analysis	5
Transmembraneⁱ	346 – 366	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	367 – 379	CytoplasmicSequence analysisAdd BLAST	13
Transmembraneⁱ	380 – 400	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	401 – 407	PeriplasmicSequence analysis	7
Transmembraneⁱ	408 – 428	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	429 – 433	CytoplasmicSequence analysis	5

GO - Cellular componentⁱ

integral component of plasma membrane Source: GO_Central
plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 15919996

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000165963	1 – 433	Putative purine permease YbbYAdd BLAST		433

Proteomic databases

PaxDbⁱ	P77328
PRIDEⁱ	P77328

Expressionⁱ

Inductionⁱ

By glyoxylate.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4259872, 210 interactors
STRINGⁱ	316385.ECDH10B_0469

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P77328
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4105DTE Bacteria COG2233 LUCA
HOGENOMⁱ	HOG000117723
InParanoidⁱ	P77328
OMAⁱ	GLWWGVY
PhylomeDBⁱ	P77328

Family and domain databases

InterProⁱ	View protein in InterPro IPR006043 Xant/urac/vitC
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00860 Xan_ur_permease, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P77328-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFNFAVSRES LLSGFQWFFF IFCNTVVVPP TLLSAFQLPQ SSLLTLTQYA 
        60         70         80         90        100
FLATALACFA QAFCGHRRAI MEGPGGLWWG TILTITLGEA SRGTPINDIA 
       110        120        130        140        150
TSLAVGIALS GVLTMLIGFS GLGHRLARLF TPSVMVLFML MLGAQLTTIF 
       160        170        180        190        200
FKGMLGLPFG IADPNFKIQL PPFALSVAVM CLVLAMIIFL PQRFARYGLL 
       210        220        230        240        250
VGTITGWLLW YFCFPSSHSL SGELHWQWFP LGSGGALSPG IILTAVITGL 
       260        270        280        290        300
VNISNTYGAI RGTDVFYPQQ GAGNTRYRRS FVATGFMTLI TVPLAVIPFS 
       310        320        330        340        350
PFVSSIGLLT QTGDYTRRSF IYGSVICLLV ALVPALTRLF CSIPLPVSSA 
       360        370        380        390        400
VMLVSYLPLL FSALVFSQQI TFTARNIYRL ALPLFVGIFL MALPPVYLQD 
       410        420        430 
LPLTLRPLLS NGLLVGILLA VLMDNLIPWE RIE

Length:433

Mass (Da):47,239

Last modified:December 1, 2000 - v2

Checksum:ⁱ0728F25A521B2193

GO

Sequence cautionⁱ

The sequence AAB40265 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U89279 Genomic DNA Translation: AAB93854.1 U82664 Genomic DNA Translation: AAB40265.1 Different initiation. U00096 Genomic DNA Translation: AAC73615.2 AP009048 Genomic DNA Translation: BAE76291.1
NCBI Reference Sequences More...RefSeqⁱ	NP_415046.4, NC_000913.3 WP_001302767.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC73615; AAC73615; b0513 BAE76291; BAE76291; BAE76291
GeneIDⁱ	945131
KEGGⁱ	ecj:JW0501 eco:b0513
PATRICⁱ	fig\|1411691.4.peg.1765

Protein	Similar proteins		Species	Score	Length	Source
P77328	Putative uracil transport protein		ECOLX		435	UniRef100_P77328
Putative uracil transport protein		ECO57		435
Putative purine permease YbbY		Escherichia coli H386		435
Putative purine permease YbbY		Escherichia coli M056		435
Putative purine permease YbbY		Escherichia coli M718		435
+53

Protein	Similar proteins		Species	Score	Length	Source
P77328	Putative uracil transport protein		ECOLX		435	UniRef90_P77328
Putative uracil transport protein		ECO57		435
Putative purine permease YbbY		Escherichia coli H386		435
Putative purine permease YbbY		Escherichia coli M056		435
Putative purine permease YbbY		Escherichia coli M718		435
+568

Protein	Similar proteins		Species	Score	Length	Source
P77328	Putative allantoin permease		ECOLI		484	UniRef50_P75712
Allantoin permease		ECOLX		484
Allantoin permease		Escherichia coli O111:NM str. K6722		484
Putative allantoin permease		Escherichia coli 1-110-08_S3_C1		484
Allantoin permease		Escherichia coli ATCC BAA-2209		484
+1683

Entry informationⁱ

Entry nameⁱ	YBBY_ECOLI
Accessionⁱ	P77328Primary (citable) accession number: P77328 Secondary accession number(s): Q2MBR5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	December 1, 2000
	Last modified:	March 28, 2018
	This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB - P77328 (YBBY_ECOLI)

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Putative purine permease YbbY

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

Topology

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Proteomic databases

Expressionⁱ

Inductionⁱ

Interactionⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence cautionⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P77328 (YBBY_ECOLI)

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Putative purine permease YbbY

ybbY

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ