UniProtKB - P77319 (HSCC_ECOLI)
Protein
Chaperone protein HscC
Gene
hscC
Organism
Escherichia coli (strain K12)
Status
Functioni
Probable chaperone. Has ATPase activity. Not stimulated by DnaJ.
GO - Molecular functioni
- ATPase activity Source: EcoCyc
- ATP binding Source: UniProtKB-KW
Keywordsi
Molecular function | Chaperone |
Biological process | Stress response |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:G6357-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Chaperone protein HscCAlternative name(s): Hsc62 |
Gene namesi | Name:hscC Synonyms:ybeW Ordered Locus Names:b0650, JW0645 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000078659 | 1 – 556 | Chaperone protein HscCAdd BLAST | 556 |
Proteomic databases
PaxDbi | P77319 |
PRIDEi | P77319 |
Expressioni
Inductioni
By heat shock. Activated up to a temperature of 40 degrees Celsius, after which levels decrease.
Interactioni
Binary interactionsi
P77319
With | #Exp. | IntAct |
---|---|---|
pdeK [P37649] | 3 | EBI-562084,EBI-562146 |
Protein-protein interaction databases
BioGRIDi | 4263357, 10 interactors 849603, 1 interactor |
DIPi | DIP-9942N |
IntActi | P77319, 33 interactors |
STRINGi | 511145.b0650 |
Family & Domainsi
Sequence similaritiesi
Belongs to the heat shock protein 70 family.Curated
Phylogenomic databases
eggNOGi | COG0443, Bacteria |
InParanoidi | P77319 |
PhylomeDBi | P77319 |
Family and domain databases
CDDi | cd10235, HscC_like_NBD, 1 hit |
Gene3Di | 2.60.34.10, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018181, Heat_shock_70_CS IPR042030, HscC_NBD IPR029047, HSP70_peptide-bd_sf IPR013126, Hsp_70_fam |
PANTHERi | PTHR19375, PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012, HSP70, 1 hit |
SUPFAMi | SSF100920, SSF100920, 1 hit SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00297, HSP70_1, 1 hit PS00329, HSP70_2, 1 hit PS01036, HSP70_3, 1 hit |
i Sequence
Sequence statusi: Complete.
P77319-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDNAELAIGI DLGTTNSLIA VWKDGAAQLI PNKFGEYLTP SIISMDENNH
60 70 80 90 100
ILVGKPAVSR RTSHPDKTAA LFKRAMGSNT NWRLGSDTFN APELSSLVLR
110 120 130 140 150
SLKEDAEEFL QRPIKDVVIS VPAYFSDEQR KHTRLAAELA GLNAVRLINE
160 170 180 190 200
PTAAAMAYGL HTQQNTRSLV FDLGGGTFDV TVLEYATPVI EVHASAGDNF
210 220 230 240 250
LGGEDFTHML VDEVLKRADV ARTTLNESEL AALYACVEAA KCSNQSPLHI
260 270 280 290 300
RWQYQEETRE CEFYENELED LWLPLLNRLR VPIEQALRDA RLKPSQIDSL
310 320 330 340 350
VLVGGASQMP LVQRIAVRLF GKLPYQSYDP STIVALGAAI QAACRLRSED
360 370 380 390 400
IEEVILTDIC PYSLGVEVNR QGVSGIFSPI IERNTTVPVS RVETYSTMHP
410 420 430 440 450
EQDSITVNVY QGENHKVKNN ILVESFDVPL KKTGAYQSID IRFSYDINGL
460 470 480 490 500
LEVDVLLEDG SVKSRVINHS PVTLSAQQIE ESRTRLSALK IYPRDMLINR
510 520 530 540 550
TFKAKLEELW ARALGDEREE IGRVITDFDA ALQSNDMARV DEVRRRASDY
LAIEIP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82598 Genomic DNA Translation: AAB40851.1 U00096 Genomic DNA Translation: AAC73751.1 AP009048 Genomic DNA Translation: BAA35297.1 |
PIRi | H64799 |
RefSeqi | NP_415183.1, NC_000913.3 WP_000367875.1, NZ_SSZK01000037.1 |
Genome annotation databases
EnsemblBacteriai | AAC73751; AAC73751; b0650 BAA35297; BAA35297; BAA35297 |
GeneIDi | 945218 |
KEGGi | ecj:JW0645 eco:b0650 |
PATRICi | fig|1411691.4.peg.1618 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82598 Genomic DNA Translation: AAB40851.1 U00096 Genomic DNA Translation: AAC73751.1 AP009048 Genomic DNA Translation: BAA35297.1 |
PIRi | H64799 |
RefSeqi | NP_415183.1, NC_000913.3 WP_000367875.1, NZ_SSZK01000037.1 |
3D structure databases
SMRi | P77319 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4263357, 10 interactors 849603, 1 interactor |
DIPi | DIP-9942N |
IntActi | P77319, 33 interactors |
STRINGi | 511145.b0650 |
Proteomic databases
PaxDbi | P77319 |
PRIDEi | P77319 |
Genome annotation databases
EnsemblBacteriai | AAC73751; AAC73751; b0650 BAA35297; BAA35297; BAA35297 |
GeneIDi | 945218 |
KEGGi | ecj:JW0645 eco:b0650 |
PATRICi | fig|1411691.4.peg.1618 |
Organism-specific databases
EchoBASEi | EB3417 |
Phylogenomic databases
eggNOGi | COG0443, Bacteria |
InParanoidi | P77319 |
PhylomeDBi | P77319 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6357-MONOMER |
Miscellaneous databases
PROi | PR:P77319 |
Family and domain databases
CDDi | cd10235, HscC_like_NBD, 1 hit |
Gene3Di | 2.60.34.10, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018181, Heat_shock_70_CS IPR042030, HscC_NBD IPR029047, HSP70_peptide-bd_sf IPR013126, Hsp_70_fam |
PANTHERi | PTHR19375, PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012, HSP70, 1 hit |
SUPFAMi | SSF100920, SSF100920, 1 hit SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00297, HSP70_1, 1 hit PS00329, HSP70_2, 1 hit PS01036, HSP70_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HSCC_ECOLI | |
Accessioni | P77319Primary (citable) accession number: P77319 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | February 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families