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Protein

Chaperone protein HscC

Gene

hscC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable chaperone. Has ATPase activity. Not stimulated by DnaJ.

GO - Molecular functioni

  • ATPase activity Source: EcoCyc
  • ATP binding Source: UniProtKB-KW

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6357-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein HscC
Alternative name(s):
Hsc62
Gene namesi
Name:hscC
Synonyms:ybeW
Ordered Locus Names:b0650, JW0645
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13653 hscC

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000786591 – 556Chaperone protein HscCAdd BLAST556

Proteomic databases

PaxDbiP77319
PRIDEiP77319

Expressioni

Inductioni

By heat shock. Activated up to a temperature of 40 degrees Celsius, after which levels decrease.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
pdeKP376493EBI-562084,EBI-562146

Protein-protein interaction databases

BioGridi4263357, 10 interactors
DIPiDIP-9942N
IntActiP77319, 33 interactors
STRINGi316385.ECDH10B_0719

Structurei

3D structure databases

ProteinModelPortaliP77319
SMRiP77319
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiENOG4105F7F Bacteria
COG0443 LUCA
HOGENOMiHOG000228137
InParanoidiP77319
KOiK04045
OMAiRKQTRFA
PhylomeDBiP77319

Family and domain databases

Gene3Di2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

P77319-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNAELAIGI DLGTTNSLIA VWKDGAAQLI PNKFGEYLTP SIISMDENNH
60 70 80 90 100
ILVGKPAVSR RTSHPDKTAA LFKRAMGSNT NWRLGSDTFN APELSSLVLR
110 120 130 140 150
SLKEDAEEFL QRPIKDVVIS VPAYFSDEQR KHTRLAAELA GLNAVRLINE
160 170 180 190 200
PTAAAMAYGL HTQQNTRSLV FDLGGGTFDV TVLEYATPVI EVHASAGDNF
210 220 230 240 250
LGGEDFTHML VDEVLKRADV ARTTLNESEL AALYACVEAA KCSNQSPLHI
260 270 280 290 300
RWQYQEETRE CEFYENELED LWLPLLNRLR VPIEQALRDA RLKPSQIDSL
310 320 330 340 350
VLVGGASQMP LVQRIAVRLF GKLPYQSYDP STIVALGAAI QAACRLRSED
360 370 380 390 400
IEEVILTDIC PYSLGVEVNR QGVSGIFSPI IERNTTVPVS RVETYSTMHP
410 420 430 440 450
EQDSITVNVY QGENHKVKNN ILVESFDVPL KKTGAYQSID IRFSYDINGL
460 470 480 490 500
LEVDVLLEDG SVKSRVINHS PVTLSAQQIE ESRTRLSALK IYPRDMLINR
510 520 530 540 550
TFKAKLEELW ARALGDEREE IGRVITDFDA ALQSNDMARV DEVRRRASDY

LAIEIP
Length:556
Mass (Da):61,986
Last modified:February 1, 1997 - v1
Checksum:i899EBAC81F69EF8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA Translation: AAB40851.1
U00096 Genomic DNA Translation: AAC73751.1
AP009048 Genomic DNA Translation: BAA35297.1
PIRiH64799
RefSeqiNP_415183.1, NC_000913.3
WP_000367875.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73751; AAC73751; b0650
BAA35297; BAA35297; BAA35297
GeneIDi945218
KEGGiecj:JW0645
eco:b0650
PATRICifig|1411691.4.peg.1618

Similar proteinsi

Entry informationi

Entry nameiHSCC_ECOLI
AccessioniPrimary (citable) accession number: P77319
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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