UniProtKB - P77307 (FETB_ECOLI)
Protein
Probable iron export permease protein FetB
Gene
fetB
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the ABC transporter complex FetAB, which is probably involved in iron export and enhances resistance to H2O2-mediated oxidative stress. Probably responsible for the translocation of the substrate across the membrane.1 Publication
GO - Biological processi
- cellular iron ion homeostasis Source: EcoCyc
- ion transport Source: UniProtKB-KW
Keywordsi
Biological process | Ion transport, Iron transport, Transport |
Ligand | Iron |
Enzyme and pathway databases
BioCyci | EcoCyc:G6267-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.139.2, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Probable iron export permease protein FetB |
Gene namesi | Name:fetB Synonyms:ybbM Ordered Locus Names:b0491, JW5066 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 5 | PeriplasmicSequence analysis | 5 | |
Transmembranei | 6 – 26 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 27 – 35 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 36 – 56 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 57 – 77 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 78 – 91 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 92 – 112 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 113 – 117 | PeriplasmicSequence analysis | 5 | |
Transmembranei | 118 – 138 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 139 – 191 | CytoplasmicSequence analysisAdd BLAST | 53 | |
Transmembranei | 192 – 212 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 213 – 218 | PeriplasmicSequence analysis | 6 | |
Transmembranei | 219 – 239 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 240 – 259 | CytoplasmicSequence analysisAdd BLAST | 20 |
GO - Cellular componenti
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Mutant exhibits increased sensitivity to H2O2 stress.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000217858 | 1 – 259 | Probable iron export permease protein FetBAdd BLAST | 259 |
Proteomic databases
jPOSTi | P77307 |
PaxDbi | P77307 |
PRIDEi | P77307 |
Interactioni
Subunit structurei
The complex is composed of two ATP-binding proteins (FetA) and two transmembrane proteins (FetB).
By similarityProtein-protein interaction databases
BioGRIDi | 4259852, 251 interactors |
STRINGi | 511145.b0491 |
Family & Domainsi
Sequence similaritiesi
Belongs to the UPF0014 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0390, Bacteria |
HOGENOMi | CLU_076147_1_0_6 |
InParanoidi | P77307 |
PhylomeDBi | P77307 |
Family and domain databases
InterProi | View protein in InterPro IPR005226, UPF0014_fam |
PANTHERi | PTHR30028, PTHR30028, 1 hit |
Pfami | View protein in Pfam PF03649, UPF0014, 1 hit |
TIGRFAMsi | TIGR00245, TIGR00245, 1 hit |
i Sequence
Sequence statusi: Complete.
P77307-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSHNITNES LALALMLVVV AILISHKEKL ALEKDILWSV GRAIIQLIIV
60 70 80 90 100
GYVLKYIFSV DDASLTLLMV LFICFNAAWN AQKRSKYIAK AFISSFIAIT
110 120 130 140 150
VGAGITLAVL ILSGSIEFIP MQVIPIAGMI AGNAMVAVGL CYNNLGQRVI
160 170 180 190 200
SEQQQIQEKL SLGATPKQAS AILIRDSIRA ALIPTVDSAK TVGLVSLPGM
210 220 230 240 250
MSGLIFAGID PVKAIKYQIM VTFMLLSTAS LSTIIACYLT YRKFYNSRHQ
LVVTQLKKK
Sequence cautioni
The sequence AAB40245 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82664 Genomic DNA Translation: AAB40245.1 Different initiation. U00096 Genomic DNA Translation: AAC73593.2 AP009048 Genomic DNA Translation: BAE76270.1 |
RefSeqi | NP_415024.4, NC_000913.3 WP_001295323.1, NZ_SSZK01000009.1 |
Genome annotation databases
EnsemblBacteriai | AAC73593; AAC73593; b0491 BAE76270; BAE76270; BAE76270 |
GeneIDi | 58462784 945137 |
KEGGi | ecj:JW5066 eco:b0491 |
PATRICi | fig|511145.12.peg.512 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82664 Genomic DNA Translation: AAB40245.1 Different initiation. U00096 Genomic DNA Translation: AAC73593.2 AP009048 Genomic DNA Translation: BAE76270.1 |
RefSeqi | NP_415024.4, NC_000913.3 WP_001295323.1, NZ_SSZK01000009.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4259852, 251 interactors |
STRINGi | 511145.b0491 |
Protein family/group databases
TCDBi | 3.A.1.139.2, the atp-binding cassette (abc) superfamily |
Proteomic databases
jPOSTi | P77307 |
PaxDbi | P77307 |
PRIDEi | P77307 |
Genome annotation databases
EnsemblBacteriai | AAC73593; AAC73593; b0491 BAE76270; BAE76270; BAE76270 |
GeneIDi | 58462784 945137 |
KEGGi | ecj:JW5066 eco:b0491 |
PATRICi | fig|511145.12.peg.512 |
Organism-specific databases
EchoBASEi | EB3048 |
Phylogenomic databases
eggNOGi | COG0390, Bacteria |
HOGENOMi | CLU_076147_1_0_6 |
InParanoidi | P77307 |
PhylomeDBi | P77307 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6267-MONOMER |
Miscellaneous databases
PROi | PR:P77307 |
Family and domain databases
InterProi | View protein in InterPro IPR005226, UPF0014_fam |
PANTHERi | PTHR30028, PTHR30028, 1 hit |
Pfami | View protein in Pfam PF03649, UPF0014, 1 hit |
TIGRFAMsi | TIGR00245, TIGR00245, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FETB_ECOLI | |
Accessioni | P77307Primary (citable) accession number: P77307 Secondary accession number(s): Q2MBT6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | December 15, 1998 | |
Last modified: | February 10, 2021 | |
This is version 140 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries