Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 140 (13 Nov 2019)
Sequence version 1 (01 Feb 1997)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Dipeptide and tripeptide permease A

Gene

dtpA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proton-dependent permease that transports di- and tripeptides as well as structurally related peptidomimetics such as aminocephalosporins into the cell. Has a clear preference for dipeptides and tripeptides composed of L-amino acids, and discriminates dipeptides on the basis of the position of charges within the substrate.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPeptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:B1634-MONOMER
ECOL316407:JW1626-MONOMER
MetaCyc:B1634-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.3.43 2026

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.17.1.2 the proton-dependent oligopeptide transporter (pot/ptr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dipeptide and tripeptide permease A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dtpA
Synonyms:tppB, ydgR
Ordered Locus Names:b1634, JW1626
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 44HelicalSequence analysisAdd BLAST23
Topological domaini45 – 59PeriplasmicSequence analysisAdd BLAST15
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 89CytoplasmicSequence analysis9
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Topological domaini111PeriplasmicSequence analysis1
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 153CytoplasmicSequence analysisAdd BLAST21
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 178PeriplasmicSequence analysis4
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 219CytoplasmicSequence analysisAdd BLAST20
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Topological domaini241 – 246PeriplasmicSequence analysis6
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Topological domaini268 – 274CytoplasmicSequence analysis7
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Topological domaini296 – 320PeriplasmicSequence analysisAdd BLAST25
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Topological domaini342 – 352CytoplasmicSequence analysisAdd BLAST11
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Topological domaini374 – 378PeriplasmicSequence analysis5
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400 – 414CytoplasmicSequence analysisAdd BLAST15
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Topological domaini436 – 459PeriplasmicSequence analysisAdd BLAST24
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21
Topological domaini481 – 500CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000643231 – 500Dipeptide and tripeptide permease AAdd BLAST500

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P77304

PRoteomics IDEntifications database

More...
PRIDEi
P77304

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Transcriptionally activated by the EnvZ/OmpR regulatory system.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (Probable). Has a crown-like structure with a diameter of 8 nm and a central density.

Curated1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4260260, 253 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b1634

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1500
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P77304

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105DUX Bacteria
COG3104 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000243449

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P77304

KEGG Orthology (KO)

More...
KOi
K03305

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P77304

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01878 PTR2_DtpA_subfam, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023517 AA/pep_transptr_DtpA
IPR005279 Dipep/tripep_permease
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR000109 POT_fam
IPR018456 PTR2_symporter_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11654 PTHR11654, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00854 PTR2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00924 yjdL_sub1_fam, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850 MFS, 1 hit
PS01022 PTR2_1, 1 hit
PS01023 PTR2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P77304-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTANQKPTE SVSLNAFKQP KAFYLIFSIE LWERFGYYGL QGIMAVYLVK
60 70 80 90 100
QLGMSEADSI TLFSSFSALV YGLVAIGGWL GDKVLGTKRV IMLGAIVLAI
110 120 130 140 150
GYALVAWSGH DAGIVYMGMA AIAVGNGLFK ANPSSLLSTC YEKNDPRLDG
160 170 180 190 200
AFTMYYMSVN IGSFFSMIAT PWLAAKYGWS VAFALSVVGL LITIVNFAFC
210 220 230 240 250
QRWVKQYGSK PDFEPINYRN LLLTIIGVVA LIAIATWLLH NQEVARMALG
260 270 280 290 300
VVAFGIVVIF GKEAFAMKGA ARRKMIVAFI LMLEAIIFFV LYSQMPTSLN
310 320 330 340 350
FFAIRNVEHS ILGLAVEPEQ YQALNPFWII IGSPILAAIY NKMGDTLPMP
360 370 380 390 400
TKFAIGMVMC SGAFLILPLG AKFASDAGIV SVSWLVASYG LQSIGELMIS
410 420 430 440 450
GLGLAMVAQL VPQRLMGFIM GSWFLTTAGA NLIGGYVAGM MAVPDNVTDP
460 470 480 490 500
LMSLEVYGRV FLQIGVATAV IAVLMLLTAP KLHRMTQDDA ADKAAKAAVA
Length:500
Mass (Da):53,991
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFDCBE0BFC206C46
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74706.1
AP009048 Genomic DNA Translation: BAA15395.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D64920

NCBI Reference Sequences

More...
RefSeqi
NP_416151.1, NC_000913.3
WP_000100932.1, NZ_STEB01000003.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC74706; AAC74706; b1634
BAA15395; BAA15395; BAA15395

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
947436

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW1626
eco:b1634

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.626

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74706.1
AP009048 Genomic DNA Translation: BAA15395.1
PIRiD64920
RefSeqiNP_416151.1, NC_000913.3
WP_000100932.1, NZ_STEB01000003.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6GS1X-ray3.29A2-500[»]
6GS4X-ray2.65A2-500[»]
6GS7X-ray3.30A2-500[»]
SMRiP77304
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi4260260, 253 interactors
STRINGi511145.b1634

Protein family/group databases

TCDBi2.A.17.1.2 the proton-dependent oligopeptide transporter (pot/ptr) family

Proteomic databases

PaxDbiP77304
PRIDEiP77304

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P77304

Genome annotation databases

EnsemblBacteriaiAAC74706; AAC74706; b1634
BAA15395; BAA15395; BAA15395
GeneIDi947436
KEGGiecj:JW1626
eco:b1634
PATRICifig|1411691.4.peg.626

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB3698

Phylogenomic databases

eggNOGiENOG4105DUX Bacteria
COG3104 LUCA
HOGENOMiHOG000243449
InParanoidiP77304
KOiK03305
PhylomeDBiP77304

Enzyme and pathway databases

BioCyciEcoCyc:B1634-MONOMER
ECOL316407:JW1626-MONOMER
MetaCyc:B1634-MONOMER
BRENDAi3.6.3.43 2026

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P77304

Family and domain databases

HAMAPiMF_01878 PTR2_DtpA_subfam, 1 hit
InterProiView protein in InterPro
IPR023517 AA/pep_transptr_DtpA
IPR005279 Dipep/tripep_permease
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR000109 POT_fam
IPR018456 PTR2_symporter_CS
PANTHERiPTHR11654 PTHR11654, 1 hit
PfamiView protein in Pfam
PF00854 PTR2, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00924 yjdL_sub1_fam, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS01022 PTR2_1, 1 hit
PS01023 PTR2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDTPA_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P77304
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 13, 2019
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again