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UniProtKB - P77300 (XYNR_ECOLI)
Protein
HTH-type transcriptional regulator XynR
Gene
xynR
Organism
Escherichia coli (strain K12)
Status
Functioni
Involved in regulation of xylonate catabolism. Represses the expression of both yagA and yagEF operons. Binds mainly at a single site within the spacer of the bidirectional transcription units yagA and yagEF.
1 PublicationActivity regulationi
Activity may be controlled by xylonate.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 25 – 45 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 21 |
GO - Molecular functioni
- DNA binding Source: GO_Central
- DNA-binding transcription factor activity Source: GO_Central
- transcription cis-regulatory region binding Source: EcoCyc
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: EcoCyc
- single-species biofilm formation Source: EcoCyc
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:G6144-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: HTH-type transcriptional regulator XynRCuratedAlternative name(s): Regulator of xylonate catabolism1 Publication |
Gene namesi | Name:xynR1 Publication Synonyms:yagI Ordered Locus Names:b0272, JW0265 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000201769 | 1 – 252 | HTH-type transcriptional regulator XynRAdd BLAST | 252 |
Proteomic databases
jPOSTi | P77300 |
PaxDbi | P77300 |
PRIDEi | P77300 |
Expressioni
Developmental stagei
Expressed in the exponentially growing phase. Level decreases down to an undetectable level during stationary phase.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261498, 8 interactors |
IntActi | P77300, 5 interactors |
STRINGi | 511145.b0272 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 66 | HTH iclR-typePROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 81 – 250 | IclR-EDPROSITE-ProRule annotationAdd BLAST | 170 |
Phylogenomic databases
eggNOGi | COG1414, Bacteria |
HOGENOMi | CLU_062618_7_1_6 |
InParanoidi | P77300 |
PhylomeDBi | P77300 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 3.30.450.40, 1 hit |
InterProi | View protein in InterPro IPR029016, GAF-like_dom_sf IPR014757, Tscrpt_reg_IclR_C IPR005471, Tscrpt_reg_IclR_N IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF09339, HTH_IclR, 1 hit PF01614, IclR, 1 hit |
SMARTi | View protein in SMART SM00346, HTH_ICLR, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS51077, HTH_ICLR, 1 hit PS51078, ICLR_ED, 1 hit |
i Sequence
Sequence statusi: Complete.
P77300-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPIIQSVERA LQILDLFNEQ ATELKITDIS KLMGLSKSTL HSLLKTLQLH
60 70 80 90 100
GYIDQNPENG KYRLGMKLVE RGHFVVGSID IRQKAKGWLT ELSRRTGQTT
110 120 130 140 150
HLGILDGREG VYIEKIEGKL AAIAYSRIGR RLPVHATAIG KVLIAWLGEA
160 170 180 190 200
ELNALLEGYQ YTTFTPATLA SREALMSALA QTREQGYALD SEENEQGVRC
210 220 230 240 250
VAVPVWNHES RVIAALSLST LTSRVDDAEL ANFREQLQQA GLALSRALGY
PA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U70214 Genomic DNA Translation: AAB08693.1 U00096 Genomic DNA Translation: AAC73375.1 AP009048 Genomic DNA Translation: BAE76056.1 |
PIRi | H64752 |
RefSeqi | NP_414806.1, NC_000913.3 WP_001121657.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC73375; AAC73375; b0272 BAE76056; BAE76056; BAE76056 |
GeneIDi | 945016 |
KEGGi | ecj:JW0265 eco:b0272 |
PATRICi | fig|1411691.4.peg.2008 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U70214 Genomic DNA Translation: AAB08693.1 U00096 Genomic DNA Translation: AAC73375.1 AP009048 Genomic DNA Translation: BAE76056.1 |
PIRi | H64752 |
RefSeqi | NP_414806.1, NC_000913.3 WP_001121657.1, NZ_LN832404.1 |
3D structure databases
SMRi | P77300 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261498, 8 interactors |
IntActi | P77300, 5 interactors |
STRINGi | 511145.b0272 |
Proteomic databases
jPOSTi | P77300 |
PaxDbi | P77300 |
PRIDEi | P77300 |
Genome annotation databases
EnsemblBacteriai | AAC73375; AAC73375; b0272 BAE76056; BAE76056; BAE76056 |
GeneIDi | 945016 |
KEGGi | ecj:JW0265 eco:b0272 |
PATRICi | fig|1411691.4.peg.2008 |
Organism-specific databases
EchoBASEi | EB3133 |
Phylogenomic databases
eggNOGi | COG1414, Bacteria |
HOGENOMi | CLU_062618_7_1_6 |
InParanoidi | P77300 |
PhylomeDBi | P77300 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6144-MONOMER |
Miscellaneous databases
PROi | PR:P77300 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 3.30.450.40, 1 hit |
InterProi | View protein in InterPro IPR029016, GAF-like_dom_sf IPR014757, Tscrpt_reg_IclR_C IPR005471, Tscrpt_reg_IclR_N IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF09339, HTH_IclR, 1 hit PF01614, IclR, 1 hit |
SMARTi | View protein in SMART SM00346, HTH_ICLR, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS51077, HTH_ICLR, 1 hit PS51078, ICLR_ED, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | XYNR_ECOLI | |
Accessioni | P77300Primary (citable) accession number: P77300 Secondary accession number(s): Q2MCF0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | September 29, 2021 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |