mdlA

Functionⁱ

Catalytic activityⁱ

ATP + H₂O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	369 – 376	ATPPROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATP binding
Source: EcoCyc
Inferred from sequence modelⁱ
- 9593292
xenobiotic transmembrane transporting ATPase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Transport
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	EcoCyc:MDLA-MONOMER

BioCycⁱ

EcoCyc:MDLA-MONOMER

Protein family/group databases

TCDBⁱ	3.A.1.106.13 the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.106.13 the atp-binding cassette (abc) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Multidrug resistance-like ATP-binding protein MdlA (EC:3.6.3.44)
Gene namesⁱ	Name:mdlA Synonyms:mdl Ordered Locus Names:b0448, JW0438
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG11622 mdlA

EcoGeneⁱ

EG11622 mdlA

Subcellular locationⁱ

Cell inner membrane
1 Publication
Manual assertion based on experiment inⁱ
- Ref.5
  "Global topology analysis of the Escherichia coli inner membrane proteome."
  Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
  Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION.
; Multi-pass membrane protein
PROSITE-ProRule annotation
Manual assertion according to rulesⁱ
- PROSITE-ProRule:PRU00441
1 Publication
Manual assertion based on experiment inⁱ
- Ref.5
  "Global topology analysis of the Escherichia coli inner membrane proteome."
  Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
  Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION.

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	23 – 43	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	53 – 73	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	134 – 154	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	155 – 175	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	248 – 268	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	280 – 300	HelicalPROSITE-ProRule annotationAdd BLAST	21

GO - Cellular componentⁱ

integral component of membrane
Source: EcoCyc
Inferred from sequence modelⁱ
- 9593292
plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 15919996

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000092492	1 – 590	Multidrug resistance-like ATP-binding protein MdlAAdd BLAST		590

Proteomic databases

PaxDbⁱ	P77265
PRIDEⁱ	P77265

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4261677, 157 interactors
Database of interacting proteins More...DIPⁱ	DIP-10173N
IntActⁱ	P77265, 1 interactor
STRINGⁱ	316385.ECDH10B_0404

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P77265
SMRⁱ	P77265
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	18 – 303	ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST		286
Domainⁱ	337 – 570	ABC transporterPROSITE-ProRule annotationAdd BLAST		234

Sequence similaritiesⁱ

Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4105BZ1 Bacteria COG1132 LUCA
InParanoidⁱ	P77265
KEGG Orthology (KO) More...KOⁱ	K18889
OMAⁱ	MLIDPIS
PhylomeDBⁱ	P77265

Family and domain databases

Gene3Dⁱ	1.20.1560.10, 1 hit
InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR027417 P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00664 ABC_membrane, 1 hit PF00005 ABC_tran, 1 hit
SMARTⁱ	View protein in SMART SM00382 AAA, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit SSF90123 SSF90123, 1 hit
PROSITEⁱ	View protein in PROSITE PS50929 ABC_TM1F, 1 hit PS00211 ABC_TRANSPORTER_1, 1 hit PS50893 ABC_TRANSPORTER_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P77265-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRLFAQLSWY FRREWRRYLG AVALLVIIAM LQLVPPKVVG IVVDGVTEQH 
        60         70         80         90        100
FTTGQILMWI ATMVLIAVVV YLLRYVWRVL LFGASYQLAV ELREDYYRQL 
       110        120        130        140        150
SRQHPEFYLR HRTGDLMARA TNDVDRVVFA AGEGVLTLVD SLVMGCAVLI 
       160        170        180        190        200
MMSTQISWQL TLFSLLPMPV MAIMIKRNGD ALHERFKLAQ AAFSSLNDRT 
       210        220        230        240        250
QESLTSIRMI KAFGLEDRQS ALFAADAEDT GKKNMRVARI DARFDPTIYI 
       260        270        280        290        300
AIGMANLLAI GGGSWMVVQG SLTLGQLTSF MMYLGLMIWP MLALAWMFNI 
       310        320        330        340        350
VERGSAAYSR IRAMLAEAPV VNDGSEPVPE GRGELDVNIH QFTYPQTDHP 
       360        370        380        390        400
ALENVNFALK PGQMLGICGP TGSGKSTLLS LIQRHFDVSE GDIRFHDIPL 
       410        420        430        440        450
TKLQLDSWRS RLAVVSQTPF LFSDTVANNI ALGCPNATQQ EIEHVARLAS 
       460        470        480        490        500
VHDDILRLPQ GYDTEVGERG VMLSGGQKQR ISIARALLVN AEILILDDAL 
       510        520        530        540        550
SAVDGRTEHQ ILHNLRQWGQ GRTVIISAHR LSALTEASEI IVMQHGHIAQ 
       560        570        580        590
RGNHDVLAQQ SGWYRDMYRY QQLEAALDDA PENREEAVDA

Length:590

Mass (Da):66,017

Last modified:February 1, 1997 - v1

Checksum:ⁱAD1CEBE41030200D

GO

Sequence cautionⁱ

The sequence AAC36870 differs from that shown. Reason: Frameshift at position 546. Fuses together mdlA and mdlB.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	145	G → A in AAC36870 (PubMed:7904973).Curated	1
Sequence conflictⁱ	234 – 235	NM → KL in AAC36870 (PubMed:7904973).Curated	2
Sequence conflictⁱ	318	A → R in AAC36870 (PubMed:7904973).Curated	1
Sequence conflictⁱ	371	T → N in AAC36870 (PubMed:7904973).Curated	1
Sequence conflictⁱ	390	E → P in AAC36870 (PubMed:7904973).Curated	1
Sequence conflictⁱ	410 – 411	SR → TG in AAC36870 (PubMed:7904973).Curated	2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L08627 Unassigned DNA Translation: AAC36870.1 Frameshift. U82664 Genomic DNA Translation: AAB40204.1 U00096 Genomic DNA Translation: AAC73551.1 AP009048 Genomic DNA Translation: BAE76228.1
PIRⁱ	H64774
NCBI Reference Sequences More...RefSeqⁱ	NP_414982.1, NC_000913.3 WP_001235649.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC73551; AAC73551; b0448 BAE76228; BAE76228; BAE76228
GeneIDⁱ	945092
KEGGⁱ	ecj:JW0438 eco:b0448
PATRICⁱ	fig\|1411691.4.peg.1828

Protein	Similar proteins		Species	Score	Length
P77265	Fused predicted multidrug transporter subunits of ABC superfamily: ATP-binding components		ECOLX		590
Multidrug ABC transporter permease/ATP-binding protein		SHIBO		590
ABC transporter family protein		Escherichia coli 1-110-08_S3_C1		590
ABC transporter family protein		Escherichia coli 2-210-07_S3_C3		590
ATP-binding component of a transport system		Escherichia coli H386		590
+10

Protein	Similar proteins		Species	Score	Length
P77265	Fused predicted multidrug transporter subunits of ABC superfamily: ATP-binding components		ECOLX		590
Multidrug ABC transporter permease/ATP-binding protein		SHIBO		590
ABC transporter family protein		Escherichia coli 1-110-08_S3_C1		590
ABC transporter family protein		Escherichia coli 2-210-07_S3_C3		590
ATP-binding component of a transport system		Escherichia coli H386		590
+826

Protein	Similar proteins		Species	Score	Length
P77265	Fused predicted multidrug transporter subunits of ABC superfamily: ATP-binding components		ECOLX		590
Multidrug ABC transporter permease/ATP-binding protein		SHIBO		590
ABC transporter family protein		Escherichia coli 1-110-08_S3_C1		590
ABC transporter family protein		Escherichia coli 2-210-07_S3_C3		590
ATP-binding component of a transport system		Escherichia coli H386		590
+2311

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L08627 Unassigned DNA Translation: AAC36870.1 Frameshift. U82664 Genomic DNA Translation: AAB40204.1 U00096 Genomic DNA Translation: AAC73551.1 AP009048 Genomic DNA Translation: BAE76228.1
PIRⁱ	H64774
NCBI Reference Sequences More...RefSeqⁱ	NP_414982.1, NC_000913.3 WP_001235649.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P77265
SMRⁱ	P77265
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4261677, 157 interactors
Database of interacting proteins More...DIPⁱ	DIP-10173N
IntActⁱ	P77265, 1 interactor
STRINGⁱ	316385.ECDH10B_0404

Protein family/group databases

TCDBⁱ	3.A.1.106.13 the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.106.13 the atp-binding cassette (abc) superfamily

Proteomic databases

PaxDbⁱ	P77265
PRIDEⁱ	P77265

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC73551; AAC73551; b0448 BAE76228; BAE76228; BAE76228
GeneIDⁱ	945092
KEGGⁱ	ecj:JW0438 eco:b0448
PATRICⁱ	fig\|1411691.4.peg.1828

Organism-specific databases

EchoBASEⁱ	EB1579
EcoGeneⁱ	EG11622 mdlA

Phylogenomic databases

eggNOGⁱ	ENOG4105BZ1 Bacteria COG1132 LUCA
InParanoidⁱ	P77265
KEGG Orthology (KO) More...KOⁱ	K18889
OMAⁱ	MLIDPIS
PhylomeDBⁱ	P77265

Enzyme and pathway databases

BioCycⁱ	EcoCyc:MDLA-MONOMER

BioCycⁱ

EcoCyc:MDLA-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P77265

PROⁱ

PR:P77265

Family and domain databases

Gene3Dⁱ	1.20.1560.10, 1 hit
InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR027417 P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00664 ABC_membrane, 1 hit PF00005 ABC_tran, 1 hit
SMARTⁱ	View protein in SMART SM00382 AAA, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit SSF90123 SSF90123, 1 hit
PROSITEⁱ	View protein in PROSITE PS50929 ABC_TM1F, 1 hit PS00211 ABC_TRANSPORTER_1, 1 hit PS50893 ABC_TRANSPORTER_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MDLA_ECOLI
Accessionⁱ	P77265Primary (citable) accession number: P77265 Secondary accession number(s): P30751, Q2MBX8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	February 1, 1997
	Last modified:	July 18, 2018
	This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P77265 (MDLA_ECOLI)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Multidrug resistance-like ATP-binding protein MdlA

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ