UniProtKB - P77249 (SFMC_ECOLI)
Protein
Probable fimbrial chaperone SfmC
Gene
sfmC
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.1 Publication
Miscellaneous
The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication
GO - Biological processi
- cell wall organization Source: InterPro
- chaperone-mediated protein folding Source: InterPro
- pilus organization Source: InterPro
Keywordsi
Molecular function | Chaperone |
Biological process | Fimbrium biogenesis |
Enzyme and pathway databases
BioCyci | EcoCyc:G6291-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Probable fimbrial chaperone SfmC |
Gene namesi | Name:sfmC Ordered Locus Names:b0531, JW0520 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Periplasm Curated
GO - Cellular componenti
- outer membrane-bounded periplasmic space Source: InterPro
Keywords - Cellular componenti
PeriplasmPathology & Biotechi
Disruption phenotypei
Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000009275 | 24 – 230 | Probable fimbrial chaperone SfmCAdd BLAST | 207 |
Proteomic databases
PaxDbi | P77249 |
PRIDEi | P77249 |
Expressioni
Inductioni
Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4263219, 114 interactors |
IntActi | P77249, 3 interactors |
STRINGi | 511145.b0531 |
Family & Domainsi
Sequence similaritiesi
Belongs to the periplasmic pilus chaperone family.Curated
Keywords - Domaini
Immunoglobulin domain, SignalPhylogenomic databases
eggNOGi | COG3121, Bacteria |
HOGENOMi | CLU_070768_2_1_6 |
PhylomeDBi | P77249 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR008962, PapD-like_sf IPR036316, Pili_assmbl_chap_C_dom_sf IPR001829, Pili_assmbl_chaperone_bac IPR016148, Pili_assmbl_chaperone_C IPR018046, Pili_assmbl_chaperone_CS IPR016147, Pili_assmbl_chaperone_N |
Pfami | View protein in Pfam PF02753, PapD_C, 1 hit PF00345, PapD_N, 1 hit |
PRINTSi | PR00969, CHAPERONPILI |
SUPFAMi | SSF49354, SSF49354, 1 hit SSF49584, SSF49584, 1 hit |
PROSITEi | View protein in PROSITE PS00635, PILI_CHAPERONE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P77249-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMTKIKLLML IIFYLIISAS AHAAGGIALG ATRIIYPADA KQTAVWIRNS
60 70 80 90 100
HTNERFLVNS WIENSSGVKE KSFIITPPLF VSEPKSENTL RIIYTGPPLA
110 120 130 140 150
ADRESLFWMN VKTIPSVDKN ALNGRNVLQL AILSRMKLFL RPIQLQELPA
160 170 180 190 200
EAPDTLKFSR SGNYINVHNP SPFYVTLVNL QVGSQKLGNA MAAPRVNSQI
210 220 230
PLPSGVQGKL KFQTVNDYGS VTPVREVNLN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82664 Genomic DNA Translation: AAB40284.1 U82598 Genomic DNA Translation: AAB40729.1 U00096 Genomic DNA Translation: AAC73633.1 AP009048 Genomic DNA Translation: BAE76308.1 |
PIRi | B64785 |
RefSeqi | NP_415064.1, NC_000913.3 WP_000988364.1, NZ_SSZK01000024.1 |
Genome annotation databases
EnsemblBacteriai | AAC73633; AAC73633; b0531 BAE76308; BAE76308; BAE76308 |
GeneIDi | 57731368 945367 |
KEGGi | ecj:JW0520 eco:b0531 |
PATRICi | fig|1411691.4.peg.1747 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82664 Genomic DNA Translation: AAB40284.1 U82598 Genomic DNA Translation: AAB40729.1 U00096 Genomic DNA Translation: AAC73633.1 AP009048 Genomic DNA Translation: BAE76308.1 |
PIRi | B64785 |
RefSeqi | NP_415064.1, NC_000913.3 WP_000988364.1, NZ_SSZK01000024.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4263219, 114 interactors |
IntActi | P77249, 3 interactors |
STRINGi | 511145.b0531 |
Proteomic databases
PaxDbi | P77249 |
PRIDEi | P77249 |
Genome annotation databases
EnsemblBacteriai | AAC73633; AAC73633; b0531 BAE76308; BAE76308; BAE76308 |
GeneIDi | 57731368 945367 |
KEGGi | ecj:JW0520 eco:b0531 |
PATRICi | fig|1411691.4.peg.1747 |
Organism-specific databases
EchoBASEi | EB3641 |
Phylogenomic databases
eggNOGi | COG3121, Bacteria |
HOGENOMi | CLU_070768_2_1_6 |
PhylomeDBi | P77249 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6291-MONOMER |
Miscellaneous databases
PROi | PR:P77249 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR008962, PapD-like_sf IPR036316, Pili_assmbl_chap_C_dom_sf IPR001829, Pili_assmbl_chaperone_bac IPR016148, Pili_assmbl_chaperone_C IPR018046, Pili_assmbl_chaperone_CS IPR016147, Pili_assmbl_chaperone_N |
Pfami | View protein in Pfam PF02753, PapD_C, 1 hit PF00345, PapD_N, 1 hit |
PRINTSi | PR00969, CHAPERONPILI |
SUPFAMi | SSF49354, SSF49354, 1 hit SSF49584, SSF49584, 1 hit |
PROSITEi | View protein in PROSITE PS00635, PILI_CHAPERONE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SFMC_ECOLI | |
Accessioni | P77249Primary (citable) accession number: P77249 Secondary accession number(s): P77077, Q2MBP8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families