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UniProtKB - P77231 (CITG_ECOLI)
Protein
2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
Gene
citG
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A, the precursor of the prosthetic group of the holo-acyl carrier protein (gamma chain) of citrate lyase, from ATP and dephospho-CoA.
2 PublicationsCatalytic activityi
- EC:2.4.2.521 Publication
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- triphosphoribosyl-dephospho-CoA synthase activity Source: EcoCyc
GO - Biological processi
- phosphorylation Source: InterPro
- prosthetic group biosynthetic process Source: EcoCyc
Keywordsi
Molecular function | Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:G6339-MONOMER |
BRENDAi | 2.4.2.52, 2026 |
Names & Taxonomyi
Protein namesi | Recommended name: 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (EC:2.4.2.521 Publication)Short name: 2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase |
Gene namesi | Name:citG Synonyms:ybdT Ordered Locus Names:b0613, JW0605 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000214664 | 1 – 292 | 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthaseAdd BLAST | 292 |
Proteomic databases
PaxDbi | P77231 |
PRIDEi | P77231 |
Expressioni
Inductioni
Repressed by H-NS. Part of the citCDEFXG operon.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4259903, 8 interactors |
IntActi | P77231, 2 interactors |
STRINGi | 511145.b0613 |
Structurei
3D structure databases
AlphaFoldDBi | P77231 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the CitG/MdcB family.Curated
Phylogenomic databases
eggNOGi | COG1767, Bacteria |
HOGENOMi | CLU_056179_1_0_6 |
InParanoidi | P77231 |
OMAi | QSWQRPA |
PhylomeDBi | P77231 |
Family and domain databases
HAMAPi | MF_00397, CitG, 1 hit |
InterProi | View protein in InterPro IPR002736, CitG IPR017551, TriPribosyl-deP-CoA_syn_CitG |
PANTHERi | PTHR30201, PTHR30201, 1 hit |
Pfami | View protein in Pfam PF01874, CitG, 1 hit |
TIGRFAMsi | TIGR03125, citrate_citG, 1 hit |
i Sequence
Sequence statusi: Complete.
P77231-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSMPATSTKT TKLATSLIDE YALLGWRAML TEVNLSPKPG LVDRINCGAH
60 70 80 90 100
KDMALEDFHR SALAIQGWLP RFIEFGACSA EMAPEAVLHG LRPIGMACEG
110 120 130 140 150
DMFRATAGVN THKGSIFSLG LLCAAIGRLL QLNQPVTPTT VCSTAASFCR
160 170 180 190 200
GLTDRELRTN NSQLTAGQRL YQQLGLTGAR GEAEAGYPLV INHALPHYLT
210 220 230 240 250
LLDQGLDPEL ALLDTLLLLM AINGDTNVAS RGGEGGLRWL QREAQTLLQK
260 270 280 290
GGIRTPADLD YLRQFDRECI ERNLSPGGSA DLLILTWFLA QI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82598 Genomic DNA Translation: AAB40813.1 U00096 Genomic DNA Translation: AAC73714.1 AP009048 Genomic DNA Translation: BAE76353.1 |
PIRi | C64795 |
RefSeqi | NP_415146.1, NC_000913.3 WP_000062457.1, NZ_STEB01000031.1 |
Genome annotation databases
EnsemblBacteriai | AAC73714; AAC73714; b0613 BAE76353; BAE76353; BAE76353 |
GeneIDi | 946395 |
KEGGi | ecj:JW0605 eco:b0613 |
PATRICi | fig|1411691.4.peg.1655 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82598 Genomic DNA Translation: AAB40813.1 U00096 Genomic DNA Translation: AAC73714.1 AP009048 Genomic DNA Translation: BAE76353.1 |
PIRi | C64795 |
RefSeqi | NP_415146.1, NC_000913.3 WP_000062457.1, NZ_STEB01000031.1 |
3D structure databases
AlphaFoldDBi | P77231 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4259903, 8 interactors |
IntActi | P77231, 2 interactors |
STRINGi | 511145.b0613 |
Proteomic databases
PaxDbi | P77231 |
PRIDEi | P77231 |
Genome annotation databases
EnsemblBacteriai | AAC73714; AAC73714; b0613 BAE76353; BAE76353; BAE76353 |
GeneIDi | 946395 |
KEGGi | ecj:JW0605 eco:b0613 |
PATRICi | fig|1411691.4.peg.1655 |
Organism-specific databases
EchoBASEi | EB3309 |
Phylogenomic databases
eggNOGi | COG1767, Bacteria |
HOGENOMi | CLU_056179_1_0_6 |
InParanoidi | P77231 |
OMAi | QSWQRPA |
PhylomeDBi | P77231 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6339-MONOMER |
BRENDAi | 2.4.2.52, 2026 |
Miscellaneous databases
PROi | PR:P77231 |
Family and domain databases
HAMAPi | MF_00397, CitG, 1 hit |
InterProi | View protein in InterPro IPR002736, CitG IPR017551, TriPribosyl-deP-CoA_syn_CitG |
PANTHERi | PTHR30201, PTHR30201, 1 hit |
Pfami | View protein in Pfam PF01874, CitG, 1 hit |
TIGRFAMsi | TIGR03125, citrate_citG, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CITG_ECOLI | |
Accessioni | P77231Primary (citable) accession number: P77231 Secondary accession number(s): Q2MBK3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families