Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cell division protein ZipA

Gene

zipA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring (PubMed:9008158, PubMed:11847116, PubMed:22164258, PubMed:22304478, PubMed:23233671). Also required for the recruitment to the septal ring of the downstream cell division proteins FtsK, FtsQ, FtsL and FtsN (PubMed:11847116, PubMed:11948172). ZipA overproduction protects FtsZ from degradation by ClpP by preventing recognition by ClpX (PubMed:23233671). Does not affect the GTPase activity of FtsZ (PubMed:10209756).7 Publications

Miscellaneous

Has been isolated as a 91 kDa complex containing ZipA-EptA and an unidentified 24 kDa protein (PubMed:16079137), but it was shown later that there is no physical interaction between ZipA and EptA (PubMed:22304478).2 Publications

GO - Biological processi

  • division septum assembly Source: EcoliWiki

Keywordsi

Biological processCell cycle, Cell division

Enzyme and pathway databases

BioCyciEcoCyc:G7258-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein ZipAUniRule annotation
Alternative name(s):
FtsZ interacting protein A1 Publication
Gene namesi
Name:zipA1 PublicationUniRule annotation
Ordered Locus Names:b2412, JW2404
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14169 zipA

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6PeriplasmicUniRule annotation1 Publication6
Transmembranei7 – 27HelicalUniRule annotationAdd BLAST21
Topological domaini28 – 328CytoplasmicUniRule annotation1 PublicationAdd BLAST301

GO - Cellular componenti

  • cell division site Source: EcoliWiki
  • integral component of plasma membrane Source: EcoliWiki
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3954
DrugBankiDB03916 4-{2-[4-(2-Aminoethyl)Piperazin-1-Yl]Pyridin-4-Yl}-N-(3-Chloro-4-Methylphenyl)Pyrimidin-2-Amine

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002145211 – 328Cell division protein ZipAAdd BLAST328

Proteomic databases

PaxDbiP77173
PRIDEiP77173

Expressioni

Inductioni

Repressed 1.5-fold by hydroxyurea.1 Publication

Interactioni

Subunit structurei

Interacts with FtsZ via their C-terminal domains (PubMed:9008158, PubMed:10209756, PubMed:10880432, PubMed:22164258). Can form homodimers prior to association with FtsZ (PubMed:22304478).5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ftsZP0A9A65EBI-1029213,EBI-370963

Protein-protein interaction databases

BioGridi4261708, 561 interactors
DIPiDIP-1157N
IntActiP77173, 2 interactors
STRINGi316385.ECDH10B_2577

Chemistry databases

BindingDBiP77173

Structurei

Secondary structure

1328
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi193 – 200Combined sources8
Helixi209 – 218Combined sources10
Beta strandi221 – 223Combined sources3
Helixi225 – 227Combined sources3
Beta strandi228 – 234Combined sources7
Beta strandi241 – 249Combined sources9
Turni256 – 259Combined sources4
Beta strandi262 – 272Combined sources11
Beta strandi274 – 276Combined sources3
Helixi278 – 296Combined sources19
Beta strandi299 – 301Combined sources3
Beta strandi305 – 307Combined sources3
Helixi310 – 326Combined sources17

3D structure databases

DisProtiDP00161
ProteinModelPortaliP77173
SMRiP77173
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77173

Family & Domainsi

Domaini

Contains an N-terminal transmembrane domain, followed by a charged domain, an unstructured P/Q domain rich in proline and glutamine, and a C-terminal FtsZ-binding domain.1 Publication

Sequence similaritiesi

Belongs to the ZipA family.UniRule annotationCurated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107NPY Bacteria
COG3115 LUCA
HOGENOMiHOG000274007
InParanoidiP77173
KOiK03528
OMAiFWSIRKQ

Family and domain databases

CDDicd00231 ZipA, 1 hit
Gene3Di3.30.1400.10, 1 hit
HAMAPiMF_00509 ZipA, 1 hit
InterProiView protein in InterPro
IPR011919 Cell_div_ZipA
IPR007449 ZipA_FtsZ-bd_C
IPR036765 ZipA_FtsZ-bd_C_sf
PANTHERiPTHR38685 PTHR38685, 1 hit
PfamiView protein in Pfam
PF04354 ZipA_C, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD035754 ZipA_Fts_Z_bd_C, 1 hit
SMARTiView protein in SMART
SM00771 ZipA_C, 1 hit
SUPFAMiSSF64383 SSF64383, 1 hit
TIGRFAMsiTIGR02205 septum_zipA, 1 hit

Sequencei

Sequence statusi: Complete.

P77173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMQDLRLILI IVGAIAIIAL LVHGFWTSRK ERSSMFRDRP LKRMKSKRDD
60 70 80 90 100
DSYDEDVEDD EGVGEVRVHR VNHAPANAQE HEAARPSPQH QYQPPYASAQ
110 120 130 140 150
PRQPVQQPPE AQVPPQHAPH PAQPVQQPAY QPQPEQPLQQ PVSPQVAPAP
160 170 180 190 200
QPVHSAPQPA QQAFQPAEPV AAPQPEPVAE PAPVMDKPKR KEAVIIMNVA
210 220 230 240 250
AHHGSELNGE LLLNSIQQAG FIFGDMNIYH RHLSPDGSGP ALFSLANMVK
260 270 280 290 300
PGTFDPEMKD FTTPGVTIFM QVPSYGDELQ NFKLMLQSAQ HIADEVGGVV
310 320
LDDQRRMMTP QKLREYQDII REVKDANA
Length:328
Mass (Da):36,475
Last modified:August 29, 2003 - v3
Checksum:iA20F119A153A782B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti211L → A in AAB42061 (PubMed:9008158).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U74650 Genomic DNA Translation: AAB42061.1
U00096 Genomic DNA Translation: AAC75465.1
AP009048 Genomic DNA Translation: BAA16284.1
PIRiC65015
RefSeqiNP_416907.1, NC_000913.3
WP_001300494.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75465; AAC75465; b2412
BAA16284; BAA16284; BAA16284
GeneIDi946869
KEGGiecj:JW2404
eco:b2412
PATRICifig|511145.12.peg.2506

Similar proteinsi

Entry informationi

Entry nameiZIPA_ECOLI
AccessioniPrimary (citable) accession number: P77173
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 29, 2003
Last modified: March 28, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health