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Entry version 137 (08 May 2019)
Sequence version 1 (01 Feb 1997)
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Protein

Alpha-2-macroglobulin

Gene

yfhM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protects the bacterial cell from host peptidases (PubMed:18697741, PubMed:26143919, PubMed:26100869). Acts by a 'trapping' mechanism. Cleavage of the bait-region domain by host peptidases leads to a global conformational change, which results in entrapment of the host peptidase and activation of the thioester bond that covalently binds the attacking host peptidase (PubMed:26143919, PubMed:26100869). Trapped peptidases are still active except against very large substrates (PubMed:26100869). May protect the entire periplam, including the lipoproteins anchored to the periplasmic side of the outer membrane, against intruding endopeptidases (PubMed:26100869).3 Publications

Miscellaneous

Bacterial alpha-2-macroglobulins were probably acquired one or more times by horizontal gene transfer from metazoan hosts.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:G7323-MONOMER
ECOL316407:JW2504-MONOMER

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I39.008

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-2-macroglobulin2 Publications
Alternative name(s):
ECAM1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:yfhM
Ordered Locus Names:b2520, JW2504
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...
EcoGenei
EG13394 yfhM

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17PROSITE-ProRule annotationAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001377518 – 1653Alpha-2-macroglobulinAdd BLAST1636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi18N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi18S-diacylglycerol cysteinePROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1187 ↔ 1190Isoglutamyl cysteine thioester (Cys-Gln)1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Thioester bond

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P76578

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P76578

PRoteomics IDEntifications database

More...
PRIDEi
P76578

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form homooligomers.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4260803, 213 interactors

Database of interacting proteins

More...
DIPi
DIP-28064N

Protein interaction database and analysis system

More...
IntActi
P76578, 15 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b2520

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11653
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P76578

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1559 – 1589Sequence analysisAdd BLAST31

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Cleavage causes major structural rearrangement of more than half the 13-domain structure from a native to a compact induced form.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105DN3 Bacteria
COG2373 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000275932

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P76578

KEGG Orthology (KO)

More...
KOi
K06894

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P76578

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026284 A2-macglob_dom_prot_bac
IPR011625 A2M_N_BRD
IPR040639 A2MG_MG1
IPR011626 Alpha-macroglobulin_TED
IPR021868 Alpha_2_Macroglob_MG3
IPR041203 Bact_A2M_MG5
IPR041462 Bact_A2M_MG6
IPR041246 Bact_MG10
IPR001599 Macroglobln_a2
IPR002890 MG2
IPR008930 Terpenoid_cyclase/PrenylTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00207 A2M, 1 hit
PF07703 A2M_BRD, 1 hit
PF17970 bMG1, 1 hit
PF17973 bMG10, 1 hit
PF11974 bMG3, 1 hit
PF17972 bMG5, 1 hit
PF17962 bMG6, 1 hit
PF01835 MG2, 1 hit
PF07678 TED_complement, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038980 A2M_bac, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48239 SSF48239, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P76578-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKLRVAACM LMLALAGCDN NDNAPTAVKK DAPSEVTKAA SSENASSAKL
60 70 80 90 100
SVPERQKLAQ QSAGKVLTLL DLSEVQLDGA ATLVLTFSIP LDPDQDFSRV
110 120 130 140 150
IHVVDKKSGK VDGAWELSDN LKELRLRHLE PKRDLIVTIG KEVKALNNAT
160 170 180 190 200
FSKDYEKTIT TRDIQPSVGF ASRGSLLPGK VVEGLPVMAL NVNNVDVNFF
210 220 230 240 250
RVKPESLPAF ISQWEYRNSL ANWQSDKLLQ MADLVYTGRF DLNPARNTRE
260 270 280 290 300
KLLLPLGDIK PLQQAGVYLA VMNQAGRYDY SNPATLFTLS DIGVSAHRYH
310 320 330 340 350
NRLDIFTQSL ENGAAQQGIE VSLLNEKGQT LTQATSDAQG HVQLENDKNA
360 370 380 390 400
ALLLARKDGQ TTLLDLKLPA LDLAEFNIAG APGYSKQFFM FGPRDLYRPG
410 420 430 440 450
ETVILNGLLR DADGKALPNQ PIKLDVIKPD GQVLRSVVSQ PENGLYHFTW
460 470 480 490 500
PLDSNAATGM WHIRANTGDN QYRMWDFHVE DFMPERMALN LTGEKTPLTP
510 520 530 540 550
KDEVKFSVVG YYLYGAPANG NTLQGQLFLR PLREAVSALP GFEFGDIAAE
560 570 580 590 600
NLSRTLDEVQ LTLDDKGRGE VSTESQWKET HSPLQVIFQG SLLESGGRPV
610 620 630 640 650
TRRAEQAIWP ADALPGIRPQ FASKSVYDYR TDSTVKQPIV DEGSNAAFDI
660 670 680 690 700
VYSDAQGVKK AVSGLQVRLI RERRDYYWNW SEDEGWQSQF DQKDLIENEQ
710 720 730 740 750
TLDLKADETG KVSFPVEWGA YRLEVKAPNE AVSSVRFWAG YSWQDNSDGS
760 770 780 790 800
GAVRPDRVTL KLDKASYRPG DTIKLHIAAP TAGKGYAMVE SSEGPLWWQE
810 820 830 840 850
IDVRAQGLDL TIPVDKTWNR HDLYLSTLVV RPGDKSRSAT PKRAVGVLHL
860 870 880 890 900
PLGDENRRLD LALETPAKMR PNQPLTVKIK ASTKNGEKPK QVNVLVSAVD
910 920 930 940 950
SGVLNITDYV TPDPWQAFFG QKRYGADIYD IYGQVIEGQG RLAALRFGGD
960 970 980 990 1000
GDELKRGGKP PVNHVNIVVQ QALPVTLNEQ GEGSVTLPIG DFNGELRVMA
1010 1020 1030 1040 1050
QAWTADDFGS NESKVIVAAP VIAELNMPRF MASGDTSRLT LDITNLTDKP
1060 1070 1080 1090 1100
QKLNVALTAS GLLELVSDSP AAVELAPGVR TTLFIPVRAL PGYGDGEIQA
1110 1120 1130 1140 1150
TISGLALPGE TVADQHKQWK IGVRPAFPAQ TVNYGTALQP GETWAIPADG
1160 1170 1180 1190 1200
LQNFSPVTLE GQLLLSGKPP LNIARYIKEL KAYPYGCLEQ TASGLFPSLY
1210 1220 1230 1240 1250
TNAAQLQALG IKGDSDEKRR ASVDIGISRL LQMQRDNGGF ALWDKNGDEE
1260 1270 1280 1290 1300
YWLTAYVMDF LVRAGEQGYS VPTDAINRGN ERLLRYLQDP GMMSIPYADN
1310 1320 1330 1340 1350
LKASKFAVQS YAALVLARQQ KAPLGALREI WEHRADAASG LPLLQLGVAL
1360 1370 1380 1390 1400
KTMGDATRGE EAIALALKTP RNSDERIWLG DYGSSLRDNA LMLSLLEENK
1410 1420 1430 1440 1450
LLPDEQYTLL NTLSQQAFGE RWLSTQESNA LFLAARTIQD LPGKWQAQTS
1460 1470 1480 1490 1500
FSAEQLTGEK AQNSNLNSDQ LVTLQVSNSG DQPLWLRMDA SGYPQSAPLP
1510 1520 1530 1540 1550
ANNVLQIERH ILGTDGKSKS LDSLRSGDLV LVWLQVKASN SVPDALVVDL
1560 1570 1580 1590 1600
LPAGLELENQ NLANGSASLE QSGGEVQNLL NQMQQASIKH IEFRDDRFVA
1610 1620 1630 1640 1650
AVAVDEYQPV TLVYLARAVT PGTYQVPQPM VESMYVPQWR ATGAAEDLLI

VRP
Length:1,653
Mass (Da):181,585
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i13109EC5CDEB41A0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC75573.1
AP009048 Genomic DNA Translation: BAE76729.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G65028

NCBI Reference Sequences

More...
RefSeqi
NP_417015.1, NC_000913.3
WP_000736312.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC75573; AAC75573; b2520
BAE76729; BAE76729; BAE76729

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
947302

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW2504
eco:b2520

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|511145.12.peg.2619

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC75573.1
AP009048 Genomic DNA Translation: BAE76729.1
PIRiG65028
RefSeqiNP_417015.1, NC_000913.3
WP_000736312.1, NZ_LN832404.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RTDX-ray3.65A23-1653[»]
4ZIQX-ray2.55A40-1653[»]
4ZIUX-ray2.70A1018-1653[»]
4ZJGX-ray2.30A40-385[»]
4ZJHX-ray1.60A163-368[»]
5A42electron microscopy16.00A40-1653[»]
SMRiP76578
ModBaseiSearch...

Protein-protein interaction databases

BioGridi4260803, 213 interactors
DIPiDIP-28064N
IntActiP76578, 15 interactors
STRINGi511145.b2520

Protein family/group databases

MEROPSiI39.008

Proteomic databases

jPOSTiP76578
PaxDbiP76578
PRIDEiP76578

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75573; AAC75573; b2520
BAE76729; BAE76729; BAE76729
GeneIDi947302
KEGGiecj:JW2504
eco:b2520
PATRICifig|511145.12.peg.2619

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB3175
EcoGeneiEG13394 yfhM

Phylogenomic databases

eggNOGiENOG4105DN3 Bacteria
COG2373 LUCA
HOGENOMiHOG000275932
InParanoidiP76578
KOiK06894
PhylomeDBiP76578

Enzyme and pathway databases

BioCyciEcoCyc:G7323-MONOMER
ECOL316407:JW2504-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P76578

Family and domain databases

InterProiView protein in InterPro
IPR026284 A2-macglob_dom_prot_bac
IPR011625 A2M_N_BRD
IPR040639 A2MG_MG1
IPR011626 Alpha-macroglobulin_TED
IPR021868 Alpha_2_Macroglob_MG3
IPR041203 Bact_A2M_MG5
IPR041462 Bact_A2M_MG6
IPR041246 Bact_MG10
IPR001599 Macroglobln_a2
IPR002890 MG2
IPR008930 Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF00207 A2M, 1 hit
PF07703 A2M_BRD, 1 hit
PF17970 bMG1, 1 hit
PF17973 bMG10, 1 hit
PF11974 bMG3, 1 hit
PF17972 bMG5, 1 hit
PF17962 bMG6, 1 hit
PF01835 MG2, 1 hit
PF07678 TED_complement, 1 hit
PIRSFiPIRSF038980 A2M_bac, 1 hit
SMARTiView protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SUPFAMiSSF48239 SSF48239, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2MG_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P76578
Secondary accession number(s): Q2MAH7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: February 1, 1997
Last modified: May 8, 2019
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
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