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UniProtKB - P76555 (EUTQ_ECOLI)
Protein
Acetate kinase EutQ
Gene
eutQ
Organism
Escherichia coli (strain K12)
Status
Functioni
A bidirectional acetate kinase that may drive flux through the ethanolamine degradation pathway under anoxic conditions. It may generate ATP that can be used by other enzymes (EutA and EutT) in the eut pathway. Might serve as an assembly hub for bacterial microcompartment (BMC) shell proteins.
By similarityCaution
In strain MG1655 the eut operon is interrupted by the CPZ-55 prophage, encoding 9 genes situated between eutA and eutB, which are translated in the other direction. CPZ-55 may prevent expression of the eut operon in strain MG1655. Strain W3110 does not have this prophage element and should be able to express the operon.1 Publication
Catalytic activityi
- EC:2.7.2.1By similarity
: ethanolamine degradation Pathwayi
This protein is involved in the pathway ethanolamine degradation, which is part of Amine and polyamine degradation.View all proteins of this organism that are known to be involved in the pathway ethanolamine degradation and in Amine and polyamine degradation.
GO - Molecular functioni
- acetate kinase activity Source: UniProtKB-EC
GO - Biological processi
- ethanolamine catabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Kinase, Transferase |
Enzyme and pathway databases
BioCyci | EcoCyc:G7290-MONOMER |
UniPathwayi | UPA00560 |
Protein family/group databases
TCDBi | 9.B.75.2.1, the ethanol utilization/transport (eut) protein family |
Names & Taxonomyi
Protein namesi | Recommended name: Acetate kinase EutQ (EC:2.7.2.1By similarity)Alternative name(s): Ethanolamine utilization protein EutQ |
Gene namesi | Name:eutQ Synonyms:ypfC Ordered Locus Names:b2460, JW2444 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Other locations
- Bacterial microcompartment By similarity
Note: May be found on the cytoplasmic face of the BMC.By similarity
Keywords - Cellular componenti
Bacterial microcompartmentPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087097 | 1 – 233 | Acetate kinase EutQAdd BLAST | 233 |
Proteomic databases
jPOSTi | P76555 |
PaxDbi | P76555 |
PRIDEi | P76555 |
Interactioni
Subunit structurei
Homodimer.
By similarityBinary interactionsi
P76555
With | #Exp. | IntAct |
---|---|---|
flxA [P77609] | 3 | EBI-553018,EBI-553024 |
Protein-protein interaction databases
BioGRIDi | 4260918, 12 interactors 851274, 5 interactors |
DIPi | DIP-9540N |
IntActi | P76555, 12 interactors |
STRINGi | 511145.b2460 |
Family & Domainsi
Sequence similaritiesi
Belongs to the EutQ cupin-like family.Curated
Phylogenomic databases
eggNOGi | COG4766, Bacteria |
HOGENOMi | CLU_082122_0_0_6 |
InParanoidi | P76555 |
PhylomeDBi | P76555 |
Family and domain databases
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR010424, EutQ IPR014710, RmlC-like_jellyroll IPR011051, RmlC_Cupin_sf |
PANTHERi | PTHR36169, PTHR36169, 1 hit |
Pfami | View protein in Pfam PF06249, EutQ, 1 hit |
SUPFAMi | SSF51182, SSF51182, 1 hit |
i Sequence
Sequence statusi: Complete.
P76555-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKLITANDI REAHARGEQA MSVVLRASII TPEAREVADL LGFTITECDE
60 70 80 90 100
SIPVTASVPA SVPADKTESQ RIRETIIAQL PEGQFTESLV AQLMEKVMKE
110 120 130 140 150
KQSLEQGAMQ PSFKSVTGKG GIKVIDGSSV KFGRFDGAEP HCVGLTDLVT
160 170 180 190 200
GDDGSSMAAG FMQWENAFFP WTLNYDEIDM VLEGELHVRH EGQTMIAKAG
210 220 230
DVMFIPKGSS IEFGTTSSVK FLYVAWPANW QSL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC75513.1 AP009048 Genomic DNA Translation: BAE76718.1 |
PIRi | C65021 |
RefSeqi | NP_416955.1, NC_000913.3 WP_000733906.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75513; AAC75513; b2460 BAE76718; BAE76718; BAE76718 |
GeneIDi | 66673679 946935 |
KEGGi | ecj:JW2444 eco:b2460 |
PATRICi | fig|511145.12.peg.2554 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC75513.1 AP009048 Genomic DNA Translation: BAE76718.1 |
PIRi | C65021 |
RefSeqi | NP_416955.1, NC_000913.3 WP_000733906.1, NZ_LN832404.1 |
3D structure databases
SMRi | P76555 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260918, 12 interactors 851274, 5 interactors |
DIPi | DIP-9540N |
IntActi | P76555, 12 interactors |
STRINGi | 511145.b2460 |
Protein family/group databases
TCDBi | 9.B.75.2.1, the ethanol utilization/transport (eut) protein family |
Proteomic databases
jPOSTi | P76555 |
PaxDbi | P76555 |
PRIDEi | P76555 |
Protocols and materials databases
DNASUi | 946935 |
Genome annotation databases
EnsemblBacteriai | AAC75513; AAC75513; b2460 BAE76718; BAE76718; BAE76718 |
GeneIDi | 66673679 946935 |
KEGGi | ecj:JW2444 eco:b2460 |
PATRICi | fig|511145.12.peg.2554 |
Organism-specific databases
EchoBASEi | EB3942 |
Phylogenomic databases
eggNOGi | COG4766, Bacteria |
HOGENOMi | CLU_082122_0_0_6 |
InParanoidi | P76555 |
PhylomeDBi | P76555 |
Enzyme and pathway databases
UniPathwayi | UPA00560 |
BioCyci | EcoCyc:G7290-MONOMER |
Miscellaneous databases
PROi | PR:P76555 |
Family and domain databases
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR010424, EutQ IPR014710, RmlC-like_jellyroll IPR011051, RmlC_Cupin_sf |
PANTHERi | PTHR36169, PTHR36169, 1 hit |
Pfami | View protein in Pfam PF06249, EutQ, 1 hit |
SUPFAMi | SSF51182, SSF51182, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EUTQ_ECOLI | |
Accessioni | P76555Primary (citable) accession number: P76555 Secondary accession number(s): Q2MAI8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | February 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families