UniProtKB - P76542 (INTZ_ECOLI)
Protein
Prophage integrase IntZ
Gene
intZ
Organism
Escherichia coli (strain K12)
Status
Functioni
Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 244 | PROSITE-ProRule annotation | 1 | |
Active sitei | 271 | PROSITE-ProRule annotation | 1 | |
Active sitei | 332 | PROSITE-ProRule annotation | 1 | |
Active sitei | 335 | PROSITE-ProRule annotation | 1 | |
Active sitei | 359 | PROSITE-ProRule annotation | 1 | |
Active sitei | 368 | O-(3'-phospho-DNA)-tyrosine intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
GO - Biological processi
- DNA integration Source: UniProtKB-KW
- DNA recombination Source: UniProtKB-KW
- establishment of integrated proviral latency Source: UniProtKB-KW
- viral entry into host cell Source: UniProtKB-KW
- viral genome integration into host DNA Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | DNA integration, DNA recombination, Viral genome integration, Virus entry into host cell |
Enzyme and pathway databases
BioCyci | EcoCyc:G7272-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Prophage integrase IntZCuratedAlternative name(s): Putative prophage CPZ-55 integrase |
Gene namesi | Name:intZ Ordered Locus Names:b2442 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000197519 | 1 – 402 | Prophage integrase IntZAdd BLAST | 402 |
Proteomic databases
PRIDEi | P76542 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 103 – 183 | Core-binding (CB)PROSITE-ProRule annotationAdd BLAST | 81 | |
Domaini | 206 – 381 | Tyr recombinasePROSITE-ProRule annotationAdd BLAST | 176 |
Sequence similaritiesi
Belongs to the 'phage' integrase family.Curated
Phylogenomic databases
eggNOGi | COG0582, Bacteria |
InParanoidi | P76542 |
PhylomeDBi | P76542 |
Family and domain databases
Gene3Di | 1.10.150.130, 1 hit 1.10.443.10, 1 hit 3.30.160.390, 1 hit |
InterProi | View protein in InterPro IPR044068, CB IPR011010, DNA_brk_join_enz IPR013762, Integrase-like_cat_sf IPR002104, Integrase_catalytic IPR038488, Integrase_DNA-bd_sf IPR025166, Integrase_DNA_bind_dom IPR010998, Integrase_recombinase_N |
Pfami | View protein in Pfam PF13356, Arm-DNA-bind_3, 1 hit PF00589, Phage_integrase, 1 hit |
SUPFAMi | SSF56349, SSF56349, 1 hit |
PROSITEi | View protein in PROSITE PS51900, CB, 1 hit PS51898, TYR_RECOMBINASE, 1 hit |
i Sequence
Sequence statusi: Complete.
P76542-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKTPLTAKA IDAAQPQDKP YKLTDSLTPG LFLLVHPNGS KYWRFRYWLN
60 70 80 90 100
KREFLQAIGV YPLITLKEAR RRATESRSLI ANGINPVEQA RKEKAIDALN
110 120 130 140 150
MAAGFKKVAE DWFATRVGGW SESYAKQVRS ALEKDVYPVL GKRSIVDITA
160 170 180 190 200
RDVLALLQKK ERTAPEQARK LRRRIGEIFK FAVITELVTR NPVADLDTAL
210 220 230 240 250
KARRPGHNAW IPISEIPAFY KALERAGSVQ IQTAIRLLIL TALRTAELRL
260 270 280 290 300
CRWEWINLED ATITLPAEVM KARRPHVVPL SRQAVELLQD QFTRSGYSAF
310 320 330 340 350
VFPGRFMDKP LSASAILKAL ERIGYKSIAT GHGWRTTFST ALNESGRYSP
360 370 380 390 400
DWIEIQLAHV PKGIRGVYNQ AAYLKQRRAM MQDYADAIDS ILAGNGNPLE
PE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC75495.2 |
PIRi | A65019 |
RefSeqi | NP_416937.2, NC_000913.3 WP_000047773.1, NZ_CP014272.1 |
Genome annotation databases
EnsemblBacteriai | AAC75495; AAC75495; b2442 |
GeneIDi | 946923 |
KEGGi | eco:b2442 |
PATRICi | fig|511145.12.peg.2537 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC75495.2 |
PIRi | A65019 |
RefSeqi | NP_416937.2, NC_000913.3 WP_000047773.1, NZ_CP014272.1 |
3D structure databases
SMRi | P76542 |
ModBasei | Search... |
Protein-protein interaction databases
DIPi | DIP-10042N |
STRINGi | 511145.b2442 |
Proteomic databases
PRIDEi | P76542 |
Genome annotation databases
EnsemblBacteriai | AAC75495; AAC75495; b2442 |
GeneIDi | 946923 |
KEGGi | eco:b2442 |
PATRICi | fig|511145.12.peg.2537 |
Organism-specific databases
EchoBASEi | EB3924 |
Phylogenomic databases
eggNOGi | COG0582, Bacteria |
InParanoidi | P76542 |
PhylomeDBi | P76542 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7272-MONOMER |
Miscellaneous databases
PROi | PR:P76542 |
Family and domain databases
Gene3Di | 1.10.150.130, 1 hit 1.10.443.10, 1 hit 3.30.160.390, 1 hit |
InterProi | View protein in InterPro IPR044068, CB IPR011010, DNA_brk_join_enz IPR013762, Integrase-like_cat_sf IPR002104, Integrase_catalytic IPR038488, Integrase_DNA-bd_sf IPR025166, Integrase_DNA_bind_dom IPR010998, Integrase_recombinase_N |
Pfami | View protein in Pfam PF13356, Arm-DNA-bind_3, 1 hit PF00589, Phage_integrase, 1 hit |
SUPFAMi | SSF56349, SSF56349, 1 hit |
PROSITEi | View protein in PROSITE PS51900, CB, 1 hit PS51898, TYR_RECOMBINASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | INTZ_ECOLI | |
Accessioni | P76542Primary (citable) accession number: P76542 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | July 15, 1999 | |
Last modified: | December 2, 2020 | |
This is version 112 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families