UniProtKB - P76524 (YPDF_ECOLI)
Protein
Aminopeptidase YpdF
Gene
ypdF
Organism
Escherichia coli (strain K12)
Status
Functioni
Hydrolyzes the N-terminal methionine when the next amino acid is alanine, proline or serine. The substrate preference for methionyl aminopeptidase activity is Pro > Ala > Ser. Also able to hydrolyze the Xaa-Pro peptide bond when the first amino acid is alanine, asparagine or methionine.1 Publication
Cofactori
GO - Molecular functioni
- aminopeptidase activity Source: EcoliWiki
- metalloaminopeptidase activity Source: EcoCyc
- transition metal ion binding Source: EcoCyc
GO - Biological processi
- proteolysis Source: EcoCyc
Keywordsi
Molecular function | Aminopeptidase, Hydrolase, Protease |
Enzyme and pathway databases
BioCyci | EcoCyc:G7248-MONOMER MetaCyc:G7248-MONOMER |
Protein family/group databases
MEROPSi | M42.008 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ypdF Ordered Locus Names:b2385, JW2382 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185105 | 1 – 361 | Aminopeptidase YpdFAdd BLAST | 361 |
Proteomic databases
PaxDbi | P76524 |
PRIDEi | P76524 |
Interactioni
Binary interactionsi
P76524
With | #Exp. | IntAct |
---|---|---|
groL [P0A6F5] | 2 | EBI-1128711,EBI-543750 |
Protein-protein interaction databases
BioGRIDi | 4259189, 26 interactors 851194, 1 interactor |
DIPi | DIP-48229N |
IntActi | P76524, 2 interactors |
STRINGi | 511145.b2385 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P76524 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase M24 family.Curated
Phylogenomic databases
eggNOGi | COG0006, Bacteria |
HOGENOMi | CLU_017266_4_0_6 |
InParanoidi | P76524 |
PhylomeDBi | P76524 |
Family and domain databases
Gene3Di | 3.40.350.10, 1 hit 3.90.230.10, 1 hit |
InterProi | View protein in InterPro IPR029149, Creatin/AminoP/Spt16_NTD IPR036005, Creatinase/aminopeptidase-like IPR000587, Creatinase_N IPR000994, Pept_M24 IPR001714, Pept_M24_MAP |
Pfami | View protein in Pfam PF01321, Creatinase_N, 1 hit PF00557, Peptidase_M24, 1 hit |
PRINTSi | PR00599, MAPEPTIDASE |
SUPFAMi | SSF53092, SSF53092, 1 hit SSF55920, SSF55920, 1 hit |
i Sequence
Sequence statusi: Complete.
P76524-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTLLASLRDW LKAQQLDAVL LSSRQNKQPH LGISTGSGYV VISRESAHIL
60 70 80 90 100
VDSRYYVEVE ARAQGYQLHL LDATNTLTTI VNQIIADEQL QTLGFEGQQV
110 120 130 140 150
SWETAHRWQS ELNAKLVSAT PDVLRQIKTP EEVEKIRLAC GIADRGAEHI
160 170 180 190 200
RRFIQAGMSE REIAAELEWF MRQQGAEKAS FDTIVASGWR GALPHGKASD
210 220 230 240 250
KIVAAGEFVT LDFGALYQGY CSDMTRTLLV NGEGVSAESH LLFNVYQIVL
260 270 280 290 300
QAQLAAISAI RPGVRCQQVD DAARRVITEA GYGDYFGHNT GHAIGIEVHE
310 320 330 340 350
DPRFSPRDTT TLQPGMLLTV EPGIYLPGQG GVRIEDVVLV TPQGAEVLYA
360
MPKTVLLTGE A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC75444.1 AP009048 Genomic DNA Translation: BAA16255.2 |
PIRi | F65012 |
RefSeqi | NP_416886.1, NC_000913.3 WP_000173288.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75444; AAC75444; b2385 BAA16255; BAA16255; BAA16255 |
GeneIDi | 946853 |
KEGGi | ecj:JW2382 eco:b2385 |
PATRICi | fig|1411691.4.peg.4343 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC75444.1 AP009048 Genomic DNA Translation: BAA16255.2 |
PIRi | F65012 |
RefSeqi | NP_416886.1, NC_000913.3 WP_000173288.1, NZ_LN832404.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5CNX | X-ray | 2.60 | A/B/C | 1-361 | [»] | |
SMRi | P76524 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4259189, 26 interactors 851194, 1 interactor |
DIPi | DIP-48229N |
IntActi | P76524, 2 interactors |
STRINGi | 511145.b2385 |
Protein family/group databases
MEROPSi | M42.008 |
Proteomic databases
PaxDbi | P76524 |
PRIDEi | P76524 |
Genome annotation databases
EnsemblBacteriai | AAC75444; AAC75444; b2385 BAA16255; BAA16255; BAA16255 |
GeneIDi | 946853 |
KEGGi | ecj:JW2382 eco:b2385 |
PATRICi | fig|1411691.4.peg.4343 |
Organism-specific databases
EchoBASEi | EB3905 |
Phylogenomic databases
eggNOGi | COG0006, Bacteria |
HOGENOMi | CLU_017266_4_0_6 |
InParanoidi | P76524 |
PhylomeDBi | P76524 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7248-MONOMER MetaCyc:G7248-MONOMER |
Miscellaneous databases
PROi | PR:P76524 |
Family and domain databases
Gene3Di | 3.40.350.10, 1 hit 3.90.230.10, 1 hit |
InterProi | View protein in InterPro IPR029149, Creatin/AminoP/Spt16_NTD IPR036005, Creatinase/aminopeptidase-like IPR000587, Creatinase_N IPR000994, Pept_M24 IPR001714, Pept_M24_MAP |
Pfami | View protein in Pfam PF01321, Creatinase_N, 1 hit PF00557, Peptidase_M24, 1 hit |
PRINTSi | PR00599, MAPEPTIDASE |
SUPFAMi | SSF53092, SSF53092, 1 hit SSF55920, SSF55920, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YPDF_ECOLI | |
Accessioni | P76524Primary (citable) accession number: P76524 Secondary accession number(s): P76951 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 27, 2002 |
Last sequence update: | February 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Peptidase families
Classification of peptidase families and list of entries