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Protein

Phosphohistidine phosphatase SixA

Gene

sixA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits phosphohistidine phosphatase activity towards the HPt domain of the ArcB sensor involved in the multistep His-Asp phosphorelay.

GO - Molecular functioni

GO - Biological processi

  • cellular protein modification process Source: EcoliWiki

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciEcoCyc:G7211-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphohistidine phosphatase SixA (EC:3.1.3.-)
Alternative name(s):
RX6
Gene namesi
Name:sixA
Synonyms:yfcW
Ordered Locus Names:b2340, JW2337
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14126 sixA

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: EcoliWiki

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002145681 – 161Phosphohistidine phosphatase SixAAdd BLAST161

Proteomic databases

PaxDbiP76502
PRIDEiP76502

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
torIQ2EES93EBI-548621,EBI-9154838

Protein-protein interaction databases

BioGridi4260532, 16 interactors
DIPiDIP-10885N
IntActiP76502, 10 interactors
STRINGi316385.ECDH10B_2503

Structurei

Secondary structure

1161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP76502
SMRiP76502
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP76502

Family & Domainsi

Sequence similaritiesi

Belongs to the SixA phosphatase family.Curated

Phylogenomic databases

eggNOGiENOG4108BY2 Bacteria
COG2062 LUCA
HOGENOMiHOG000238872
InParanoidiP76502
KOiK08296
OMAiMQVLIMR
PhylomeDBiP76502

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR004449 SixA
PfamiView protein in Pfam
PF00300 His_Phos_1, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
TIGRFAMsiTIGR00249 sixA, 1 hit

Sequencei

Sequence statusi: Complete.

P76502-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQVFIMRHGD AALDAASDSV RPLTTNGCDE SRLMANWLKG QKVEIERVLV
60 70 80 90 100
SPFLRAEQTL EEVGDCLNLP SSAEVLPELT PCGDVGLVSA YLQALTNEGV
110 120 130 140 150
ASVLVISHLP LVGYLVAELC PGETPPMFTT SAIASVTLDE SGNGTFNWQM
160
SPCNLKMAKA I
Length:161
Mass (Da):17,208
Last modified:February 1, 1997 - v1
Checksum:i98D9470A4EBAAA57
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80T → K (PubMed:9205837).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86298 Genomic DNA Translation: BAA24878.1
U00096 Genomic DNA Translation: AAC75400.1
AP009048 Genomic DNA Translation: BAA16194.2
PIRiB65007
RefSeqiNP_416842.1, NC_000913.3
WP_001195819.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75400; AAC75400; b2340
BAA16194; BAA16194; BAA16194
GeneIDi946815
KEGGiecj:JW2337
eco:b2340
PATRICifig|1411691.4.peg.4392

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86298 Genomic DNA Translation: BAA24878.1
U00096 Genomic DNA Translation: AAC75400.1
AP009048 Genomic DNA Translation: BAA16194.2
PIRiB65007
RefSeqiNP_416842.1, NC_000913.3
WP_001195819.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UJBX-ray2.06A1-161[»]
1UJCX-ray1.90A1-161[»]
ProteinModelPortaliP76502
SMRiP76502
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260532, 16 interactors
DIPiDIP-10885N
IntActiP76502, 10 interactors
STRINGi316385.ECDH10B_2503

Proteomic databases

PaxDbiP76502
PRIDEiP76502

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75400; AAC75400; b2340
BAA16194; BAA16194; BAA16194
GeneIDi946815
KEGGiecj:JW2337
eco:b2340
PATRICifig|1411691.4.peg.4392

Organism-specific databases

EchoBASEiEB3878
EcoGeneiEG14126 sixA

Phylogenomic databases

eggNOGiENOG4108BY2 Bacteria
COG2062 LUCA
HOGENOMiHOG000238872
InParanoidiP76502
KOiK08296
OMAiMQVLIMR
PhylomeDBiP76502

Enzyme and pathway databases

BioCyciEcoCyc:G7211-MONOMER

Miscellaneous databases

EvolutionaryTraceiP76502
PROiPR:P76502

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR004449 SixA
PfamiView protein in Pfam
PF00300 His_Phos_1, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
TIGRFAMsiTIGR00249 sixA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSIXA_ECOLI
AccessioniPrimary (citable) accession number: P76502
Secondary accession number(s): P77784
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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Main funding by: National Institutes of Health

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