arnD

Functionⁱ

Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (Probable).1 Publication

Catalytic activityⁱ

4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + H₂O = 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate.UniRule annotation1 Publication

Pathwayⁱ: 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate.UniRule annotation1 Publication
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase (arnC)
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD (arnD)

This subpathway is part of the pathway 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate, the pathway 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis and in Glycolipid biosynthesis.

Pathwayⁱ: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation1 Publication
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functionⁱ

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process Source: UniProtKB-UniPathway
lipid A biosynthetic process Source: UniProtKB-KW
lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
response to antibiotic Source: UniProtKB-KW
response to iron(III) ion
Source: EcoCyc
Inferred from genetic interactionⁱ
- 12139617

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Antibiotic resistance, Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCycⁱ	EcoCyc:G7169-MONOMER
UniPathwayⁱ	UPA00030 UPA00036; UER00496

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDUniRule annotation (EC:3.5.1.n3UniRule annotation)
Gene namesⁱ	Name:arnDUniRule annotation Synonyms:pmrJ, yfbH Ordered Locus Names:b2256, JW2250
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG14092 arnD

EcoGeneⁱ

EG14092 arnD

Subcellular locationⁱ

GO - Cellular componentⁱ

membrane Source: GO_Central

View the complete GO annotation on QuickGO ...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000169176	1 – 296	Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDAdd BLAST		296

Proteomic databases

PaxDbⁱ	P76472
PRIDEⁱ	P76472

Expressionⁱ

Inductionⁱ

Induced by BasR.By similarity

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4260498, 208 interactors
IntActⁱ	P76472, 1 interactor
STRINGⁱ	316385.ECDH10B_2416

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P76472
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 260	NodB homologyUniRule annotationAdd BLAST		259

Sequence similaritiesⁱ

Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105F73 Bacteria COG0726 LUCA
HOGENOMⁱ	HOG000261199
InParanoidⁱ	P76472
KEGG Orthology (KO) More...KOⁱ	K13014
OMAⁱ	KFLWKML
PhylomeDBⁱ	P76472

Family and domain databases

HAMAPⁱ	MF_01870 ArnD, 1 hit
InterProⁱ	View protein in InterPro IPR023557 ArnD IPR011330 Glyco_hydro/deAcase_b/a-brl IPR002509 NODB_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01522 Polysacc_deac_1, 1 hit
SUPFAMⁱ	SSF88713 SSF88713, 2 hits
PROSITEⁱ	View protein in PROSITE PS51677 NODB, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P76472-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTKVGLRIDV DTFRGTREGV PRLLEILSKH NIQASIFFSV GPDNMGRHLW 
        60         70         80         90        100
RLVKPQFLWK MLRSNAASLY GWDILLAGTA WPGKEIGHAN ADIIREAAKH 
       110        120        130        140        150
HEVGLHAWDH HAWQARSGNW DRQTMIDDIA RGLRTLEEII GQPVTCSAAA 
       160        170        180        190        200
GWRADQKVIE AKEAFHLRYN SDCRGAMPFR PLLESGNPGT AQIPVTLPTW 
       210        220        230        240        250
DEVIGRDVKA EDFNGWLLNR ILRDKGTPVY TIHAEVEGCA YQHNFVDLLK 
       260        270        280        290 
RAAQEGVTFC PLSELLSETL PLGQVVRGNI AGREGWLGCQ QIAGSR

Length:296

Mass (Da):33,112

Last modified:February 1, 1997 - v1

Checksum:ⁱDDD0BEE55581DE3C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U00096 Genomic DNA Translation: AAC75316.1 AP009048 Genomic DNA Translation: BAE76673.1
PIRⁱ	F64996
NCBI Reference Sequences More...RefSeqⁱ	NP_416759.1, NC_000913.3 WP_000169728.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC75316; AAC75316; b2256 BAE76673; BAE76673; BAE76673
GeneIDⁱ	945334
KEGGⁱ	ecj:JW2250 eco:b2256
PATRICⁱ	fig\|1411691.4.peg.4481

Protein	Similar proteins		Species	Score	Length
P76472	Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECO57		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECO5E		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECOLX		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECOCB		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECO5C		296
+505

Protein	Similar proteins		Species	Score	Length
P76472	Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECO57		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECO5E		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECOLX		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECOCB		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECO5C		296
+2169

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U00096 Genomic DNA Translation: AAC75316.1 AP009048 Genomic DNA Translation: BAE76673.1
PIRⁱ	F64996
NCBI Reference Sequences More...RefSeqⁱ	NP_416759.1, NC_000913.3 WP_000169728.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P76472
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4260498, 208 interactors
IntActⁱ	P76472, 1 interactor
STRINGⁱ	316385.ECDH10B_2416

Proteomic databases

PaxDbⁱ	P76472
PRIDEⁱ	P76472

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC75316; AAC75316; b2256 BAE76673; BAE76673; BAE76673
GeneIDⁱ	945334
KEGGⁱ	ecj:JW2250 eco:b2256
PATRICⁱ	fig\|1411691.4.peg.4481

Organism-specific databases

EchoBASEⁱ	EB3845
EcoGeneⁱ	EG14092 arnD

Phylogenomic databases

eggNOGⁱ	ENOG4105F73 Bacteria COG0726 LUCA
HOGENOMⁱ	HOG000261199
InParanoidⁱ	P76472
KEGG Orthology (KO) More...KOⁱ	K13014
OMAⁱ	KFLWKML
PhylomeDBⁱ	P76472

Enzyme and pathway databases

UniPathwayⁱ	UPA00030 UPA00036; UER00496
BioCycⁱ	EcoCyc:G7169-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P76472

PROⁱ

PR:P76472

Family and domain databases

HAMAPⁱ	MF_01870 ArnD, 1 hit
InterProⁱ	View protein in InterPro IPR023557 ArnD IPR011330 Glyco_hydro/deAcase_b/a-brl IPR002509 NODB_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01522 Polysacc_deac_1, 1 hit
SUPFAMⁱ	SSF88713 SSF88713, 2 hits
PROSITEⁱ	View protein in PROSITE PS51677 NODB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ARND_ECOLI
Accessionⁱ	P76472Primary (citable) accession number: P76472 Secondary accession number(s): Q2MAN3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	February 1, 1997
	Last modified:	April 25, 2018
	This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene
PATHWAY comments
Index of metabolic and biosynthesis pathways
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P76472 (ARND_ECOLI)

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Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: lipopolysaccharide biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

Pathwayⁱ: lipopolysaccharide biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ