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UniProtKB - P76460 (ATOE_ECOLI)

Entry version 138 (02 Jun 2021)
Sequence version 1 (01 Feb 1997)
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Protein

Putative short-chain fatty acid transporter

Gene

atoE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be responsible for the uptake of short-chain fatty acids.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:EG11671-MONOMER
MetaCyc:EG11671-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.73.1.1, the short chain fatty acid uptake (atoe) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative short-chain fatty acid transporter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:atoE
Ordered Locus Names:b2223, JW2217
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 19PeriplasmicSequence analysisAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 53CytoplasmicSequence analysisAdd BLAST13
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Topological domaini75 – 102PeriplasmicSequence analysisAdd BLAST28
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 137CytoplasmicSequence analysisAdd BLAST14
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180CytoplasmicSequence analysis1
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 244PeriplasmicSequence analysisAdd BLAST43
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Topological domaini287 – 313PeriplasmicSequence analysisAdd BLAST27
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Topological domaini335 – 351CytoplasmicSequence analysisAdd BLAST17
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Topological domaini373 – 394PeriplasmicSequence analysisAdd BLAST22
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Topological domaini416 – 419CytoplasmicSequence analysis4
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000647331 – 440Putative short-chain fatty acid transporterAdd BLAST440

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P76460

PRoteomics IDEntifications database

More...PRIDEi		P76460

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4261814, 7 interactors

STRING: functional protein association networks

More...STRINGi		511145.b2223

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG2031, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_037744_0_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P76460

Database for complete collections of gene phylogenies

More...PhylomeDBi		P76460

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006161, CHP00366
IPR006160, SCFA_transpt_AtoE

The PANTHER Classification System

More...PANTHERi		PTHR41983, PTHR41983, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02667, SCFA_trans, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00366, TIGR00366, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P76460-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIGRISRFMT RFVSRWLPDP LIFAMLLTLL TFVIALWLTP QTPISMVKMW 
        60         70         80         90        100
GDGFWNLLAF GMQMALIIVT GHALASSAPV KSLLRTAASA AKTPVQGVML 
       110        120        130        140        150
VTFFGSVACV INWGFGLVVG AMFAREVARR VPGSDYPLLI ACAYIGFLTW 
       160        170        180        190        200
GGGFSGSMPL LAATPGNPVE HIAGLIPVGD TLFSGFNIFI TVALIVVMPF 
       210        220        230        240        250
ITRMMMPKPS DVVSIDPKLL MEEADFQKQL PKDAPPSERL EESRILTLII 
       260        270        280        290        300
GALGIAYLAM YFSEHGFNIT INTVNLMFMI AGLLLHKTPM AYMRAISAAA 
       310        320        330        340        350
RSTAGILVQF PFYAGIQLMM EHSGLGGLIT EFFINVANKD TFPVMTFFSS 
       360        370        380        390        400
ALINFAVPSG GGHWVIQGPF VIPAAQALGA DLGKSVMAIA YGEQWMNMAQ 
       410        420        430        440
PFWALPALAI AGLGVRDIMG YCITALLFSG VIFVIGLTLF
Length:440
Mass (Da):47,528
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5C9D5ECE79F5FA71
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC75283.1
AP009048 Genomic DNA Translation: BAA16019.1

Protein sequence database of the Protein Information Resource

More...PIRi		E64992

NCBI Reference Sequences

More...RefSeqi		NP_416727.1, NC_000913.3
WP_000580275.1, NZ_STEB01000002.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC75283; AAC75283; b2223
BAA16019; BAA16019; BAA16019

Database of genes from NCBI RefSeq genomes

More...GeneIDi		946721

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW2217
eco:b2223

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.12

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC75283.1
AP009048 Genomic DNA Translation: BAA16019.1
PIRiE64992
RefSeqiNP_416727.1, NC_000913.3
WP_000580275.1, NZ_STEB01000002.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4261814, 7 interactors
STRINGi511145.b2223

Protein family/group databases

TCDBi2.A.73.1.1, the short chain fatty acid uptake (atoe) family

Proteomic databases

PaxDbiP76460
PRIDEiP76460

Genome annotation databases

EnsemblBacteriaiAAC75283; AAC75283; b2223
BAA16019; BAA16019; BAA16019
GeneIDi946721
KEGGiecj:JW2217
eco:b2223
PATRICifig|1411691.4.peg.12

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB1622

Phylogenomic databases

eggNOGiCOG2031, Bacteria
HOGENOMiCLU_037744_0_0_6
InParanoidiP76460
PhylomeDBiP76460

Enzyme and pathway databases

BioCyciEcoCyc:EG11671-MONOMER
MetaCyc:EG11671-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P76460

Family and domain databases

InterProiView protein in InterPro
IPR006161, CHP00366
IPR006160, SCFA_transpt_AtoE
PANTHERiPTHR41983, PTHR41983, 1 hit
PfamiView protein in Pfam
PF02667, SCFA_trans, 1 hit
TIGRFAMsiTIGR00366, TIGR00366, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATOE_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P76460
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 2, 2021
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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