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Protein

Acetate CoA-transferase subunit beta

Gene

atoA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.

Pathwayi: short-chain fatty acid metabolism

This protein is involved in the pathway short-chain fatty acid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway short-chain fatty acid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei46PROSITE-ProRule annotation1

GO - Molecular functioni

  • acetate CoA-transferase activity Source: EcoliWiki

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:ATOA-MONOMER
MetaCyc:ATOA-MONOMER
UniPathwayiUPA00656

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate CoA-transferase subunit beta (EC:2.8.3.8)
Alternative name(s):
Acetyl-CoA:acetoacetate CoA-transferase subunit beta
Gene namesi
Name:atoA
Ordered Locus Names:b2222, JW2216
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11670 atoA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001579151 – 216Acetate CoA-transferase subunit betaAdd BLAST216

Proteomic databases

PaxDbiP76459
PRIDEiP76459

Interactioni

Subunit structurei

Heterodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
bamDP0AC022EBI-1128061,EBI-1128087

Protein-protein interaction databases

BioGridi4262987, 8 interactors
IntActiP76459, 4 interactors
STRINGi316385.ECDH10B_2380

Structurei

Secondary structure

1216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 12Combined sources10
Beta strandi20 – 23Combined sources4
Helixi27 – 33Combined sources7
Beta strandi42 – 45Combined sources4
Turni46 – 48Combined sources3
Beta strandi49 – 53Combined sources5
Beta strandi71 – 78Combined sources8
Helixi81 – 89Combined sources9
Beta strandi94 – 98Combined sources5
Beta strandi101 – 104Combined sources4
Helixi125 – 131Combined sources7
Beta strandi133 – 138Combined sources6
Beta strandi148 – 153Combined sources6
Beta strandi159 – 162Combined sources4
Beta strandi166 – 168Combined sources3
Beta strandi170 – 177Combined sources8
Beta strandi180 – 186Combined sources7
Helixi192 – 197Combined sources6
Turni207 – 210Combined sources4

3D structure databases

ProteinModelPortaliP76459
SMRiP76459
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107QNJ Bacteria
COG2057 LUCA
HOGENOMiHOG000221245
InParanoidiP76459
KOiK01035
OMAiNWMVPGS
PhylomeDBiP76459

Family and domain databases

InterProiView protein in InterPro
IPR012791 3-oxoacid_CoA-transf_B
IPR004165 CoA_trans_fam_I
IPR004164 CoA_transf_AS
IPR037171 NagB/RpiA_transferase-like
PANTHERiPTHR13707 PTHR13707, 1 hit
PfamiView protein in Pfam
PF01144 CoA_trans, 1 hit
SMARTiView protein in SMART
SM00882 CoA_trans, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR02428 pcaJ_scoB_fam, 1 hit
PROSITEiView protein in PROSITE
PS01274 COA_TRANSF_2, 1 hit

Sequencei

Sequence statusi: Complete.

P76459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAKQRIARR VAQELRDGDI VNLGIGLPTM VANYLPEGIH ITLQSENGFL
60 70 80 90 100
GLGPVTTAHP DLVNAGGQPC GVLPGAAMFD SAMSFALIRG GHIDACVLGG
110 120 130 140 150
LQVDEEANLA NWVVPGKMVP GMGGAMDLVT GSRKVIIAME HCAKDGSAKI
160 170 180 190 200
LRRCTMPLTA QHAVHMLVTE LAVFRFIDGK MWLTEIADGC DLATVRAKTE
210
ARFEVAADLN TQRGDL
Length:216
Mass (Da):22,960
Last modified:February 1, 1997 - v1
Checksum:i3F3916D024614BAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC75282.1
AP009048 Genomic DNA Translation: BAA16018.1
PIRiD64992
RefSeqiNP_416726.1, NC_000913.3
WP_000339065.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75282; AAC75282; b2222
BAA16018; BAA16018; BAA16018
GeneIDi946719
KEGGiecj:JW2216
eco:b2222
PATRICifig|1411691.4.peg.13

Similar proteinsi

Entry informationi

Entry nameiATOA_ECOLI
AccessioniPrimary (citable) accession number: P76459
Secondary accession number(s): P94762
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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