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Entry version 150 (07 Apr 2021)
Sequence version 1 (01 Feb 1997)
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Protein

Multidrug resistance protein MdtC

Gene

mdtC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function.UniRule annotation2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:B2076-MONOMER
MetaCyc:B2076-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.6.2.12, the resistance-nodulation-cell division (rnd) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multidrug resistance protein MdtCUniRule annotation
Alternative name(s):
Multidrug transporter MdtCUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mdtCUniRule annotation
Synonyms:yegO
Ordered Locus Names:b2076, JW2061
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6CytoplasmicSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 29HelicalUniRule annotationAdd BLAST23
Topological domaini30 – 335PeriplasmicSequence analysisAdd BLAST306
Transmembranei336 – 353HelicalUniRule annotationAdd BLAST18
Topological domaini354 – 359CytoplasmicSequence analysis6
Transmembranei360 – 379HelicalUniRule annotationAdd BLAST20
Topological domaini380 – 388PeriplasmicSequence analysis9
Transmembranei389 – 411HelicalUniRule annotationAdd BLAST23
Topological domaini412 – 430CytoplasmicSequence analysisAdd BLAST19
Transmembranei431 – 453HelicalUniRule annotationAdd BLAST23
Topological domaini454 – 467PeriplasmicSequence analysisAdd BLAST14
Transmembranei468 – 490HelicalUniRule annotationAdd BLAST23
Topological domaini491 – 852CytoplasmicSequence analysisAdd BLAST362
Transmembranei853 – 875HelicalUniRule annotationAdd BLAST23
Topological domaini876 – 894PeriplasmicSequence analysisAdd BLAST19
Transmembranei895 – 917HelicalUniRule annotationAdd BLAST23
Topological domaini918 – 947CytoplasmicSequence analysisAdd BLAST30
Transmembranei948 – 970HelicalUniRule annotationAdd BLAST23
Topological domaini971 – 984PeriplasmicSequence analysisAdd BLAST14
Transmembranei985 – 1007HelicalUniRule annotationAdd BLAST23
Topological domaini1008 – 1025CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001618311 – 1025Multidrug resistance protein MdtCAdd BLAST1025

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P76399

PRoteomics IDEntifications database

More...
PRIDEi
P76399

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

The mdtABC operon is transcriptionally activated by BaeR.UniRule annotation2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtC forms a heteromultimer with MdtB.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4260422, 177 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2119, MdtABC-TolC multidrug efflux transport complex

Protein interaction database and analysis system

More...
IntActi
P76399, 4 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b2076

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P76399

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0841, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002755_1_2_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P76399

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P76399

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.2090.10, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_01424, MdtC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027463, AcrB_DN_DC_subdom
IPR001036, Acrflvin-R
IPR023931, Multidrug-R_MdtC

The PANTHER Classification System

More...
PANTHERi
PTHR32063, PTHR32063, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00873, ACR_tran, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00702, ACRIFLAVINRP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82714, SSF82714, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P76399-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFFALFIYR PVATILLSVA ITLCGILGFR MLPVAPLPQV DFPVIIVSAS
60 70 80 90 100
LPGASPETMA SSVATPLERS LGRIAGVSEM TSSSSLGSTR IILQFDFDRD
110 120 130 140 150
INGAARDVQA AINAAQSLLP SGMPSRPTYR KANPSDAPIM ILTLTSDTYS
160 170 180 190 200
QGELYDFAST QLAPTISQID GVGDVDVGGS SLPAVRVGLN PQALFNQGVS
210 220 230 240 250
LDDVRTAVSN ANVRKPQGAL EDGTHRWQIQ TNDELKTAAE YQPLIIHYNN
260 270 280 290 300
GGAVRLGDVA TVTDSVQDVR NAGMTNAKPA ILLMIRKLPE ANIIQTVDSI
310 320 330 340 350
RAKLPELQET IPAAIDLQIA QDRSPTIRAS LEEVEQTLII SVALVILVVF
360 370 380 390 400
LFLRSGRATI IPAVSVPVSL IGTFAAMYLC GFSLNNLSLM ALTIATGFVV
410 420 430 440 450
DDAIVVLENI ARHLEAGMKP LQAALQGTRE VGFTVLSMSL SLVAVFLPLL
460 470 480 490 500
LMGGLPGRLL REFAVTLSVA IGISLLVSLT LTPMMCGWML KASKPREQKR
510 520 530 540 550
LRGFGRMLVA LQQGYGKSLK WVLNHTRLVG VVLLGTIALN IWLYISIPKT
560 570 580 590 600
FFPEQDTGVL MGGIQADQSI SFQAMRGKLQ DFMKIIRDDP AVDNVTGFTG
610 620 630 640 650
GSRVNSGMMF ITLKPRDERS ETAQQIIDRL RVKLAKEPGA NLFLMAVQDI
660 670 680 690 700
RVGGRQSNAS YQYTLLSDDL AALREWEPKI RKKLATLPEL ADVNSDQQDN
710 720 730 740 750
GAEMNLVYDR DTMARLGIDV QAANSLLNNA FGQRQISTIY QPMNQYKVVM
760 770 780 790 800
EVDPRYTQDI SALEKMFVIN NEGKAIPLSY FAKWQPANAP LSVNHQGLSA
810 820 830 840 850
ASTISFNLPT GKSLSDASAA IDRAMTQLGV PSTVRGSFAG TAQVFQETMN
860 870 880 890 900
SQVILIIAAI ATVYIVLGIL YESYVHPLTI LSTLPSAGVG ALLALELFNA
910 920 930 940 950
PFSLIALIGI MLLIGIVKKN AIMMVDFALE AQRHGNLTPQ EAIFQACLLR
960 970 980 990 1000
FRPIMMTTLA ALFGALPLVL SGGDGSELRQ PLGITIVGGL VMSQLLTLYT
1010 1020
TPVVYLFFDR LRLRFSRKPK QTVTE
Length:1,025
Mass (Da):111,010
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF00BB4E7B301008
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB089189 Genomic DNA Translation: BAC06609.1
U00096 Genomic DNA Translation: AAC75137.1
AP009048 Genomic DNA Translation: BAA15932.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C64974

NCBI Reference Sequences

More...
RefSeqi
NP_416580.1, NC_000913.3
WP_000667481.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC75137; AAC75137; b2076
BAA15932; BAA15932; BAA15932

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
946608

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW2061
eco:b2076

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.174

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089189 Genomic DNA Translation: BAC06609.1
U00096 Genomic DNA Translation: AAC75137.1
AP009048 Genomic DNA Translation: BAA15932.1
PIRiC64974
RefSeqiNP_416580.1, NC_000913.3
WP_000667481.1, NZ_LN832404.1

3D structure databases

SMRiP76399
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4260422, 177 interactors
ComplexPortaliCPX-2119, MdtABC-TolC multidrug efflux transport complex
IntActiP76399, 4 interactors
STRINGi511145.b2076

Protein family/group databases

TCDBi2.A.6.2.12, the resistance-nodulation-cell division (rnd) superfamily

Proteomic databases

PaxDbiP76399
PRIDEiP76399

Genome annotation databases

EnsemblBacteriaiAAC75137; AAC75137; b2076
BAA15932; BAA15932; BAA15932
GeneIDi946608
KEGGiecj:JW2061
eco:b2076
PATRICifig|1411691.4.peg.174

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB3811

Phylogenomic databases

eggNOGiCOG0841, Bacteria
HOGENOMiCLU_002755_1_2_6
InParanoidiP76399
PhylomeDBiP76399

Enzyme and pathway databases

BioCyciEcoCyc:B2076-MONOMER
MetaCyc:B2076-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P76399

Family and domain databases

Gene3Di3.30.2090.10, 2 hits
HAMAPiMF_01424, MdtC, 1 hit
InterProiView protein in InterPro
IPR027463, AcrB_DN_DC_subdom
IPR001036, Acrflvin-R
IPR023931, Multidrug-R_MdtC
PANTHERiPTHR32063, PTHR32063, 1 hit
PfamiView protein in Pfam
PF00873, ACR_tran, 1 hit
PRINTSiPR00702, ACRIFLAVINRP
SUPFAMiSSF82714, SSF82714, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMDTC_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P76399
Secondary accession number(s): O08006
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: April 7, 2021
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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