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Protein

Multidrug resistance protein MdtA

Gene

mdtA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:MDTA
MetaCyc:MDTA

Protein family/group databases

TCDBi8.A.1.6.2 the membrane fusion protein (mfp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtA
Alternative name(s):
Multidrug transporter MdtA
Gene namesi
Name:mdtA
Synonyms:yegM
Ordered Locus Names:b2074, JW5338
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14056 mdtA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001869922 – 415Multidrug resistance protein MdtAAdd BLAST394

Proteomic databases

PaxDbiP76397
PRIDEiP76397

Expressioni

Inductioni

The mdtABC operon is transcriptionally activated by BaeR.2 Publications

Interactioni

Subunit structurei

Part of a tripartite efflux system composed of MdtA, MdtB and MdtC.

Protein-protein interaction databases

BioGridi4260423, 142 interactors
STRINGi316385.ECDH10B_2226

Structurei

3D structure databases

ProteinModelPortaliP76397
SMRiP76397
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105ENT Bacteria
ENOG410XSF7 LUCA
HOGENOMiHOG000158248
InParanoidiP76397
KOiK07799
OMAiGQLMAIH
PhylomeDBiP76397

Family and domain databases

HAMAPiMF_01422 MdtA, 1 hit
InterProiView protein in InterPro
IPR022824 Multidrug-R_MdtA
IPR006143 RND_pump_MFP
TIGRFAMsiTIGR01730 RND_mfp, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P76397-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGSYKSRWV IVIVVVIAAI AAFWFWQGRN DSRSAAPGAT KQAQQSPAGG
60 70 80 90 100
RRGMRSGPLA PVQAATAVEQ AVPRYLTGLG TITAANTVTV RSRVDGQLIA
110 120 130 140 150
LHFQEGQQVK AGDLLAEIDP SQFKVALAQA QGQLAKDKAT LANARRDLAR
160 170 180 190 200
YQQLAKTNLV SRQELDAQQA LVSETEGTIK ADEASVASAQ LQLDWSRITA
210 220 230 240 250
PVDGRVGLKQ VDVGNQISSG DTTGIVVITQ THPIDLVFTL PESDIATVVQ
260 270 280 290 300
AQKAGKPLVV EAWDRTNSKK LSEGTLLSLD NQIDATTGTI KVKARFNNQD
310 320 330 340 350
DALFPNQFVN ARMLVDTEQN AVVIPTAALQ MGNEGHFVWV LNSENKVSKH
360 370 380 390 400
LVTPGIQDSQ KVVIRAGISA GDRVVTDGID RLTEGAKVEV VEAQSATTPE
410
EKATSREYAK KGARS
Length:415
Mass (Da):44,464
Last modified:July 15, 1998 - v2
Checksum:i26240DBBE0DE1A5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089187 Genomic DNA Translation: BAC06607.1
U00096 Genomic DNA Translation: AAC75135.2
AP009048 Genomic DNA Translation: BAA15928.2
PIRiA64974
RefSeqiNP_416578.2, NC_000913.3
WP_000678989.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75135; AAC75135; b2074
BAA15928; BAA15928; BAA15928
GeneIDi946604
KEGGiecj:JW5338
eco:b2074
PATRICifig|511145.12.peg.2151

Similar proteinsi

Entry informationi

Entry nameiMDTA_ECOLI
AccessioniPrimary (citable) accession number: P76397
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: June 20, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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