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Protein

UDP-glucose 6-dehydrogenase

Gene

ugd

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathwayi: UDP-alpha-D-glucuronate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose.
Proteins known to be involved in this subpathway in this organism are:
  1. UDP-glucose 6-dehydrogenase (ugd)
This subpathway is part of the pathway UDP-alpha-D-glucuronate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose, the pathway UDP-alpha-D-glucuronate biosynthesis and in Nucleotide-sugar biosynthesis.

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei253By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi2 – 19NADSequence analysisAdd BLAST18

GO - Molecular functioni

  • NAD binding Source: InterPro
  • UDP-glucose 6-dehydrogenase activity Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciEcoCyc:UGD-MONOMER
MetaCyc:UGD-MONOMER
SABIO-RKiP76373
UniPathwayi
UPA00030

UPA00038;UER00491

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Gene namesi
Name:ugd
Synonyms:pmrE, udg, yefA
Ordered Locus Names:b2028, JW2010
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13407 ugd

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000740411 – 388UDP-glucose 6-dehydrogenaseAdd BLAST388

Post-translational modificationi

Phosphorylated on a tyrosine residue. It results in a significant increase of the dehydrogenase activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP76373
PaxDbiP76373
PRIDEiP76373

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
uvrBP0A8F82EBI-1120497,EBI-552176

Protein-protein interaction databases

BioGridi4261356, 256 interactors
IntActiP76373, 4 interactors
STRINGi316385.ECDH10B_2176

Structurei

3D structure databases

ProteinModelPortaliP76373
SMRiP76373
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C6Y Bacteria
COG1004 LUCA
HOGENOMiHOG000280378
InParanoidiP76373
KOiK00012
PhylomeDBiP76373

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028357 UDPglc_DH_bac
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500134 UDPglc_DH_bac, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit

Sequencei

Sequence statusi: Complete.

P76373-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKITISGTGY VGLSNGLLIA QNHEVVALDI LPSRVAMLND RISPIVDKEI
60 70 80 90 100
QQFLQSDKIH FNATLDKNEA YRDADYVIIA TPTDYDPKTN YFNTSSVESV
110 120 130 140 150
IKDVVEINPY AVMVIKSTVP VGFTAAMHKK YRTENIIFSP EFLREGKALY
160 170 180 190 200
DNLHPSRIVI GERSERAERF AALLQEGAIK QNIPMLFTDS TEAEAIKLFA
210 220 230 240 250
NTYLAMRVAY FNELDSYAES LGLNSRQIIE GVCLDPRIGN HYNNPSFGYG
260 270 280 290 300
GYCLPKDTKQ LLANYQSVPN NLISAIVDAN RTRKDFIADA ILSRKPQVVG
310 320 330 340 350
IYRLIMKSGS DNFRASSIQG IMKRIKAKGV EVIIYEPVMK EDSFFNSRLE
360 370 380
RDLATFKQQA DVIISNRMAE ELKDVADKVY TRDLFGSD
Length:388
Mass (Da):43,657
Last modified:February 1, 1997 - v1
Checksum:iDA33CEE3EF944AED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC75089.1
AP009048 Genomic DNA Translation: BAA15860.1
PIRiC64968
RefSeqiNP_416532.1, NC_000913.3
WP_000704857.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75089; AAC75089; b2028
BAA15860; BAA15860; BAA15860
GeneIDi946571
KEGGiecj:JW2010
eco:b2028
PATRICifig|1411691.4.peg.224

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC75089.1
AP009048 Genomic DNA Translation: BAA15860.1
PIRiC64968
RefSeqiNP_416532.1, NC_000913.3
WP_000704857.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP76373
SMRiP76373
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261356, 256 interactors
IntActiP76373, 4 interactors
STRINGi316385.ECDH10B_2176

Proteomic databases

EPDiP76373
PaxDbiP76373
PRIDEiP76373

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75089; AAC75089; b2028
BAA15860; BAA15860; BAA15860
GeneIDi946571
KEGGiecj:JW2010
eco:b2028
PATRICifig|1411691.4.peg.224

Organism-specific databases

EchoBASEiEB3183
EcoGeneiEG13407 ugd

Phylogenomic databases

eggNOGiENOG4105C6Y Bacteria
COG1004 LUCA
HOGENOMiHOG000280378
InParanoidiP76373
KOiK00012
PhylomeDBiP76373

Enzyme and pathway databases

UniPathwayi
UPA00030

UPA00038;UER00491

BioCyciEcoCyc:UGD-MONOMER
MetaCyc:UGD-MONOMER
SABIO-RKiP76373

Miscellaneous databases

PROiPR:P76373

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028357 UDPglc_DH_bac
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500134 UDPglc_DH_bac, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUDG_ECOLI
AccessioniPrimary (citable) accession number: P76373
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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