UniProtKB - P76350 (SHIA_ECOLI)
Protein
Shikimate transporter
Gene
shiA
Organism
Escherichia coli (strain K12)
Status
Functioni
GO - Molecular functioni
- shikimate transmembrane transporter activity Source: EcoCyc
- symporter activity Source: UniProtKB-KW
GO - Biological processi
- shikimate transmembrane transport Source: EcoCyc
Keywordsi
Biological process | Symport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:SHIA-MONOMER MetaCyc:SHIA-MONOMER |
Protein family/group databases
TCDBi | 2.A.1.6.6, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Shikimate transporter |
Gene namesi | Name:shiA Synonyms:yeeM Ordered Locus Names:b1981, JW1962 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- plasma membrane Source: EcoCyc
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 27 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 28 – 48 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 49 – 63 | PeriplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 64 – 84 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 85 – 108 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 109 – 129 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 130 – 132 | PeriplasmicSequence analysis | 3 | |
Transmembranei | 133 – 153 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 154 – 167 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 168 – 188 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 189 – 192 | PeriplasmicSequence analysis | 4 | |
Transmembranei | 193 – 213 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 214 – 254 | CytoplasmicSequence analysisAdd BLAST | 41 | |
Transmembranei | 255 – 275 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 276 – 286 | PeriplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 287 – 307 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 308 – 317 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 318 – 337 | Helical; Name=9Sequence analysisAdd BLAST | 20 | |
Topological domaini | 338 – 340 | PeriplasmicSequence analysis | 3 | |
Transmembranei | 341 – 363 | Helical; Name=10Sequence analysisAdd BLAST | 23 | |
Topological domaini | 364 – 386 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 387 – 407 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 408 – 410 | PeriplasmicSequence analysis | 3 | |
Transmembranei | 411 – 431 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 432 – 438 | CytoplasmicSequence analysis | 7 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050336 | 1 – 438 | Shikimate transporterAdd BLAST | 438 |
Proteomic databases
PaxDbi | P76350 |
PRIDEi | P76350 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260400, 9 interactors |
STRINGi | 511145.b1981 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0477, Bacteria |
HOGENOMi | CLU_001265_39_5_6 |
InParanoidi | P76350 |
PhylomeDBi | P76350 |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR004736, MHS_symport IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00883, 2A0106, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P76350-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSTLISTRP DEGTLSLSRA RRAALGSFAG AVVDWYDFLL YGITAALVFN
60 70 80 90 100
REFFPQVSPA MGTLAAFATF GVGFLFRPLG GVIFGHFGDR LGRKRMLMLT
110 120 130 140 150
VWMMGIATAL IGILPSFSTI GWWAPILLVT LRAIQGFAVG GEWGGAALLS
160 170 180 190 200
VESAPKNKKA FYSSGVQVGY GVGLLLSTGL VSLISMMTTD EQFLSWGWRI
210 220 230 240 250
PFLFSIVLVL GALWVRNGME ESAEFEQQQH YQAAAKKRIP VIEALLRHPG
260 270 280 290 300
AFLKIIALRL CELLTMYIVT AFALNYSTQN MGLPRELFLN IGLLVGGLSC
310 320 330 340 350
LTIPCFAWLA DRFGRRRVYI TGTLIGTLSA FPFFMALEAQ SIFWIVFFSI
360 370 380 390 400
MLANIAHDMV VCVQQPMFTE MFGASYRYSG AGVGYQVASV VGGGFTPFIA
410 420 430
AALITYFAGN WHSVAIYLLA GCLISAMTAL LMKDSQRA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U88529 Genomic DNA Translation: AAC46271.1 U00096 Genomic DNA Translation: AAC75045.1 AP009048 Genomic DNA Translation: BAA15801.1 |
PIRi | G64962 |
RefSeqi | NP_416488.1, NC_000913.3 WP_000378575.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75045; AAC75045; b1981 BAA15801; BAA15801; BAA15801 |
GeneIDi | 946495 |
KEGGi | ecj:JW1962 eco:b1981 |
PATRICi | fig|1411691.4.peg.270 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U88529 Genomic DNA Translation: AAC46271.1 U00096 Genomic DNA Translation: AAC75045.1 AP009048 Genomic DNA Translation: BAA15801.1 |
PIRi | G64962 |
RefSeqi | NP_416488.1, NC_000913.3 WP_000378575.1, NZ_LN832404.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4260400, 9 interactors |
STRINGi | 511145.b1981 |
Protein family/group databases
TCDBi | 2.A.1.6.6, the major facilitator superfamily (mfs) |
Proteomic databases
PaxDbi | P76350 |
PRIDEi | P76350 |
Genome annotation databases
EnsemblBacteriai | AAC75045; AAC75045; b1981 BAA15801; BAA15801; BAA15801 |
GeneIDi | 946495 |
KEGGi | ecj:JW1962 eco:b1981 |
PATRICi | fig|1411691.4.peg.270 |
Organism-specific databases
EchoBASEi | EB4148 |
Phylogenomic databases
eggNOGi | COG0477, Bacteria |
HOGENOMi | CLU_001265_39_5_6 |
InParanoidi | P76350 |
PhylomeDBi | P76350 |
Enzyme and pathway databases
BioCyci | EcoCyc:SHIA-MONOMER MetaCyc:SHIA-MONOMER |
Miscellaneous databases
PROi | PR:P76350 |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR004736, MHS_symport IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00883, 2A0106, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SHIA_ECOLI | |
Accessioni | P76350Primary (citable) accession number: P76350 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families