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Entry version 132 (13 Nov 2019)
Sequence version 1 (01 Feb 1997)
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Protein

Flagellar biosynthetic protein FlhB

Gene

flhB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBacterial flagellum biogenesis, Bacterial flagellum protein export, Protein transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:G7028-MONOMER
ECOL316407:JW1869-MONOMER

Protein family/group databases

MEROPS protease database

More...
MEROPSi
N06.A01

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Flagellar biosynthetic protein FlhB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:flhB
Synonyms:yecQ
Ordered Locus Names:b1880, JW1869
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 31PeriplasmicSequence analysisAdd BLAST31
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Topological domaini53 – 73CytoplasmicSequence analysisAdd BLAST21
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Topological domaini116 – 144CytoplasmicSequence analysisAdd BLAST29
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 189PeriplasmicSequence analysisAdd BLAST24
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 382CytoplasmicSequence analysisAdd BLAST172

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001809491 – 382Flagellar biosynthetic protein FlhBAdd BLAST382

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P76299

PRoteomics IDEntifications database

More...
PRIDEi
P76299

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
4260378, 21 interactors

Protein interaction database and analysis system

More...
IntActi
P76299, 3 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b1880

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P76299

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type III secretion exporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105D00 Bacteria
COG1377 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000253899

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P76299

KEGG Orthology (KO)

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KOi
K02401

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P76299

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1690.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006136 FlhB
IPR006135 T3SS_substrate_exporter
IPR029025 T3SS_substrate_exporter_C

The PANTHER Classification System

More...
PANTHERi
PTHR30531 PTHR30531, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01312 Bac_export_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00950 TYPE3IMSPROT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF160544 SSF160544, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00328 flhB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P76299-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDESDDKTE APTPHRLEKA REEGQIPRSR ELTSLLILLV GVSVIWFGGV
60 70 80 90 100
SLARRLSGML SAGLHFDHSI INDPNLILGQ IILLIREAML ALLPLISGVV
110 120 130 140 150
LVALISPVML GGLVFSGKSL QPKFSKLNPL PGIKRMFSAQ TGAELLKAIL
160 170 180 190 200
KTILVGSVTG FFLWHHWPQM MRLMAESPIT AMGNAMDLVG LCALLVVLGV
210 220 230 240 250
IPMVGFDVFF QIFSHLKKLR MSRQDIRDEF KQSEGDPHVK GRIRQMQRAA
260 270 280 290 300
ARRRMMADVP KADVIVNNPT HYSVALQYDE NKMSAPKVVA KGAGLVALRI
310 320 330 340 350
REIGAENNVP TLEAPPLARA LYRHAEIGQQ IPGQLYAAVA EVLAWVWQLK
360 370 380
RWRLAGGQRP VQPTHLPVPE ALDFINEKPT HE
Length:382
Mass (Da):42,238
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E319DFC30FEC4CC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti250A → R in AAC17834 (Ref. 1) Curated1
Sequence conflicti316P → R in AAC17834 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U88319 Genomic DNA Translation: AAC17834.1
U00096 Genomic DNA Translation: AAC74950.1
AP009048 Genomic DNA Translation: BAA15696.1

Protein sequence database of the Protein Information Resource

More...
PIRi
H64950

NCBI Reference Sequences

More...
RefSeqi
NP_416394.1, NC_000913.3
WP_001278954.1, NZ_STEB01000026.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC74950; AAC74950; b1880
BAA15696; BAA15696; BAA15696

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
946391

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW1869
eco:b1880

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.368

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88319 Genomic DNA Translation: AAC17834.1
U00096 Genomic DNA Translation: AAC74950.1
AP009048 Genomic DNA Translation: BAA15696.1
PIRiH64950
RefSeqiNP_416394.1, NC_000913.3
WP_001278954.1, NZ_STEB01000026.1

3D structure databases

SMRiP76299
ModBaseiSearch...

Protein-protein interaction databases

BioGridi4260378, 21 interactors
IntActiP76299, 3 interactors
STRINGi511145.b1880

Protein family/group databases

MEROPSiN06.A01

Proteomic databases

PaxDbiP76299
PRIDEiP76299

Genome annotation databases

EnsemblBacteriaiAAC74950; AAC74950; b1880
BAA15696; BAA15696; BAA15696
GeneIDi946391
KEGGiecj:JW1869
eco:b1880
PATRICifig|1411691.4.peg.368

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB3789

Phylogenomic databases

eggNOGiENOG4105D00 Bacteria
COG1377 LUCA
HOGENOMiHOG000253899
InParanoidiP76299
KOiK02401
PhylomeDBiP76299

Enzyme and pathway databases

BioCyciEcoCyc:G7028-MONOMER
ECOL316407:JW1869-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P76299

Family and domain databases

Gene3Di3.40.1690.10, 1 hit
InterProiView protein in InterPro
IPR006136 FlhB
IPR006135 T3SS_substrate_exporter
IPR029025 T3SS_substrate_exporter_C
PANTHERiPTHR30531 PTHR30531, 1 hit
PfamiView protein in Pfam
PF01312 Bac_export_2, 1 hit
PRINTSiPR00950 TYPE3IMSPROT
SUPFAMiSSF160544 SSF160544, 1 hit
TIGRFAMsiTIGR00328 flhB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFLHB_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P76299
Secondary accession number(s): O87955
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 13, 2019
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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