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Entry version 136 (07 Oct 2020)
Sequence version 2 (01 Dec 2000)
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Protein

Intermembrane transport protein YebT

Gene

yebT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a transport pathway that contributes to membrane integrity (PubMed:27795327). May directly span the intermembrane space, facilitating the transport of substrates across the periplasm (Probable).1 Publication1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:G7007-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.69.1.2, the intermembrane phospholipid translocase (impl-t) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Intermembrane transport protein YebTCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:yebT
Ordered Locus Names:b1834, JW1823
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 19Cytoplasmic1 PublicationAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 877Periplasmic1 PublicationAdd BLAST837

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001690551 – 877Intermembrane transport protein YebTAdd BLAST877

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P76272

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P76272

PRoteomics IDEntifications database

More...
PRIDEi
P76272

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by a defect in lipopolysaccharide molecules.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homohexamer (PubMed:28388411). May form a complex with YebS (Probable).

1 Publication1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4259157, 10 interactors
850709, 1 interactor

Database of interacting proteins

More...
DIPi
DIP-11815N

Protein interaction database and analysis system

More...
IntActi
P76272, 6 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b1834

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1877
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P76272

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni46 – 137MCE/MlaD 1CuratedAdd BLAST92
Regioni163 – 220MCE/MlaD 2CuratedAdd BLAST58
Regioni280 – 351MCE/MlaD 3CuratedAdd BLAST72
Regioni394 – 455MCE/MlaD 4CuratedAdd BLAST62
Regioni636 – 724MCE/MlaD 5CuratedAdd BLAST89
Regioni747 – 810MCE/MlaD 6CuratedAdd BLAST64

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PqiB family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG3008, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015836_0_0_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P76272

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003399, Mce/MlaD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02470, MlaD, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P76272-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQETPASTT EAQIKNKRRI SPFWLLPFIA LMIASWLIWD SYQDRGNTVT
60 70 80 90 100
IDFMSADGIV PGRTPVRYQG VEVGTVQDIS LSDDLRKIEV KVSIKSDMKD
110 120 130 140 150
ALREETQFWL VTPKASLAGV SGLDALVGGN YIGMMPGKGK EQDHFVALDT
160 170 180 190 200
QPKYRLDNGD LMIHLQAPDL GSLNSGSLVY FRKIPVGKVY DYAINPNKQG
210 220 230 240 250
VVIDVLIERR FTDLVKKGSR FWNVSGVDAN VSISGAKVKL ESLAALVNGA
260 270 280 290 300
IAFDSPEESK PAEAEDTFGL YEDLAHSQRG VIIKLELPSG AGLTADSTPL
310 320 330 340 350
MYQGLEVGQL TKLDLNPGGK VTGEMTVDPS VVTLLRENTR IELRNPKLSL
360 370 380 390 400
SDANLSALLT GKTFELVPGD GEPRKEFVVV PGEKALLHEP DVLTLTLTAP
410 420 430 440 450
ESYGIDAGQP LILHGVQVGQ VIDRKLTSKG VTFTVAIEPQ HRELVKGDSK
460 470 480 490 500
FVVNSRVDVK VGLDGVEFLG ASASEWINGG IRILPGDKGE MKASYPLYAN
510 520 530 540 550
LEKALENSLS DLPTTTVSLS AETLPDVQAG SVVLYRKFEV GEVITVRPRA
560 570 580 590 600
NAFDIDLHIK PEYRNLLTSN SVFWAEGGAK VQLNGSGLTV QASPLSRALK
610 620 630 640 650
GAISFDNLSG ASASQRKGDK RILYASETAA RAVGGQITLH AFDAGKLAVG
660 670 680 690 700
MPIRYLGIDI GQIQTLDLIT ARNEVQAKAV LYPEYVQTFA RGGTRFSVVT
710 720 730 740 750
PQISAAGVEH LDTILQPYIN VEPGRGNPRR DFELQEATIT DSRYLDGLSI
760 770 780 790 800
IVEAPEAGSL GIGTPVLFRG LEVGTVTGMT LGTLSDRVMI AMRISKRYQH
810 820 830 840 850
LVRNNSVFWL ASGYSLDFGL TGGVVKTGTF NQFIRGGIAF ATPPGTPLAP
860 870
KAQEGKHFLL QESEPKEWRE WGTALPK
Length:877
Mass (Da):94,970
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F4585F094D2D05A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74904.2
AP009048 Genomic DNA Translation: BAA15647.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B64945

NCBI Reference Sequences

More...
RefSeqi
NP_416348.2, NC_000913.3
WP_001326728.1, NZ_SSZK01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC74904; AAC74904; b1834
BAA15647; BAA15647; BAA15647

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
946352

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW1823
eco:b1834

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|511145.12.peg.1912

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74904.2
AP009048 Genomic DNA Translation: BAA15647.1
PIRiB64945
RefSeqiNP_416348.2, NC_000913.3
WP_001326728.1, NZ_SSZK01000001.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6KZ3electron microscopy3.10A/B/C/D/E/F46-509[»]
6KZ4electron microscopy3.00A/B/C/D/E/F512-877[»]
6V0Celectron microscopy3.46A/B/C/D/E/F46-877[»]
6V0Delectron microscopy3.49A/B/C/D/E/F46-877[»]
6V0Eelectron microscopy3.06A/B/C/D/E/F46-877[»]
6V0Felectron microscopy2.96A/B/C/D/E/F46-877[»]
6V0Gelectron microscopy3.03A/B/C/D/E/F46-877[»]
6V0Helectron microscopy3.60A/B/C/D/E/F46-877[»]
6V0Ielectron microscopy3.43A/B/C/D/E/F46-877[»]
6V0Jelectron microscopy3.78A/B/C/D/E/F46-877[»]
6VCIX-ray2.15A/C159-383[»]
SMRiP76272
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi4259157, 10 interactors
850709, 1 interactor
DIPiDIP-11815N
IntActiP76272, 6 interactors
STRINGi511145.b1834

Protein family/group databases

TCDBi9.A.69.1.2, the intermembrane phospholipid translocase (impl-t) family

Proteomic databases

jPOSTiP76272
PaxDbiP76272
PRIDEiP76272

Genome annotation databases

EnsemblBacteriaiAAC74904; AAC74904; b1834
BAA15647; BAA15647; BAA15647
GeneIDi946352
KEGGiecj:JW1823
eco:b1834
PATRICifig|511145.12.peg.1912

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB3776

Phylogenomic databases

eggNOGiCOG3008, Bacteria
HOGENOMiCLU_015836_0_0_6
InParanoidiP76272

Enzyme and pathway databases

BioCyciEcoCyc:G7007-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P76272

Family and domain databases

InterProiView protein in InterPro
IPR003399, Mce/MlaD
PfamiView protein in Pfam
PF02470, MlaD, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYEBT_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P76272
Secondary accession number(s): P97190, P97191
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 7, 2020
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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