UniProtKB - P76250 (DMLR_ECOLI)
Protein
HTH-type transcriptional regulator DmlR
Gene
dmlR
Organism
Escherichia coli (strain K12)
Status
Functioni
Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression.2 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 22 – 41 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: UniProtKB
- sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- malate metabolic process Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:G6985-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: HTH-type transcriptional regulator DmlRAlternative name(s): D-malate degradation protein R |
Gene namesi | Name:dmlR Synonyms:yeaT Ordered Locus Names:b1799, JW1788 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Deletion of dmlR inhibits aerobic growth on D-malate and inhibits the induction of dmlA expression by D-malate and L- and meso-tartrate.2 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000105786 | 1 – 307 | HTH-type transcriptional regulator DmlRAdd BLAST | 307 |
Proteomic databases
jPOSTi | P76250 |
PaxDbi | P76250 |
PRIDEi | P76250 |
Expressioni
Inductioni
Expression of dmlR is subject to negative autoregulation under both aerobic and anaerobic growth conditions. Its level of expression is generally lower under anaerobic conditions than that under aerobic conditions.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260334, 12 interactors |
IntActi | P76250, 13 interactors |
STRINGi | 511145.b1799 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 62 | HTH lysR-typePROSITE-ProRule annotationAdd BLAST | 58 |
Sequence similaritiesi
Belongs to the LysR transcriptional regulatory family.Curated
Phylogenomic databases
eggNOGi | COG0583, Bacteria |
HOGENOMi | CLU_039613_16_4_6 |
InParanoidi | P76250 |
PhylomeDBi | P76250 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR005119, LysR_subst-bd IPR000847, Tscrpt_reg_HTH_LysR IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00126, HTH_1, 1 hit PF03466, LysR_substrate, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50931, HTH_LYSR, 1 hit |
i Sequence
Sequence statusi: Complete.
P76250-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNNLPLLNDL RVFMLVARRA GFAAVAEELG VSPAFVSKRI ALLEQTLNVV
60 70 80 90 100
LLHRTTRRVT ITEEGERIYE WAQRILQDVG QMMDELSDVR QVPQGMLRII
110 120 130 140 150
SSFGFGRQVV APALLALAKA YPQLELRFDV EDRLVDLVNE GVDLDIRIGD
160 170 180 190 200
DIAPNLIARK LATNYRILCA SPEFIAQHGA PKHLTDLSAL PCLVIKERDH
210 220 230 240 250
PFGVWQLRNK EGPHAIKVTG PLSSNHGEIV HQWCLDGQGI ALRSWWDVSE
260 270 280 290 300
NIASGHLVQV LPEYYQPANV WAVYVSRLAT SAKVRITVEF LRQYFAEHYP
NFSLEHA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74869.2 AP009048 Genomic DNA Translation: BAA15594.1 |
PIRi | G64940 |
RefSeqi | NP_416313.4, NC_000913.3 WP_001061575.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC74869; AAC74869; b1799 BAA15594; BAA15594; BAA15594 |
GeneIDi | 946316 |
KEGGi | ecj:JW1788 eco:b1799 |
PATRICi | fig|1411691.4.peg.454 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74869.2 AP009048 Genomic DNA Translation: BAA15594.1 |
PIRi | G64940 |
RefSeqi | NP_416313.4, NC_000913.3 WP_001061575.1, NZ_LN832404.1 |
3D structure databases
SMRi | P76250 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260334, 12 interactors |
IntActi | P76250, 13 interactors |
STRINGi | 511145.b1799 |
Proteomic databases
jPOSTi | P76250 |
PaxDbi | P76250 |
PRIDEi | P76250 |
Genome annotation databases
EnsemblBacteriai | AAC74869; AAC74869; b1799 BAA15594; BAA15594; BAA15594 |
GeneIDi | 946316 |
KEGGi | ecj:JW1788 eco:b1799 |
PATRICi | fig|1411691.4.peg.454 |
Organism-specific databases
EchoBASEi | EB3279 |
Phylogenomic databases
eggNOGi | COG0583, Bacteria |
HOGENOMi | CLU_039613_16_4_6 |
InParanoidi | P76250 |
PhylomeDBi | P76250 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6985-MONOMER |
Miscellaneous databases
PROi | PR:P76250 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR005119, LysR_subst-bd IPR000847, Tscrpt_reg_HTH_LysR IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00126, HTH_1, 1 hit PF03466, LysR_substrate, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50931, HTH_LYSR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DMLR_ECOLI | |
Accessioni | P76250Primary (citable) accession number: P76250 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | December 15, 1998 | |
Last modified: | December 2, 2020 | |
This is version 133 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families