UniProtKB - P76241 (NIMR_ECOLI)
Protein
HTH-type transcriptional regulator NimR
Gene
nimR
Organism
Escherichia coli (strain K12)
Status
Functioni
Negatively regulates expression of the nimT operon and its own expression. Acts by binding to the nimR-nimT intergenic region.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 178 – 199 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 22 | |
DNA bindingi | 225 – 248 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA binding Source: EcoCyc
- DNA-binding transcription factor activity Source: InterPro
- sequence-specific DNA binding Source: InterPro
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: EcoCyc
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:G6976-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: HTH-type transcriptional regulator NimRCuratedAlternative name(s): Regulator of nimT1 Publication |
Gene namesi | Name:nimR1 Publication Synonyms:yeaM Ordered Locus Names:b1790, JW1779 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000194611 | 1 – 273 | HTH-type transcriptional regulator NimRAdd BLAST | 273 |
Proteomic databases
PaxDbi | P76241 |
PRIDEi | P76241 |
Expressioni
Inductioni
Negatively autoregulated.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260327, 11 interactors |
IntActi | P76241, 15 interactors |
STRINGi | 511145.b1790 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 158 – 258 | HTH araC/xylS-typePROSITE-ProRule annotationAdd BLAST | 101 |
Phylogenomic databases
eggNOGi | COG2207, Bacteria |
HOGENOMi | CLU_000445_87_0_6 |
InParanoidi | P76241 |
PhylomeDBi | P76241 |
Family and domain databases
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR003313, AraC-bd IPR009057, Homeobox-like_sf IPR018060, HTH_AraC IPR018062, HTH_AraC-typ_CS IPR014710, RmlC-like_jellyroll IPR011051, RmlC_Cupin_sf |
Pfami | View protein in Pfam PF02311, AraC_binding, 1 hit PF12833, HTH_18, 1 hit |
SMARTi | View protein in SMART SM00342, HTH_ARAC, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF51182, SSF51182, 1 hit |
PROSITEi | View protein in PROSITE PS00041, HTH_ARAC_FAMILY_1, 1 hit PS01124, HTH_ARAC_FAMILY_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P76241-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMHRLNLNGY EPDRHHEAAV AFCIHAGTDE LTSPVHQHRK GQLILALHGA
60 70 80 90 100
ITCTVENALW MVPPQYAVWI PGGVEHSNQV TANAELCFLF IEPSAVTMPT
110 120 130 140 150
TCCTLKISPL CRELILTLAN RTTTQRAEPM TRRLIQVLFD ELPQQPQQQL
160 170 180 190 200
HLPVSSHPKI RTMVEMMAKG PVEWGALGQW AGFFAMSERN LARLIVKETG
210 220 230 240 250
LSFRQWRQQL QLIMALQGLV KGDTVQKVAH TLGYDSTTAF ITMFKKGLGQ
260 270
TPGRYIARLT TVSPQSAKPD PRQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74860.1 AP009048 Genomic DNA Translation: BAE76528.1 |
PIRi | F64939 |
RefSeqi | NP_416304.1, NC_000913.3 WP_000972248.1, NZ_SSZK01000001.1 |
Genome annotation databases
EnsemblBacteriai | AAC74860; AAC74860; b1790 BAE76528; BAE76528; BAE76528 |
GeneIDi | 57731185 946590 |
KEGGi | ecj:JW1779 eco:b1790 |
PATRICi | fig|511145.12.peg.1864 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74860.1 AP009048 Genomic DNA Translation: BAE76528.1 |
PIRi | F64939 |
RefSeqi | NP_416304.1, NC_000913.3 WP_000972248.1, NZ_SSZK01000001.1 |
3D structure databases
SMRi | P76241 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260327, 11 interactors |
IntActi | P76241, 15 interactors |
STRINGi | 511145.b1790 |
Proteomic databases
PaxDbi | P76241 |
PRIDEi | P76241 |
Genome annotation databases
EnsemblBacteriai | AAC74860; AAC74860; b1790 BAE76528; BAE76528; BAE76528 |
GeneIDi | 57731185 946590 |
KEGGi | ecj:JW1779 eco:b1790 |
PATRICi | fig|511145.12.peg.1864 |
Organism-specific databases
EchoBASEi | EB3272 |
Phylogenomic databases
eggNOGi | COG2207, Bacteria |
HOGENOMi | CLU_000445_87_0_6 |
InParanoidi | P76241 |
PhylomeDBi | P76241 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6976-MONOMER |
Miscellaneous databases
PROi | PR:P76241 |
Family and domain databases
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR003313, AraC-bd IPR009057, Homeobox-like_sf IPR018060, HTH_AraC IPR018062, HTH_AraC-typ_CS IPR014710, RmlC-like_jellyroll IPR011051, RmlC_Cupin_sf |
Pfami | View protein in Pfam PF02311, AraC_binding, 1 hit PF12833, HTH_18, 1 hit |
SMARTi | View protein in SMART SM00342, HTH_ARAC, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF51182, SSF51182, 1 hit |
PROSITEi | View protein in PROSITE PS00041, HTH_ARAC_FAMILY_1, 1 hit PS01124, HTH_ARAC_FAMILY_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NIMR_ECOLI | |
Accessioni | P76241Primary (citable) accession number: P76241 Secondary accession number(s): Q2MB28 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | February 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |