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Protein

Voltage-gated ClC-type chloride channel ClcB

Gene

clcB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChloride channel, Ion channel, Voltage-gated channel
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

BioCyciEcoCyc:YNFJ-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-gated ClC-type chloride channel ClcB
Gene namesi
Name:clcB
Synonyms:mriT, ynfJ
Ordered Locus Names:b1592, JW5263
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13848 clcB

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1CytoplasmicSequence analysis1
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Topological domaini23 – 53PeriplasmicSequence analysisAdd BLAST31
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Topological domaini75 – 145CytoplasmicSequence analysisAdd BLAST71
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 177PeriplasmicSequence analysisAdd BLAST11
Transmembranei178 – 200HelicalSequence analysisAdd BLAST23
Topological domaini201 – 221CytoplasmicSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 257PeriplasmicSequence analysisAdd BLAST15
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 290CytoplasmicSequence analysisAdd BLAST12
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Topological domaini312 – 315PeriplasmicSequence analysis4
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Topological domaini337 – 351CytoplasmicSequence analysisAdd BLAST15
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Topological domaini373 – 379PeriplasmicSequence analysis7
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Topological domaini401 – 418CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

  • chloride channel complex Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000944851 – 418Voltage-gated ClC-type chloride channel ClcBAdd BLAST418

Proteomic databases

PaxDbiP76175
PRIDEiP76175

Interactioni

Protein-protein interaction databases

BioGridi4259118, 8 interactors
DIPiDIP-28065N
IntActiP76175, 1 interactor
STRINGi316385.ECDH10B_1725

Structurei

3D structure databases

ProteinModelPortaliP76175
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CMQ Bacteria
COG0038 LUCA
HOGENOMiHOG000230177
InParanoidiP76175
KOiK03281
OMAiGPLTMTF
PhylomeDBiP76175

Family and domain databases

Gene3Di1.10.3080.10, 1 hit
HAMAPiMF_01203 CLC_ClcB, 1 hit
InterProiView protein in InterPro
IPR014743 Cl-channel_core
IPR001807 Cl-channel_volt-gated
IPR023790 Cl-channel_volt-gated_ClcB
PfamiView protein in Pfam
PF00654 Voltage_CLC, 1 hit
PRINTSiPR00762 CLCHANNEL
SUPFAMiSSF81340 SSF81340, 1 hit

Sequencei

Sequence statusi: Complete.

P76175-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHRLLIATV VGILAAFAVA GFRHAMLLLE WLFLNNDSGS LVNAATNLSP
60 70 80 90 100
WRRLLTPALG GLAAGLLLMG WQKFTQQRPH APTDYMEALQ TDGQFDYAAS
110 120 130 140 150
LVKSLASLLV VTSGSAIGRE GAMILLAALA ASCFAQRFTP RQEWKLWIAC
160 170 180 190 200
GAAAGMAAAY RAPLAGSLFI AEVLFGTMML ASLGPVIISA VVALLVSNLI
210 220 230 240 250
NHSDALLYNV QLSVTVQARD YALIISTGVL AGLCGPLLLT LMNACHRGFV
260 270 280 290 300
SLKLAPPWQL ALGGLIVGLL SLFTPAVWGN GYSTVQSFLT APPLLMIIAG
310 320 330 340 350
IFLCKLCAVL ASSGSGAPGG VFTPTLFIGL AIGMLYGRSL GLWFPDGEEI
360 370 380 390 400
TLLLGLTGMA TLLAATTHAP IMSTLMICEM TGEYQLLPGL LIACVIASVI
410
SRTLHRDSIY RQHTAQHS
Length:418
Mass (Da):44,153
Last modified:April 23, 2003 - v2
Checksum:iF19EAFD7C87F4C01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74664.2
AP009048 Genomic DNA Translation: BAA15316.2
PIRiB64915
RefSeqiNP_416109.2, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAC74664; AAC74664; b1592
BAA15316; BAA15316; BAA15316
GeneIDi947179
KEGGiecj:JW5263
eco:b1592
PATRICifig|1411691.4.peg.670

Similar proteinsi

Entry informationi

Entry nameiCLCB_ECOLI
AccessioniPrimary (citable) accession number: P76175
Secondary accession number(s): P77195
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: April 23, 2003
Last modified: April 25, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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