UniProtKB - P76086 (PAAX_ECOLI)
Protein
Transcriptional repressor PaaX
Gene
paaX
Organism
Escherichia coli (strain K12)
Status
Functioni
Negative regulator of the paaZ and paaABCDEFGHIJK catabolic operons. Binds the consensus sequence 5'-WWTRTGATTCGYGWT-3'. Binding of PaaX is specifically inhibited by phenylacetyl-coenzyme A (PA-CoA).2 Publications
: phenylacetate degradation Pathwayi
This protein is involved in the pathway phenylacetate degradation, which is part of Aromatic compound metabolism.View all proteins of this organism that are known to be involved in the pathway phenylacetate degradation and in Aromatic compound metabolism.
GO - Molecular functioni
- bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding Source: EcoCyc
GO - Biological processi
- negative regulation of DNA-templated transcription, initiation Source: EcoCyc
- phenylacetate catabolic process Source: UniProtKB
- transcription, DNA-templated Source: EcoCyc
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:G6720-MONOMER |
UniPathwayi | UPA00930 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcriptional repressor PaaX |
Gene namesi | Name:paaX Synonyms:ydbY Ordered Locus Names:b1399, JW1394 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058165 | 1 – 316 | Transcriptional repressor PaaXAdd BLAST | 316 |
Proteomic databases
jPOSTi | P76086 |
PaxDbi | P76086 |
PRIDEi | P76086 |
Interactioni
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 4263014, 16 interactors 850329, 6 interactors |
DIPi | DIP-10431N |
IntActi | P76086, 21 interactors |
STRINGi | 511145.b1399 |
Family & Domainsi
Sequence similaritiesi
Belongs to the PaaX family.Curated
Phylogenomic databases
eggNOGi | COG3327, Bacteria |
HOGENOMi | CLU_067515_0_0_6 |
InParanoidi | P76086 |
PhylomeDBi | P76086 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR012906, PaaX-like_N IPR013225, PaaX_C IPR011965, PaaX_trns_reg IPR036388, WH-like_DNA-bd_sf |
Pfami | View protein in Pfam PF07848, PaaX, 1 hit PF08223, PaaX_C, 1 hit |
PIRSFi | PIRSF020623, PaaX, 1 hit |
TIGRFAMsi | TIGR02277, PaaX_trns_reg, 1 hit |
i Sequence
Sequence statusi: Complete.
P76086-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKLDTFIQH AVNAVPVSGT SLISSLYGDS LSHRGGEIWL GSLAALLEGL
60 70 80 90 100
GFGERFVRTA LFRLNKEGWL DVSRIGRRSF YSLSDKGLRL TRRAESKIYR
110 120 130 140 150
AEQPAWDGKW LLLLSEGLDK STLADVKKQL IWQGFGALAP SLMASPSQKL
160 170 180 190 200
ADVQTLLHEA GVADNVICFE AQIPLALSRA ALRARVEECW HLTEQNAMYE
210 220 230 240 250
TFIQSFRPLV PLLKEAADEL TPERAFHIQL LLIHFYRRVV LKDPLLPEEL
260 270 280 290 300
LPAHWAGHTA RQLCINIYQR VAPAALAFVS EKGETSVGEL PAPGSLYFQR
310
FGGLNIEQEA LCQFIR
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 5 | D → V in strain: W. | 1 | |
Natural varianti | 311 | L → I in strain: W. | 1 | |
Natural varianti | 315 | I → T in strain: W. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97452 Genomic DNA Translation: CAA66101.1 U00096 Genomic DNA Translation: AAC74481.1 AP009048 Genomic DNA Translation: BAE76429.1 |
PIRi | B64891 |
RefSeqi | NP_415917.1, NC_000913.3 WP_000039887.1, NZ_SSZK01000012.1 |
Genome annotation databases
EnsemblBacteriai | AAC74481; AAC74481; b1399 BAE76429; BAE76429; BAE76429 |
GeneIDi | 945966 |
KEGGi | ecj:JW1394 eco:b1399 |
PATRICi | fig|1411691.4.peg.872 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97452 Genomic DNA Translation: CAA66101.1 U00096 Genomic DNA Translation: AAC74481.1 AP009048 Genomic DNA Translation: BAE76429.1 |
PIRi | B64891 |
RefSeqi | NP_415917.1, NC_000913.3 WP_000039887.1, NZ_SSZK01000012.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4263014, 16 interactors 850329, 6 interactors |
DIPi | DIP-10431N |
IntActi | P76086, 21 interactors |
STRINGi | 511145.b1399 |
Proteomic databases
jPOSTi | P76086 |
PaxDbi | P76086 |
PRIDEi | P76086 |
Genome annotation databases
EnsemblBacteriai | AAC74481; AAC74481; b1399 BAE76429; BAE76429; BAE76429 |
GeneIDi | 945966 |
KEGGi | ecj:JW1394 eco:b1399 |
PATRICi | fig|1411691.4.peg.872 |
Organism-specific databases
EchoBASEi | EB3509 |
Phylogenomic databases
eggNOGi | COG3327, Bacteria |
HOGENOMi | CLU_067515_0_0_6 |
InParanoidi | P76086 |
PhylomeDBi | P76086 |
Enzyme and pathway databases
UniPathwayi | UPA00930 |
BioCyci | EcoCyc:G6720-MONOMER |
Miscellaneous databases
PROi | PR:P76086 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR012906, PaaX-like_N IPR013225, PaaX_C IPR011965, PaaX_trns_reg IPR036388, WH-like_DNA-bd_sf |
Pfami | View protein in Pfam PF07848, PaaX, 1 hit PF08223, PaaX_C, 1 hit |
PIRSFi | PIRSF020623, PaaX, 1 hit |
TIGRFAMsi | TIGR02277, PaaX_trns_reg, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PAAX_ECOLI | |
Accessioni | P76086Primary (citable) accession number: P76086 Secondary accession number(s): O53019, Q2MBC7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | February 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families