UniProtKB - P76079 (PAAC_ECOLI)
Protein
1,2-phenylacetyl-CoA epoxidase, subunit C
Gene
paaC
Organism
Escherichia coli (strain K12)
Status
Functioni
Component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA (PA-CoA) to form 1,2-epoxyphenylacetyl-CoA. The subunit C may be essential for structural integrity of the alpha subunit.3 Publications
: phenylacetate degradation Pathwayi
This protein is involved in the pathway phenylacetate degradation, which is part of Aromatic compound metabolism.View all proteins of this organism that are known to be involved in the pathway phenylacetate degradation and in Aromatic compound metabolism.
GO - Biological processi
- phenylacetate catabolic process Source: UniProtKB
Enzyme and pathway databases
BioCyci | EcoCyc:G6711-MONOMER ECOL316407:JW1385-MONOMER MetaCyc:G6711-MONOMER |
BRENDAi | 1.14.13.149 2026 |
UniPathwayi | UPA00930 |
Names & Taxonomyi
Protein namesi | Recommended name: 1,2-phenylacetyl-CoA epoxidase, subunit CAlternative name(s): 1,2-phenylacetyl-CoA epoxidase, structural subunit beta 1,2-phenylacetyl-CoA monooxygenase, subunit C |
Gene namesi | Name:paaC Synonyms:ydbP Ordered Locus Names:b1390, JW1385 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058161 | 1 – 248 | 1,2-phenylacetyl-CoA epoxidase, subunit CAdd BLAST | 248 |
Proteomic databases
PaxDbi | P76079 |
PRIDEi | P76079 |
Expressioni
Inductioni
Activated by cAMP receptor protein (CRP), integration host factor (IHF) and by phenylacetyl-coenzyme A (PA-CoA) that prevents PaaX from binding its target sequences. Inhibited by PaaX.2 Publications
Interactioni
Subunit structurei
Forms a stable heterotetramer (dimer of heterodimers) with PaaA and a stable heterodimer with PaaB.
3 PublicationsBinary interactionsi
Protein-protein interaction databases
BioGridi | 4260175, 102 interactors 850320, 5 interactors |
ComplexPortali | CPX-2844 paaABCE phenylacetyl-CoA monooxygenase complex |
IntActi | P76079, 9 interactors |
STRINGi | 511145.b1390 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P76079 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P76079 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 76 – 79 | Substrate bindingBy similarity | 4 | |
Regioni | 177 – 179 | Substrate bindingBy similarity | 3 |
Phylogenomic databases
eggNOGi | ENOG4105D9S Bacteria COG3396 LUCA |
HOGENOMi | HOG000254959 |
InParanoidi | P76079 |
KOi | K02611 |
PhylomeDBi | P76079 |
Family and domain databases
Gene3Di | 1.20.1260.10, 1 hit |
InterProi | View protein in InterPro IPR012347 Ferritin-like IPR009078 Ferritin-like_SF IPR007814 PaaA_PaaC IPR011882 PaaC |
Pfami | View protein in Pfam PF05138 PaaA_PaaC, 1 hit |
PIRSFi | PIRSF037834 PA_CoA_Oase3, 1 hit |
SUPFAMi | SSF47240 SSF47240, 1 hit |
TIGRFAMsi | TIGR02158 PA_CoA_Oxy3, 1 hit |
i Sequence
Sequence statusi: Complete.
P76079-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNQLTAYTLR LGDNCLVLSQ RLGEWCGHAP ELEIDLALAN IGLDLLGQAR
60 70 80 90 100
NFLSYAAELA GEGDEDTLAF TRDERQFSNL LLVEQPNGNF ADTIARQYFI
110 120 130 140 150
DAWHVALFTR LMESRDPQLA AISAKAIKEA RYHLRFSRGW LERLGNGTDV
160 170 180 190 200
SGQKMQQAIN KLWRFTAELF DADEIDIALS EEGIAVDPRT LRAAWEAEVF
210 220 230 240
AGINEATLNV PQEQAYRTGG KKGLHTEHLG PMLAEMQYLQ RVLPGQQW
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 160 | N → D in strain: W. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97452 Genomic DNA Translation: CAA66092.1 U00096 Genomic DNA Translation: AAC74472.1 AP009048 Genomic DNA Translation: BAE76425.1 |
PIRi | A64890 |
RefSeqi | NP_415908.1, NC_000913.3 WP_001072837.1, NZ_STEB01000005.1 |
Genome annotation databases
EnsemblBacteriai | AAC74472; AAC74472; b1390 BAE76425; BAE76425; BAE76425 |
GeneIDi | 945956 |
KEGGi | ecj:JW1385 eco:b1390 |
PATRICi | fig|1411691.4.peg.881 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97452 Genomic DNA Translation: CAA66092.1 U00096 Genomic DNA Translation: AAC74472.1 AP009048 Genomic DNA Translation: BAE76425.1 |
PIRi | A64890 |
RefSeqi | NP_415908.1, NC_000913.3 WP_001072837.1, NZ_STEB01000005.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1OTK | X-ray | 2.00 | A/B | 2-248 | [»] | |
3PVR | X-ray | 2.10 | B/C | 2-248 | [»] | |
3PVT | X-ray | 2.03 | B/C | 2-248 | [»] | |
3PVY | X-ray | 2.15 | B/C | 2-248 | [»] | |
3PW1 | X-ray | 2.25 | B/C | 2-248 | [»] | |
3PW8 | X-ray | 2.97 | A/B | 2-248 | [»] | |
3PWQ | X-ray | 2.65 | A/B/E/G/I/J/K/R | 2-248 | [»] | |
4II4 | X-ray | 2.80 | B/C | 2-248 | [»] | |
SMRi | P76079 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 4260175, 102 interactors 850320, 5 interactors |
ComplexPortali | CPX-2844 paaABCE phenylacetyl-CoA monooxygenase complex |
IntActi | P76079, 9 interactors |
STRINGi | 511145.b1390 |
Proteomic databases
PaxDbi | P76079 |
PRIDEi | P76079 |
Genome annotation databases
EnsemblBacteriai | AAC74472; AAC74472; b1390 BAE76425; BAE76425; BAE76425 |
GeneIDi | 945956 |
KEGGi | ecj:JW1385 eco:b1390 |
PATRICi | fig|1411691.4.peg.881 |
Organism-specific databases
EchoBASEi | EB3500 |
Phylogenomic databases
eggNOGi | ENOG4105D9S Bacteria COG3396 LUCA |
HOGENOMi | HOG000254959 |
InParanoidi | P76079 |
KOi | K02611 |
PhylomeDBi | P76079 |
Enzyme and pathway databases
UniPathwayi | UPA00930 |
BioCyci | EcoCyc:G6711-MONOMER ECOL316407:JW1385-MONOMER MetaCyc:G6711-MONOMER |
BRENDAi | 1.14.13.149 2026 |
Miscellaneous databases
EvolutionaryTracei | P76079 |
PROi | PR:P76079 |
Family and domain databases
Gene3Di | 1.20.1260.10, 1 hit |
InterProi | View protein in InterPro IPR012347 Ferritin-like IPR009078 Ferritin-like_SF IPR007814 PaaA_PaaC IPR011882 PaaC |
Pfami | View protein in Pfam PF05138 PaaA_PaaC, 1 hit |
PIRSFi | PIRSF037834 PA_CoA_Oase3, 1 hit |
SUPFAMi | SSF47240 SSF47240, 1 hit |
TIGRFAMsi | TIGR02158 PA_CoA_Oxy3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PAAC_ECOLI | |
Accessioni | P76079Primary (citable) accession number: P76079 Secondary accession number(s): O53011, Q2MBD1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | February 1, 1997 | |
Last modified: | November 13, 2019 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references