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Entry version 138 (13 Nov 2019)
Sequence version 2 (15 Jul 1998)
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Protein

Glucosylglycerate phosphorylase

Gene

ycjM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reversible phosphorolysis of glucosylglycerate into alpha-D-glucose 1-phosphate (Glc1P) and D-glycerate (also called (R)-glycerate) (PubMed:28754708, PubMed:29684280). May be a regulator of intracellular levels of glucosylglycerate, a compatible solute that primarily protects organisms facing salt stress and very specific nutritional constraints (PubMed:28754708). Cannot catalyze the phosphorolysis of sucrose (PubMed:28754708). Does not act on other sugars such as alpha-D-galactose 1-phosphate, alpha-D-mannose 1-phosphate or beta-D-glucose 1-phosphate; in vitro D-erythronate can substitue for D-glycerate with a much lower efficiency (PubMed:29684280).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 2.2 sec(-1) for phosphorolysis of 2-O-(alpha-D-glucopyranosyl)-D-glycerate, kcat is 325 sec(-1) for glyceration of alpha-D-glucose 1-phosphate.1 Publication
  1. KM=3.4 mM for D-glycerate (at pH 6.5 and 30 degrees Celsius)1 Publication
  2. KM=69 µM for 2-O-(alpha-D-glucopyranosyl)-D-glycerate (at pH 6.5 and 30 degrees Celsius)1 Publication
  3. KM=2.2 mM for phosphate (at pH 6.5 and 30 degrees Celsius)1 Publication
  4. KM=9.4 mM for alpha-D-glucose 1-phosphate (at pH 6.5 and 30 degrees Celsius)1 Publication
  5. KM=4.4 mM for D-glycerate (at pH 6.5 and 30 degrees Celsius)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei229NucleophileBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionGlycosyltransferase, Transferase
    Biological processCarbohydrate metabolism

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    EcoCyc:G6647-MONOMER
    ECOL316407:JW1302-MONOMER
    MetaCyc:G6647-MONOMER

    Protein family/group databases

    Carbohydrate-Active enZymes

    More...
    CAZyi
    GH13 Glycoside Hydrolase Family 13

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Glucosylglycerate phosphorylase1 Publication (EC:2.4.1.3522 Publications)
    Short name:
    GGa phosphorylase1 Publication
    Short name:
    GGaP1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ycjM
    Synonyms:ggaP
    Ordered Locus Names:b1309, JW1302
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    No visible phenotype when grown on glucose.1 Publication

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000722991 – 559Glucosylglycerate phosphorylaseAdd BLAST559

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P76041

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P76041

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P76041

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    4263230, 11 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P76041, 2 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    511145.b1309

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG4107QW3 Bacteria
    COG0366 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000089743

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P76041

    KEGG Orthology (KO)

    More...
    KOi
    K22597

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P76041

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd11356 AmyAc_Sucrose_phosphorylase-like_1, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR033746 GGa_phosphorylase
    IPR006047 Glyco_hydro_13_cat_dom
    IPR017853 Glycoside_hydrolase_SF
    IPR016377 Sucrose_GGa_phosphorylase-rel

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00128 Alpha-amylase, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF003059 Sucrose_phosphorylase, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00642 Aamy, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51445 SSF51445, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P76041-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MKQKITDYLD EIYGGTFTAT HLQKLVTRLE SAKRLITQRR KKHWDESDVV
    60 70 80 90 100
    LITYADQFHS NDLKPLPTFN QFYHQWLQSI FSHVHLLPFY PWSSDDGFSV
    110 120 130 140 150
    IDYHQVASEA GEWQDIQQLG ECSHLMFDFV CNHMSAKSEW FKNYLQQHPG
    160 170 180 190 200
    FEDFFIAVDP QTDLSAVTRP RALPLLTPFQ MRDHSTRHLW TTFSDDQIDL
    210 220 230 240 250
    NYRSPEVLLA MVDVLLCYLA KGAEYVRLDA VGFMWKEPGT SCIHLEKTHL
    260 270 280 290 300
    IIKLLRSIID NVAPGTVIIT ETNVPHKDNI AYFGAGDDEA HMVYQFSLPP
    310 320 330 340 350
    LVLHAVQKQN VEALCAWAQN LTLPSSNTTW FNFLASHDGI GLNPLRGLLP
    360 370 380 390 400
    ESEILELVEA LQQEGALVNW KNNPDGTRSP YEINVTYMDA LSRRESSDEE
    410 420 430 440 450
    RCARFILAHA ILLSFPGVPA IYIQSILGSR NDYAGVEKLG YNRAINRKKY
    460 470 480 490 500
    HSKEITRELN DEATLRHAVY HELSRLITLR RSHNEFHPDN NFTIDTINSS
    510 520 530 540 550
    VMRIPRSNAD GNCLTGLFNV SKNIQHVNIT NLHGRDLISE VDILGNEITL

    RPWQVMWIK
    Length:559
    Mass (Da):64,186
    Last modified:July 15, 1998 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC05B71B0E0E369C2
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U00096 Genomic DNA Translation: AAC74391.2
    AP009048 Genomic DNA Translation: BAA14886.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    H64879

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_415825.4, NC_000913.3
    WP_000810499.1, NZ_LN832404.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAC74391; AAC74391; b1309
    BAA14886; BAA14886; BAA14886

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    945659

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ecj:JW1302
    eco:b1309

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|1411691.4.peg.970

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U00096 Genomic DNA Translation: AAC74391.2
    AP009048 Genomic DNA Translation: BAA14886.1
    PIRiH64879
    RefSeqiNP_415825.4, NC_000913.3
    WP_000810499.1, NZ_LN832404.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGridi4263230, 11 interactors
    IntActiP76041, 2 interactors
    STRINGi511145.b1309

    Protein family/group databases

    CAZyiGH13 Glycoside Hydrolase Family 13

    Proteomic databases

    jPOSTiP76041
    PaxDbiP76041
    PRIDEiP76041

    Genome annotation databases

    EnsemblBacteriaiAAC74391; AAC74391; b1309
    BAA14886; BAA14886; BAA14886
    GeneIDi945659
    KEGGiecj:JW1302
    eco:b1309
    PATRICifig|1411691.4.peg.970

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...
    EchoBASEi
    EB3669

    Phylogenomic databases

    eggNOGiENOG4107QW3 Bacteria
    COG0366 LUCA
    HOGENOMiHOG000089743
    InParanoidiP76041
    KOiK22597
    PhylomeDBiP76041

    Enzyme and pathway databases

    BioCyciEcoCyc:G6647-MONOMER
    ECOL316407:JW1302-MONOMER
    MetaCyc:G6647-MONOMER

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:P76041

    Family and domain databases

    CDDicd11356 AmyAc_Sucrose_phosphorylase-like_1, 1 hit
    InterProiView protein in InterPro
    IPR033746 GGa_phosphorylase
    IPR006047 Glyco_hydro_13_cat_dom
    IPR017853 Glycoside_hydrolase_SF
    IPR016377 Sucrose_GGa_phosphorylase-rel
    PfamiView protein in Pfam
    PF00128 Alpha-amylase, 1 hit
    PIRSFiPIRSF003059 Sucrose_phosphorylase, 1 hit
    SMARTiView protein in SMART
    SM00642 Aamy, 1 hit
    SUPFAMiSSF51445 SSF51445, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGGAP_ECOLI
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P76041
    Secondary accession number(s): P78149, P78151
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: November 13, 2019
    This is version 138 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
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