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UniProtKB - P76007 (NHAP2_ECOLI)

Entry version 150 (23 Feb 2022)
Sequence version 2 (15 Jul 1999)
Previous versions | rss
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Protein

K(+)/H(+) antiporter NhaP2

Gene

cvrA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

K+/H+ antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels (By similarity).

Participates in control of cell volume in low-osmolarity conditions.

UniRule annotation1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • cell volume homeostasis Source: EcoCyc
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Ion transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:YCGO-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.36.6.11, the monovalent cation:proton antiporter-1 (cpa1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
K(+)/H(+) antiporter NhaP2UniRule annotation
Alternative name(s):
Potassium/proton antiporter NhaP2UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cvrA
Synonyms:nhaP2, ycgO
Ordered Locus Names:b1191, JW5184
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 26HelicalUniRule annotationAdd BLAST21
Transmembranei30 – 50HelicalUniRule annotationAdd BLAST21
Transmembranei58 – 78HelicalUniRule annotationAdd BLAST21
Transmembranei87 – 107HelicalUniRule annotationAdd BLAST21
Transmembranei119 – 141HelicalUniRule annotationAdd BLAST23
Transmembranei156 – 176HelicalUniRule annotationAdd BLAST21
Transmembranei183 – 203HelicalUniRule annotationAdd BLAST21
Transmembranei216 – 236HelicalUniRule annotationAdd BLAST21
Transmembranei237 – 257HelicalUniRule annotationAdd BLAST21
Transmembranei270 – 290HelicalUniRule annotationAdd BLAST21
Transmembranei293 – 313HelicalUniRule annotationAdd BLAST21
Transmembranei334 – 354HelicalUniRule annotationAdd BLAST21
Transmembranei363 – 383HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000523811 – 578K(+)/H(+) antiporter NhaP2Add BLAST578

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P76007

PRoteomics IDEntifications database

More...PRIDEi		P76007

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4261367, 17 interactors
850122, 1 interactor

Protein interaction database and analysis system

More...IntActi		P76007, 1 interactor

STRING: functional protein association networks

More...STRINGi		511145.b1191

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P76007

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini403 – 485RCK C-terminalUniRule annotationAdd BLAST83

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG3263, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005912_9_2_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P76007

Database for complete collections of gene phylogenies

More...PhylomeDBi		P76007

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1530.20, 1 hit
3.30.465.10, 1 hit
3.30.70.1450, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_01075, NhaP2, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006153, Cation/H_exchanger
IPR036318, FAD-bd_PCMH-like_sf
IPR016169, FAD-bd_PCMH_sub2
IPR038770, Na+/solute_symporter_sf
IPR030151, NhaP
IPR023729, NhaP2
IPR006037, RCK_C
IPR036721, RCK_C_sf
IPR005170, Transptr-assoc_dom

The PANTHER Classification System

More...PANTHERi		PTHR32507:SF7, PTHR32507:SF7, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03471, CorC_HlyC, 1 hit
PF00999, Na_H_Exchanger, 1 hit
PF02080, TrkA_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01091, CorC_HlyC, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF116726, SSF116726, 1 hit
SSF56176, SSF56176, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51202, RCK_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P76007-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDATTIISLF ILGSILVTSS ILLSSFSSRL GIPILVIFLA IGMLAGVDGV 
        60         70         80         90        100
GGIPFDNYPF AYMVSNLALA IILLDGGMRT QASSFRVALG PALSLATLGV 
       110        120        130        140        150
LITSGLTGMM AAWLFNLDLI EGLLIGAIVG STDAAAVFSL LGGKGLNERV 
       160        170        180        190        200
GSTLEIESGS NDPMAVFLTI TLIAMIQHHE SNISWMFIVD ILQQFGLGIV 
       210        220        230        240        250
IGLGGGYLLL QMINRIALPA GLYPLLALSG GILIFSLTTA LEGSGILAVY 
       260        270        280        290        300
LCGFLLGNRP IRNRYGILQN FDGLAWLAQI AMFLVLGLLV NPSDLLPIAI 
       310        320        330        340        350
PALILSAWMI FFARPLSVFA GLLPFRGFNL RERVFISWVG LRGAVPIILA 
       360        370        380        390        400
VFPMMAGLEN ARLFFNVAFF VVLVSLLLQG TSLSWAAKKA KVVVPPVGRP 
       410        420        430        440        450
VSRVGLDIHP ENPWEQFVYQ LSADKWCVGA ALRDLHMPKE TRIAALFRDN 
       460        470        480        490        500
QLLHPTGSTR LREGDVLCVI GRERDLPALG KLFSQSPPVA LDQRFFGDFI 
       510        520        530        540        550
LEASAKYADV ALIYGLEDGR EYRDKQQTLG EIVQQLLGAA PVVGDQVEFA 
       560        570 
GMIWTVAEKE DNEVLKIGVR VAEEEAES
Length:578
Mass (Da):62,285
Last modified:July 15, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4637F874E527334A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74275.2
AP009048 Genomic DNA Translation: BAA36046.2

Protein sequence database of the Protein Information Resource

More...PIRi		D64865

NCBI Reference Sequences

More...RefSeqi		NP_415709.2, NC_000913.3
WP_000340194.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC74275; AAC74275; b1191
BAA36046; BAA36046; BAA36046

Database of genes from NCBI RefSeq genomes

More...GeneIDi		945755

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW5184
eco:b1191

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.1095

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74275.2
AP009048 Genomic DNA Translation: BAA36046.2
PIRiD64865
RefSeqiNP_415709.2, NC_000913.3
WP_000340194.1, NZ_LN832404.1

3D structure databases

SMRiP76007
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4261367, 17 interactors
850122, 1 interactor
IntActiP76007, 1 interactor
STRINGi511145.b1191

Protein family/group databases

TCDBi2.A.36.6.11, the monovalent cation:proton antiporter-1 (cpa1) family

Proteomic databases

PaxDbiP76007
PRIDEiP76007

Genome annotation databases

EnsemblBacteriaiAAC74275; AAC74275; b1191
BAA36046; BAA36046; BAA36046
GeneIDi945755
KEGGiecj:JW5184
eco:b1191
PATRICifig|1411691.4.peg.1095

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB3655

Phylogenomic databases

eggNOGiCOG3263, Bacteria
HOGENOMiCLU_005912_9_2_6
InParanoidiP76007
PhylomeDBiP76007

Enzyme and pathway databases

BioCyciEcoCyc:YCGO-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P76007

Family and domain databases

Gene3Di1.20.1530.20, 1 hit
3.30.465.10, 1 hit
3.30.70.1450, 1 hit
HAMAPiMF_01075, NhaP2, 1 hit
InterProiView protein in InterPro
IPR006153, Cation/H_exchanger
IPR036318, FAD-bd_PCMH-like_sf
IPR016169, FAD-bd_PCMH_sub2
IPR038770, Na+/solute_symporter_sf
IPR030151, NhaP
IPR023729, NhaP2
IPR006037, RCK_C
IPR036721, RCK_C_sf
IPR005170, Transptr-assoc_dom
PANTHERiPTHR32507:SF7, PTHR32507:SF7, 1 hit
PfamiView protein in Pfam
PF03471, CorC_HlyC, 1 hit
PF00999, Na_H_Exchanger, 1 hit
PF02080, TrkA_C, 1 hit
SMARTiView protein in SMART
SM01091, CorC_HlyC, 1 hit
SUPFAMiSSF116726, SSF116726, 1 hit
SSF56176, SSF56176, 1 hit
PROSITEiView protein in PROSITE
PS51202, RCK_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNHAP2_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P76007
Secondary accession number(s): O07654
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: February 23, 2022
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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