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UniProtKB - P76007 (NHAP2_ECOLI)
Protein
K(+)/H(+) antiporter NhaP2
Gene
cvrA
Organism
Escherichia coli (strain K12)
Status
Functioni
K+/H+ antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels (By similarity).
Participates in control of cell volume in low-osmolarity conditions.
UniRule annotation1 PublicationGO - Molecular functioni
- flavin adenine dinucleotide binding Source: InterPro
- potassium:proton antiporter activity Source: EcoCyc
GO - Biological processi
- cell volume homeostasis Source: EcoCyc
Keywordsi
Biological process | Antiport, Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Enzyme and pathway databases
BioCyci | EcoCyc:YCGO-MONOMER |
Protein family/group databases
TCDBi | 2.A.36.6.11, the monovalent cation:proton antiporter-1 (cpa1) family |
Names & Taxonomyi
Protein namesi | Recommended name: K(+)/H(+) antiporter NhaP2UniRule annotationAlternative name(s): Potassium/proton antiporter NhaP2UniRule annotation |
Gene namesi | Name:cvrA Synonyms:nhaP2, ycgO Ordered Locus Names:b1191, JW5184 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Plasma Membrane
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 6 – 26 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 30 – 50 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 58 – 78 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 87 – 107 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 119 – 141 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 156 – 176 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 183 – 203 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 216 – 236 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 237 – 257 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 270 – 290 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 293 – 313 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 334 – 354 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 363 – 383 | HelicalUniRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000052381 | 1 – 578 | K(+)/H(+) antiporter NhaP2Add BLAST | 578 |
Proteomic databases
PaxDbi | P76007 |
PRIDEi | P76007 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261367, 17 interactors 850122, 1 interactor |
IntActi | P76007, 1 interactor |
STRINGi | 511145.b1191 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 403 – 485 | RCK C-terminalUniRule annotationAdd BLAST | 83 |
Sequence similaritiesi
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily. [View classification]UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG3263, Bacteria |
HOGENOMi | CLU_005912_9_2_6 |
InParanoidi | P76007 |
PhylomeDBi | P76007 |
Family and domain databases
Gene3Di | 1.20.1530.20, 1 hit 3.30.465.10, 1 hit 3.30.70.1450, 1 hit |
HAMAPi | MF_01075, NhaP2, 1 hit |
InterProi | View protein in InterPro IPR006153, Cation/H_exchanger IPR036318, FAD-bd_PCMH-like_sf IPR016169, FAD-bd_PCMH_sub2 IPR038770, Na+/solute_symporter_sf IPR030151, NhaP IPR023729, NhaP2 IPR006037, RCK_C IPR036721, RCK_C_sf IPR005170, Transptr-assoc_dom |
PANTHERi | PTHR32507:SF7, PTHR32507:SF7, 1 hit |
Pfami | View protein in Pfam PF03471, CorC_HlyC, 1 hit PF00999, Na_H_Exchanger, 1 hit PF02080, TrkA_C, 1 hit |
SMARTi | View protein in SMART SM01091, CorC_HlyC, 1 hit |
SUPFAMi | SSF116726, SSF116726, 1 hit SSF56176, SSF56176, 1 hit |
PROSITEi | View protein in PROSITE PS51202, RCK_C, 1 hit |
i Sequence
Sequence statusi: Complete.
P76007-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDATTIISLF ILGSILVTSS ILLSSFSSRL GIPILVIFLA IGMLAGVDGV
60 70 80 90 100
GGIPFDNYPF AYMVSNLALA IILLDGGMRT QASSFRVALG PALSLATLGV
110 120 130 140 150
LITSGLTGMM AAWLFNLDLI EGLLIGAIVG STDAAAVFSL LGGKGLNERV
160 170 180 190 200
GSTLEIESGS NDPMAVFLTI TLIAMIQHHE SNISWMFIVD ILQQFGLGIV
210 220 230 240 250
IGLGGGYLLL QMINRIALPA GLYPLLALSG GILIFSLTTA LEGSGILAVY
260 270 280 290 300
LCGFLLGNRP IRNRYGILQN FDGLAWLAQI AMFLVLGLLV NPSDLLPIAI
310 320 330 340 350
PALILSAWMI FFARPLSVFA GLLPFRGFNL RERVFISWVG LRGAVPIILA
360 370 380 390 400
VFPMMAGLEN ARLFFNVAFF VVLVSLLLQG TSLSWAAKKA KVVVPPVGRP
410 420 430 440 450
VSRVGLDIHP ENPWEQFVYQ LSADKWCVGA ALRDLHMPKE TRIAALFRDN
460 470 480 490 500
QLLHPTGSTR LREGDVLCVI GRERDLPALG KLFSQSPPVA LDQRFFGDFI
510 520 530 540 550
LEASAKYADV ALIYGLEDGR EYRDKQQTLG EIVQQLLGAA PVVGDQVEFA
560 570
GMIWTVAEKE DNEVLKIGVR VAEEEAES
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74275.2 AP009048 Genomic DNA Translation: BAA36046.2 |
PIRi | D64865 |
RefSeqi | NP_415709.2, NC_000913.3 WP_000340194.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC74275; AAC74275; b1191 BAA36046; BAA36046; BAA36046 |
GeneIDi | 945755 |
KEGGi | ecj:JW5184 eco:b1191 |
PATRICi | fig|1411691.4.peg.1095 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74275.2 AP009048 Genomic DNA Translation: BAA36046.2 |
PIRi | D64865 |
RefSeqi | NP_415709.2, NC_000913.3 WP_000340194.1, NZ_LN832404.1 |
3D structure databases
SMRi | P76007 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261367, 17 interactors 850122, 1 interactor |
IntActi | P76007, 1 interactor |
STRINGi | 511145.b1191 |
Protein family/group databases
TCDBi | 2.A.36.6.11, the monovalent cation:proton antiporter-1 (cpa1) family |
Proteomic databases
PaxDbi | P76007 |
PRIDEi | P76007 |
Genome annotation databases
EnsemblBacteriai | AAC74275; AAC74275; b1191 BAA36046; BAA36046; BAA36046 |
GeneIDi | 945755 |
KEGGi | ecj:JW5184 eco:b1191 |
PATRICi | fig|1411691.4.peg.1095 |
Organism-specific databases
EchoBASEi | EB3655 |
Phylogenomic databases
eggNOGi | COG3263, Bacteria |
HOGENOMi | CLU_005912_9_2_6 |
InParanoidi | P76007 |
PhylomeDBi | P76007 |
Enzyme and pathway databases
BioCyci | EcoCyc:YCGO-MONOMER |
Miscellaneous databases
PROi | PR:P76007 |
Family and domain databases
Gene3Di | 1.20.1530.20, 1 hit 3.30.465.10, 1 hit 3.30.70.1450, 1 hit |
HAMAPi | MF_01075, NhaP2, 1 hit |
InterProi | View protein in InterPro IPR006153, Cation/H_exchanger IPR036318, FAD-bd_PCMH-like_sf IPR016169, FAD-bd_PCMH_sub2 IPR038770, Na+/solute_symporter_sf IPR030151, NhaP IPR023729, NhaP2 IPR006037, RCK_C IPR036721, RCK_C_sf IPR005170, Transptr-assoc_dom |
PANTHERi | PTHR32507:SF7, PTHR32507:SF7, 1 hit |
Pfami | View protein in Pfam PF03471, CorC_HlyC, 1 hit PF00999, Na_H_Exchanger, 1 hit PF02080, TrkA_C, 1 hit |
SMARTi | View protein in SMART SM01091, CorC_HlyC, 1 hit |
SUPFAMi | SSF116726, SSF116726, 1 hit SSF56176, SSF56176, 1 hit |
PROSITEi | View protein in PROSITE PS51202, RCK_C, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NHAP2_ECOLI | |
Accessioni | P76007Primary (citable) accession number: P76007 Secondary accession number(s): O07654 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | July 15, 1999 | |
Last modified: | February 23, 2022 | |
This is version 150 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families