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UniProtKB - P75995 (PDEG_ECOLI)
Protein
Probable cyclic di-GMP phosphodiesterase PdeG
Gene
pdeG
Organism
Escherichia coli (strain K12)
Status
Functioni
Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG.
By similarityCatalytic activityi
- EC:3.1.4.52By similarity
GO - Molecular functioni
- cyclic-guanylate-specific phosphodiesterase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Hydrolase |
Ligand | c-di-GMP |
Enzyme and pathway databases
BioCyci | EcoCyc:G6608-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pdeG1 Publication Synonyms:ycgG Ordered Locus Names:b1168, JW5174 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Sequence analysis
Note: Found associated with the RNA degradosome.1 Publication
Plasma Membrane
- plasma membrane Source: EcoCyc
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 4 – 24 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 217 – 237 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000168853 | 1 – 507 | Probable cyclic di-GMP phosphodiesterase PdeGAdd BLAST | 507 |
Proteomic databases
PaxDbi | P75995 |
PRIDEi | P75995 |
Expressioni
Inductioni
Induced by 0.3 M NaCl in an RpoS-dependent fashion.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261455, 14 interactors |
DIPi | DIP-11554N |
IntActi | P75995, 1 interactor |
STRINGi | 511145.b1168 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 246 – 500 | EALPROSITE-ProRule annotationAdd BLAST | 255 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2200, Bacteria |
HOGENOMi | CLU_000445_131_0_6 |
InParanoidi | P75995 |
OMAi | DKQMRNT |
PhylomeDBi | P75995 |
Family and domain databases
CDDi | cd01948, EAL, 1 hit |
Gene3Di | 3.20.20.450, 1 hit |
InterProi | View protein in InterPro IPR024744, CSS-motif_dom IPR001633, EAL_dom IPR035919, EAL_sf |
Pfami | View protein in Pfam PF12792, CSS-motif, 1 hit PF00563, EAL, 1 hit |
SMARTi | View protein in SMART SM00052, EAL, 1 hit |
SUPFAMi | SSF141868, SSF141868, 1 hit |
PROSITEi | View protein in PROSITE PS50883, EAL, 1 hit |
i Sequence
Sequence statusi: Complete.
P75995-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRNTLIPILV AICLFITGVA ILNIQLWYSA KAEYLAGARY AANNINHILE
60 70 80 90 100
EASQATQTAV NIAGKECNLE EQYQLGTEAA LKPHLRTIII LKQGIVWCTS
110 120 130 140 150
LPGNRVLLSR IPVFPDSNLL LAPAIDTVNR LPILLYQNQF ADTRILVTIS
160 170 180 190 200
DQHIRGALNV PLKGVRYVLR VADDIIGPTG DVMTLNGHYP YTEKVHSTKY
210 220 230 240 250
HFTIIFNPPP LFSFYRLIDK GFGILIFILL IACAAAFLLD RYFNKSATPE
260 270 280 290 300
EILRRAINNG EIVPFYQPVV NGREGTLRGV EVLARWKQPH GGYISPAAFI
310 320 330 340 350
PLAEKSGLIV PLTQSLMNQV ARQMNAIASK LPEGFHIGIN FSASHIISPT
360 370 380 390 400
FVDECLNFRD SFTRRDLNLV LEVTEREPLN VDESLVQRLN ILHENGFVIA
410 420 430 440 450
LDDFGTGYSG LSYLHDLHID YIKIDHSFVG RVNADPESTR ILDCVLDLAR
460 470 480 490 500
KLSISIVAEG VETKEQLDYL NQNYITFQQG YYFYKPVTYI DLVKIILSKP
KVKVVVE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74252.2 AP009048 Genomic DNA Translation: BAA36000.2 |
PIRi | E64862 |
RefSeqi | NP_415686.2, NC_000913.3 WP_001246499.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC74252; AAC74252; b1168 BAA36000; BAA36000; BAA36000 |
GeneIDi | 945738 |
KEGGi | ecj:JW5174 eco:b1168 |
PATRICi | fig|1411691.4.peg.1123 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74252.2 AP009048 Genomic DNA Translation: BAA36000.2 |
PIRi | E64862 |
RefSeqi | NP_415686.2, NC_000913.3 WP_001246499.1, NZ_LN832404.1 |
3D structure databases
AlphaFoldDBi | P75995 |
SMRi | P75995 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261455, 14 interactors |
DIPi | DIP-11554N |
IntActi | P75995, 1 interactor |
STRINGi | 511145.b1168 |
Proteomic databases
PaxDbi | P75995 |
PRIDEi | P75995 |
Genome annotation databases
EnsemblBacteriai | AAC74252; AAC74252; b1168 BAA36000; BAA36000; BAA36000 |
GeneIDi | 945738 |
KEGGi | ecj:JW5174 eco:b1168 |
PATRICi | fig|1411691.4.peg.1123 |
Organism-specific databases
EchoBASEi | EB3647 |
Phylogenomic databases
eggNOGi | COG2200, Bacteria |
HOGENOMi | CLU_000445_131_0_6 |
InParanoidi | P75995 |
OMAi | DKQMRNT |
PhylomeDBi | P75995 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6608-MONOMER |
Miscellaneous databases
PROi | PR:P75995 |
Family and domain databases
CDDi | cd01948, EAL, 1 hit |
Gene3Di | 3.20.20.450, 1 hit |
InterProi | View protein in InterPro IPR024744, CSS-motif_dom IPR001633, EAL_dom IPR035919, EAL_sf |
Pfami | View protein in Pfam PF12792, CSS-motif, 1 hit PF00563, EAL, 1 hit |
SMARTi | View protein in SMART SM00052, EAL, 1 hit |
SUPFAMi | SSF141868, SSF141868, 1 hit |
PROSITEi | View protein in PROSITE PS50883, EAL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PDEG_ECOLI | |
Accessioni | P75995Primary (citable) accession number: P75995 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | April 27, 2001 | |
Last modified: | May 25, 2022 | |
This is version 125 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |