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Protein

Prophage integrase IntE

Gene

intE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Integrase from the cryptic lambdoic prophage e14. Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei340O-(3'-phospho-DNA)-tyrosine intermediateBy similarity1

GO - Molecular functioni

  • DNA binding Source: InterPro
  • integrase activity Source: InterPro
  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processDNA integration, DNA recombination, Viral genome integration, Virus entry into host cell

Enzyme and pathway databases

BioCyciEcoCyc:EG12370-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Prophage integrase IntECurated
Alternative name(s):
Int(Lambda)
Prophage e14 integrase
Prophage lambda integrase
Gene namesi
Name:intE
Synonyms:ycfI
Ordered Locus Names:b1140, JW1126
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12370 intE

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001975141 – 375Prophage integrase IntEAdd BLAST375

Proteomic databases

PaxDbiP75969
PRIDEiP75969

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4263213, 16 interactors
DIPiDIP-10037N
IntActiP75969, 3 interactors
STRINGi316407.4062718

Structurei

3D structure databases

ProteinModelPortaliP75969
SMRiP75969
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 'phage' integrase family.Curated

Phylogenomic databases

eggNOGiENOG4108I1J Bacteria
COG0582 LUCA
HOGENOMiHOG000119139

Family and domain databases

Gene3Di1.10.150.130, 1 hit
1.10.443.10, 1 hit
InterProiView protein in InterPro
IPR016177 DNA-bd_dom_sf
IPR011010 DNA_brk_join_enz
IPR013762 Integrase-like_cat_sf
IPR002104 Integrase_catalytic
IPR015094 Integrase_lambda-typ_DNA-bd_N
IPR010998 Integrase_recombinase_N
PfamiView protein in Pfam
PF09003 Arm-DNA-bind_1, 1 hit
PF00589 Phage_integrase, 1 hit
SUPFAMiSSF54171 SSF54171, 1 hit
SSF56349 SSF56349, 1 hit

Sequencei

Sequence statusi: Complete.

P75969-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAARPRKNNV SVPNLYPLYS RKVNKVYWRY KHPVTGKFHA LGTNEAEAIA
60 70 80 90 100
IATEANTRLA EQRTRQILAI SDRIATSKGK AITTSTWLDR YQAIQDDRLK
110 120 130 140 150
SGDIRLNTYK QKAKPVSLLR ERAGMKLISA VDVRDIAQLL DEYIAAGRPR
160 170 180 190 200
MAQVVRSVLI DVFKEAQHYG EVPPGYNPAL ATKQPRRKIT RQRLSLEEWK
210 220 230 240 250
KIFDIADATH RYMGNAMLLA LVTGQRLGDI SRMKFSDIWD DHLHVIQEKT
260 270 280 290 300
GSKIAIPLSL RLNAINWSLR DVVARCRDYA VSAYLVHFFR STSQAERGAQ
310 320 330 340 350
VKANTLTMNF SKARDLARID WGEGSPATFH EQRSLSERLY KEQGLDTQKL
360 370
LGHKTQQQTD RYHDDRGKGW SKVAL
Length:375
Mass (Da):42,799
Last modified:February 1, 1997 - v1
Checksum:i8F49F9805C7AA2B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74224.1
AP009048 Genomic DNA Translation: BAA35969.1
PIRiA64859
RefSeqiNP_415658.1, NC_000913.3
WP_000741310.1, NZ_CP010440.1

Genome annotation databases

EnsemblBacteriaiAAC74224; AAC74224; b1140
BAA35969; BAA35969; BAA35969
GeneIDi948034
KEGGiecj:JW1126
eco:b1140
PATRICifig|511145.12.peg.1186

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74224.1
AP009048 Genomic DNA Translation: BAA35969.1
PIRiA64859
RefSeqiNP_415658.1, NC_000913.3
WP_000741310.1, NZ_CP010440.1

3D structure databases

ProteinModelPortaliP75969
SMRiP75969
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263213, 16 interactors
DIPiDIP-10037N
IntActiP75969, 3 interactors
STRINGi316407.4062718

Proteomic databases

PaxDbiP75969
PRIDEiP75969

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74224; AAC74224; b1140
BAA35969; BAA35969; BAA35969
GeneIDi948034
KEGGiecj:JW1126
eco:b1140
PATRICifig|511145.12.peg.1186

Organism-specific databases

EchoBASEiEB2273
EcoGeneiEG12370 intE

Phylogenomic databases

eggNOGiENOG4108I1J Bacteria
COG0582 LUCA
HOGENOMiHOG000119139

Enzyme and pathway databases

BioCyciEcoCyc:EG12370-MONOMER

Miscellaneous databases

PROiPR:P75969

Family and domain databases

Gene3Di1.10.150.130, 1 hit
1.10.443.10, 1 hit
InterProiView protein in InterPro
IPR016177 DNA-bd_dom_sf
IPR011010 DNA_brk_join_enz
IPR013762 Integrase-like_cat_sf
IPR002104 Integrase_catalytic
IPR015094 Integrase_lambda-typ_DNA-bd_N
IPR010998 Integrase_recombinase_N
PfamiView protein in Pfam
PF09003 Arm-DNA-bind_1, 1 hit
PF00589 Phage_integrase, 1 hit
SUPFAMiSSF54171 SSF54171, 1 hit
SSF56349 SSF56349, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINTE_ECOLI
AccessioniPrimary (citable) accession number: P75969
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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