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UniProtKB - P75958 (LOLE_ECOLI)
Protein
Lipoprotein-releasing system transmembrane protein LolE
Gene
lolE
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of an ATP-dependent transport system LolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA.
GO - Molecular functioni
- lipoprotein releasing activity Source: EcoCyc
GO - Biological processi
- lipoprotein localization to outer membrane Source: EcoCyc
- lipoprotein transport Source: InterPro
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:YCFW-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.125.1, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Lipoprotein-releasing system transmembrane protein LolE |
Gene namesi | Name:lolE Synonyms:ycfW Ordered Locus Names:b1118, JW1104 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- ATP-binding cassette (ABC) transporter complex Source: ComplexPortal
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
- plasma membrane protein complex Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 25 – 45 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 275 – 295 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 317 – 337 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 377 – 397 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000201818 | 2 – 414 | Lipoprotein-releasing system transmembrane protein LolEAdd BLAST | 413 |
Proteomic databases
jPOSTi | P75958 |
PaxDbi | P75958 |
PRIDEi | P75958 |
Interactioni
Binary interactionsi
P75958
With | #Exp. | IntAct |
---|---|---|
pal [P0A912] | 2 | EBI-1125190,EBI-1124760 |
Protein-protein interaction databases
BioGRIDi | 4262905, 349 interactors 850037, 5 interactors |
ComplexPortali | CPX-4262, LolCDE lipoprotein ABC transporter complex |
IntActi | P75958, 10 interactors |
MINTi | P75958 |
STRINGi | 511145.b1118 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P75958 |
SMRi | P75958 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG4591, Bacteria |
HOGENOMi | CLU_000604_8_1_6 |
InParanoidi | P75958 |
OMAi | ERTQMIG |
PhylomeDBi | P75958 |
Family and domain databases
InterProi | View protein in InterPro IPR003838, ABC3_permease_dom IPR011925, LolCE_TM IPR011926, LolE_gammaproteobact IPR025857, MacB_PCD |
Pfami | View protein in Pfam PF02687, FtsX, 1 hit PF12704, MacB_PCD, 1 hit |
TIGRFAMsi | TIGR02212, lolCE, 1 hit TIGR02213, lolE_release, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P75958-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAMPLSLLIG LRFSRGRRRG GMVSLISVIS TIGIALGVAV LIVGLSAMNG
60 70 80 90 100
FERELNNRIL AVVPHGEIEA VDQPWTNWQE ALDHVQKVPG IAAAAPYINF
110 120 130 140 150
TGLVESGANL RAIQVKGVNP QQEQRLSALP SFVQGDAWRN FKAGEQQIII
160 170 180 190 200
GKGVADALKV KQGDWVSIMI PNSNPEHKLM QPKRVRLHVA GILQLSGQLD
210 220 230 240 250
HSFAMIPLAD AQQYLDMGSS VSGIALKMTD VFNANKLVRD AGEVTNSYVY
260 270 280 290 300
IKSWIGTYGY MYRDIQMIRA IMYLAMVLVI GVACFNIVST LVMAVKDKSG
310 320 330 340 350
DIAVLRTLGA KDGLIRAIFV WYGLLAGLFG SLCGVIIGVV VSLQLTPIIE
360 370 380 390 400
WIEKLIGHQF LSSDIYFIDF LPSELHWLDV FYVLVTALLL SLLASWYPAR
410
RASNIDPARV LSGQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74202.1 AP009048 Genomic DNA Translation: BAA35938.1 |
PIRi | C64856 |
RefSeqi | NP_415636.1, NC_000913.3 WP_001251348.1, NZ_SSZK01000019.1 |
Genome annotation databases
EnsemblBacteriai | AAC74202; AAC74202; b1118 BAA35938; BAA35938; BAA35938 |
GeneIDi | 945665 |
KEGGi | ecj:JW1104 eco:b1118 |
PATRICi | fig|511145.12.peg.1164 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74202.1 AP009048 Genomic DNA Translation: BAA35938.1 |
PIRi | C64856 |
RefSeqi | NP_415636.1, NC_000913.3 WP_001251348.1, NZ_SSZK01000019.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7ARH | electron microscopy | 3.30 | E | 1-414 | [»] | |
7ARI | electron microscopy | 3.40 | E | 1-414 | [»] | |
7ARJ | electron microscopy | 3.20 | E | 1-414 | [»] | |
7ARK | electron microscopy | 4.10 | E | 1-414 | [»] | |
7ARL | electron microscopy | 3.20 | E | 1-414 | [»] | |
7ARM | electron microscopy | 3.60 | E | 1-414 | [»] | |
AlphaFoldDBi | P75958 | |||||
SMRi | P75958 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4262905, 349 interactors 850037, 5 interactors |
ComplexPortali | CPX-4262, LolCDE lipoprotein ABC transporter complex |
IntActi | P75958, 10 interactors |
MINTi | P75958 |
STRINGi | 511145.b1118 |
Protein family/group databases
TCDBi | 3.A.1.125.1, the atp-binding cassette (abc) superfamily |
Proteomic databases
jPOSTi | P75958 |
PaxDbi | P75958 |
PRIDEi | P75958 |
Genome annotation databases
EnsemblBacteriai | AAC74202; AAC74202; b1118 BAA35938; BAA35938; BAA35938 |
GeneIDi | 945665 |
KEGGi | ecj:JW1104 eco:b1118 |
PATRICi | fig|511145.12.peg.1164 |
Organism-specific databases
EchoBASEi | EB3215 |
Phylogenomic databases
eggNOGi | COG4591, Bacteria |
HOGENOMi | CLU_000604_8_1_6 |
InParanoidi | P75958 |
OMAi | ERTQMIG |
PhylomeDBi | P75958 |
Enzyme and pathway databases
BioCyci | EcoCyc:YCFW-MONOMER |
Miscellaneous databases
PROi | PR:P75958 |
Family and domain databases
InterProi | View protein in InterPro IPR003838, ABC3_permease_dom IPR011925, LolCE_TM IPR011926, LolE_gammaproteobact IPR025857, MacB_PCD |
Pfami | View protein in Pfam PF02687, FtsX, 1 hit PF12704, MacB_PCD, 1 hit |
TIGRFAMsi | TIGR02212, lolCE, 1 hit TIGR02213, lolE_release, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LOLE_ECOLI | |
Accessioni | P75958Primary (citable) accession number: P75958 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 153 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families