UniProtKB - P75952 (COMR_ECOLI)
Protein
HTH-type transcriptional repressor ComR
Gene
comR
Organism
Escherichia coli (strain K12)
Status
Functioni
Represses expression of BhsA/ComC by binding to its promoter region in the absence of copper.1 Publication
Activity regulationi
Binding to the promoter region of BhsA/ComC is released in the presence of copper.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 41 – 60 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- DNA binding Source: EcoCyc
- DNA-binding transcription factor activity Source: GO_Central
- transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: EcoCyc
- regulation of transcription, DNA-templated Source: GO_Central
- response to copper ion Source: EcoCyc
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Copper |
Enzyme and pathway databases
BioCyci | EcoCyc:G6569-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: HTH-type transcriptional repressor ComRAlternative name(s): Copper outer membrane regulator |
Gene namesi | Name:comR Synonyms:ycfQ Ordered Locus Names:b1111, JW5159 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Deletion mutants contain lower cytoplasmic copper levels compared to the wild-type strain when exposed to copper.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070638 | 1 – 210 | HTH-type transcriptional repressor ComRAdd BLAST | 210 |
Proteomic databases
jPOSTi | P75952 |
PaxDbi | P75952 |
PRIDEi | P75952 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260995, 6 interactors |
STRINGi | 511145.b1111 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 78 | HTH tetR-typePROSITE-ProRule annotationAdd BLAST | 61 |
Phylogenomic databases
eggNOGi | COG1309, Bacteria |
HOGENOMi | CLU_069356_28_0_6 |
InParanoidi | P75952 |
PhylomeDBi | P75952 |
Family and domain databases
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001647, HTH_TetR IPR036271, Tet_transcr_reg_TetR-rel_C_sf |
Pfami | View protein in Pfam PF00440, TetR_N, 1 hit |
PRINTSi | PR00455, HTHTETR |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF48498, SSF48498, 1 hit |
PROSITEi | View protein in PROSITE PS50977, HTH_TETR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P75952-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATDSTQCVK KSRGRPKVFD RDAALDKAMK LFWQHGYEAT SLADLVEATG
60 70 80 90 100
AKAPTLYAEF TNKEGLFRAV LDRYIDRFAA KHEAQLFCEE KSVESALADY
110 120 130 140 150
FAAIANCFTS KDTPAGCFMI NNCTTLSPDS GDIANTLKSR HAMQERTLQQ
160 170 180 190 200
FLCQRQARGE IPPHCDVTHL AEFLNCIIQG MSISAREGAS LEKLMQIAGT
210
TLRLWPELVK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74195.2 AP009048 Genomic DNA Translation: BAA35926.2 |
RefSeqi | NP_415629.4, NC_000913.3 WP_001336528.1, NZ_SSZK01000019.1 |
Genome annotation databases
EnsemblBacteriai | AAC74195; AAC74195; b1111 BAA35926; BAA35926; BAA35926 |
GeneIDi | 947425 |
KEGGi | ecj:JW5159 eco:b1111 |
PATRICi | fig|511145.12.peg.1155 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74195.2 AP009048 Genomic DNA Translation: BAA35926.2 |
RefSeqi | NP_415629.4, NC_000913.3 WP_001336528.1, NZ_SSZK01000019.1 |
3D structure databases
SMRi | P75952 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260995, 6 interactors |
STRINGi | 511145.b1111 |
Proteomic databases
jPOSTi | P75952 |
PaxDbi | P75952 |
PRIDEi | P75952 |
Genome annotation databases
EnsemblBacteriai | AAC74195; AAC74195; b1111 BAA35926; BAA35926; BAA35926 |
GeneIDi | 947425 |
KEGGi | ecj:JW5159 eco:b1111 |
PATRICi | fig|511145.12.peg.1155 |
Organism-specific databases
EchoBASEi | EB3209 |
Phylogenomic databases
eggNOGi | COG1309, Bacteria |
HOGENOMi | CLU_069356_28_0_6 |
InParanoidi | P75952 |
PhylomeDBi | P75952 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6569-MONOMER |
Miscellaneous databases
PROi | PR:P75952 |
Family and domain databases
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001647, HTH_TetR IPR036271, Tet_transcr_reg_TetR-rel_C_sf |
Pfami | View protein in Pfam PF00440, TetR_N, 1 hit |
PRINTSi | PR00455, HTHTETR |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF48498, SSF48498, 1 hit |
PROSITEi | View protein in PROSITE PS50977, HTH_TETR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COMR_ECOLI | |
Accessioni | P75952Primary (citable) accession number: P75952 Secondary accession number(s): Q9R7N8, Q9R7N9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | December 15, 1998 | |
Last modified: | December 2, 2020 | |
This is version 137 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |