UniProtKB - P75948 (THIK_ECOLI)
Protein
Thiamine kinase
Gene
thiK
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalyzes the phosphorylation of thiamine to thiamine phosphate.
Catalytic activityi
- EC:2.7.1.89
: thiamine diphosphate biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes thiamine phosphate from thiamine.Proteins known to be involved in this subpathway in this organism are:
- Thiamine kinase (thiK), Thiamine kinase (thiK), Thiamine kinase (thiK), Thiamine kinase (thiK), Thiamine kinase (thiK)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes thiamine phosphate from thiamine, the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- thiamine kinase activity Source: EcoCyc
GO - Biological processi
- thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
- thiamine metabolic process Source: InterPro
Keywordsi
Molecular function | Kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:THIKIN-MONOMER ECOL316407:JW1092-MONOMER MetaCyc:THIKIN-MONOMER |
UniPathwayi | UPA00060;UER00596 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:thiK Synonyms:ycfN Ordered Locus Names:b1106, JW1092 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218057 | 1 – 274 | Thiamine kinaseAdd BLAST | 274 |
Proteomic databases
PaxDbi | P75948 |
PRIDEi | P75948 |
Interactioni
Protein-protein interaction databases
BioGridi | 4260073, 122 interactors |
IntActi | P75948, 5 interactors |
STRINGi | 511145.b1106 |
Family & Domainsi
Sequence similaritiesi
Belongs to the thiamine kinase family.Curated
Phylogenomic databases
eggNOGi | ENOG4108RUM Bacteria COG0510 LUCA |
HOGENOMi | HOG000219316 |
KOi | K07251 |
Family and domain databases
HAMAPi | MF_01604 Thiamine_kinase, 1 hit |
InterProi | View protein in InterPro IPR002575 Aminoglycoside_PTrfase IPR011009 Kinase-like_dom_sf IPR014093 Thiamine_kinase |
Pfami | View protein in Pfam PF01636 APH, 1 hit |
SUPFAMi | SSF56112 SSF56112, 1 hit |
TIGRFAMsi | TIGR02721 ycfN_thiK, 1 hit |
i Sequence
Sequence statusi: Complete.
P75948-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPFRSNNPIT RDELLSRFFP QYHPVTTFNS GLSGGSFLIE HQGQRFVVRQ
60 70 80 90 100
PHDPDAPQSA FLRQYRALSQ LPACIAPKPH LYLRDWMVVD YLPGAVKTYL
110 120 130 140 150
PDTNELAGLL YYLHQQPRFG WRITLLPLLE LYWQQSDPAR RTVGWLRMLK
160 170 180 190 200
RLRKAREPRP LRLSPLHMDV HAGNLVHSAS GLKLIDWEYA GDGDIALELA
210 220 230 240 250
AVWVENTEQH RQLVNDYATR AKIYPAQLWR QVRRWFPWLL MLKAGWFEYR
260 270
WRQTGDQQFI RLADDTWRQL LIKQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74190.1 AP009048 Genomic DNA Translation: BAA35913.1 |
PIRi | G64854 |
RefSeqi | NP_415624.1, NC_000913.3 WP_001116592.1, NZ_SSZK01000019.1 |
Genome annotation databases
EnsemblBacteriai | AAC74190; AAC74190; b1106 BAA35913; BAA35913; BAA35913 |
GeneIDi | 948525 |
KEGGi | ecj:JW1092 eco:b1106 |
PATRICi | fig|1411691.4.peg.1161 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74190.1 AP009048 Genomic DNA Translation: BAA35913.1 |
PIRi | G64854 |
RefSeqi | NP_415624.1, NC_000913.3 WP_001116592.1, NZ_SSZK01000019.1 |
3D structure databases
SMRi | P75948 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 4260073, 122 interactors |
IntActi | P75948, 5 interactors |
STRINGi | 511145.b1106 |
Proteomic databases
PaxDbi | P75948 |
PRIDEi | P75948 |
Genome annotation databases
EnsemblBacteriai | AAC74190; AAC74190; b1106 BAA35913; BAA35913; BAA35913 |
GeneIDi | 948525 |
KEGGi | ecj:JW1092 eco:b1106 |
PATRICi | fig|1411691.4.peg.1161 |
Organism-specific databases
EchoBASEi | EB3206 |
Phylogenomic databases
eggNOGi | ENOG4108RUM Bacteria COG0510 LUCA |
HOGENOMi | HOG000219316 |
KOi | K07251 |
Enzyme and pathway databases
UniPathwayi | UPA00060;UER00596 |
BioCyci | EcoCyc:THIKIN-MONOMER ECOL316407:JW1092-MONOMER MetaCyc:THIKIN-MONOMER |
Miscellaneous databases
PROi | PR:P75948 |
Family and domain databases
HAMAPi | MF_01604 Thiamine_kinase, 1 hit |
InterProi | View protein in InterPro IPR002575 Aminoglycoside_PTrfase IPR011009 Kinase-like_dom_sf IPR014093 Thiamine_kinase |
Pfami | View protein in Pfam PF01636 APH, 1 hit |
SUPFAMi | SSF56112 SSF56112, 1 hit |
TIGRFAMsi | TIGR02721 ycfN_thiK, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | THIK_ECOLI | |
Accessioni | P75948Primary (citable) accession number: P75948 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | February 1, 1997 | |
Last modified: | November 13, 2019 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene - PATHWAY comments
Index of metabolic and biosynthesis pathways