UniProtKB - P75942 (FLGJ_ECOLI)
Protein
Peptidoglycan hydrolase FlgJ
Gene
flgJ
Organism
Escherichia coli (strain K12)
Status
Functioni
Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space.By similarity
Miscellaneous
Probably exported via the flagellum-specific export pathway.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 220 | Sequence analysis | 1 | |
Active sitei | 245 | Sequence analysis | 1 |
GO - Molecular functioni
- amidase activity Source: InterPro
- hydrolase activity, acting on glycosyl bonds Source: UniProtKB-KW
GO - Biological processi
- bacterial-type flagellum assembly Source: InterPro
- bacterial-type flagellum-dependent cell motility Source: EcoCyc
- cell wall organization Source: UniProtKB-KW
- metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Glycosidase, Hydrolase |
Biological process | Bacterial flagellum biogenesis, Cell wall biogenesis/degradation |
Enzyme and pathway databases
BioCyci | EcoCyc:G366-MONOMER |
Protein family/group databases
CAZyi | GH73, Glycoside Hydrolase Family 73 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:flgJ Synonyms:fla FX, flaZ Ordered Locus Names:b1081, JW1068 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Periplasm By similarity
GO - Cellular componenti
- periplasmic space Source: UniProtKB-SubCell
Keywords - Cellular componenti
PeriplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000165705 | 1 – 313 | Peptidoglycan hydrolase FlgJAdd BLAST | 313 |
Proteomic databases
PaxDbi | P75942 |
PRIDEi | P75942 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261020, 118 interactors |
IntActi | P75942, 11 interactors |
STRINGi | 511145.b1081 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 148 – 313 | CatalyticAdd BLAST | 166 |
Sequence similaritiesi
In the N-terminal section; belongs to the FlgJ family.Curated
In the C-terminal section; belongs to the glycosyl hydrolase 73 family.Curated
Phylogenomic databases
eggNOGi | COG1705, Bacteria COG3951, Bacteria |
HOGENOMi | CLU_013771_3_0_6 |
InParanoidi | P75942 |
Family and domain databases
InterProi | View protein in InterPro IPR019301, Flagellar_prot_FlgJ_N IPR013377, FlaJ IPR002901, MGlyc_endo_b_GlcNAc-like_dom |
Pfami | View protein in Pfam PF01832, Glucosaminidase, 1 hit PF10135, Rod-binding, 1 hit |
SMARTi | View protein in SMART SM00047, LYZ2, 1 hit |
TIGRFAMsi | TIGR02541, flagell_FlgJ, 1 hit |
i Sequence
Sequence statusi: Complete.
P75942-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MISDSKLLAS AAWDAQSLNE LKAKAGEDPA ANIRPVARQV EGMFVQMMLK
60 70 80 90 100
SMRDALPKDG LFSSEHTRLY TSMYDQQIAQ QMTAGKGLGL AEMMVKQMTP
110 120 130 140 150
EQPLPEESTP AAPMKFPLET VVRYQNQALS QLVQKAVPRN YDDSLPGDSK
160 170 180 190 200
AFLAQLSLPA QLASQQSGVP HHLILAQAAL ESGWGQRQIR RENGEPSYNL
210 220 230 240 250
FGVKASGNWK GPVTEITTTE YENGEAKKVK AKFRVYSSYL EALSDYVGLL
260 270 280 290 300
TRNPRYAAVT TAASAEQGAQ ALQDAGYATD PHYARKLTNM IQQMKSISDK
310
VSKTYSMNID NLF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74165.1 AP009048 Genomic DNA Translation: BAA35890.1 |
PIRi | F64851 |
RefSeqi | NP_415599.1, NC_000913.3 WP_001295441.1, NZ_SSZK01000053.1 |
Genome annotation databases
EnsemblBacteriai | AAC74165; AAC74165; b1081 BAA35890; BAA35890; BAA35890 |
GeneIDi | 57731868 947456 |
KEGGi | ecj:JW1068 eco:b1081 |
PATRICi | fig|1411691.4.peg.1187 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74165.1 AP009048 Genomic DNA Translation: BAA35890.1 |
PIRi | F64851 |
RefSeqi | NP_415599.1, NC_000913.3 WP_001295441.1, NZ_SSZK01000053.1 |
3D structure databases
SMRi | P75942 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261020, 118 interactors |
IntActi | P75942, 11 interactors |
STRINGi | 511145.b1081 |
Protein family/group databases
CAZyi | GH73, Glycoside Hydrolase Family 73 |
Proteomic databases
PaxDbi | P75942 |
PRIDEi | P75942 |
Genome annotation databases
EnsemblBacteriai | AAC74165; AAC74165; b1081 BAA35890; BAA35890; BAA35890 |
GeneIDi | 57731868 947456 |
KEGGi | ecj:JW1068 eco:b1081 |
PATRICi | fig|1411691.4.peg.1187 |
Organism-specific databases
EchoBASEi | EB4020 |
Phylogenomic databases
eggNOGi | COG1705, Bacteria COG3951, Bacteria |
HOGENOMi | CLU_013771_3_0_6 |
InParanoidi | P75942 |
Enzyme and pathway databases
BioCyci | EcoCyc:G366-MONOMER |
Miscellaneous databases
PROi | PR:P75942 |
Family and domain databases
InterProi | View protein in InterPro IPR019301, Flagellar_prot_FlgJ_N IPR013377, FlaJ IPR002901, MGlyc_endo_b_GlcNAc-like_dom |
Pfami | View protein in Pfam PF01832, Glucosaminidase, 1 hit PF10135, Rod-binding, 1 hit |
SMARTi | View protein in SMART SM00047, LYZ2, 1 hit |
TIGRFAMsi | TIGR02541, flagell_FlgJ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FLGJ_ECOLI | |
Accessioni | P75942Primary (citable) accession number: P75942 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries