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Protein

Peptidoglycan hydrolase FlgJ

Gene

flgJ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space.By similarity

Miscellaneous

Probably exported via the flagellum-specific export pathway.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei220Sequence analysis1
Active sitei245Sequence analysis1

GO - Molecular functioni

GO - Biological processi

  • bacterial-type flagellum assembly Source: InterPro
  • bacterial-type flagellum-dependent cell motility Source: EcoCyc
  • cell wall organization Source: UniProtKB-KW
  • metabolic process Source: UniProtKB-KW

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processBacterial flagellum biogenesis, Cell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciEcoCyc:G366-MONOMER

Protein family/group databases

CAZyiGH73 Glycoside Hydrolase Family 73

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan hydrolase FlgJ (EC:3.2.1.-)
Alternative name(s):
Muramidase FlgJ
Gene namesi
Name:flgJ
Synonyms:fla FX, flaZ
Ordered Locus Names:b1081, JW1068
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14272 flgJ

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001657051 – 313Peptidoglycan hydrolase FlgJAdd BLAST313

Proteomic databases

PaxDbiP75942
PRIDEiP75942

Interactioni

Protein-protein interaction databases

BioGridi4261020, 118 interactors
IntActiP75942, 11 interactors
STRINGi316385.ECDH10B_1152

Structurei

3D structure databases

ProteinModelPortaliP75942
SMRiP75942
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni148 – 313CatalyticAdd BLAST166

Sequence similaritiesi

In the N-terminal section; belongs to the FlgJ family.Curated
In the C-terminal section; belongs to the glycosyl hydrolase 73 family.Curated

Phylogenomic databases

eggNOGiENOG4108ZW7 Bacteria
COG1705 LUCA
COG3951 LUCA
HOGENOMiHOG000265620
InParanoidiP75942
KOiK02395
OMAiEGVFVQM

Family and domain databases

InterProiView protein in InterPro
IPR019301 Flagellar_prot_FlgJ_N
IPR013377 FlaJ
IPR002901 MGlyc_endo_b_GlcNAc-like_dom
PfamiView protein in Pfam
PF01832 Glucosaminidase, 1 hit
PF10135 Rod-binding, 1 hit
SMARTiView protein in SMART
SM00047 LYZ2, 1 hit
TIGRFAMsiTIGR02541 flagell_FlgJ, 1 hit

Sequencei

Sequence statusi: Complete.

P75942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISDSKLLAS AAWDAQSLNE LKAKAGEDPA ANIRPVARQV EGMFVQMMLK
60 70 80 90 100
SMRDALPKDG LFSSEHTRLY TSMYDQQIAQ QMTAGKGLGL AEMMVKQMTP
110 120 130 140 150
EQPLPEESTP AAPMKFPLET VVRYQNQALS QLVQKAVPRN YDDSLPGDSK
160 170 180 190 200
AFLAQLSLPA QLASQQSGVP HHLILAQAAL ESGWGQRQIR RENGEPSYNL
210 220 230 240 250
FGVKASGNWK GPVTEITTTE YENGEAKKVK AKFRVYSSYL EALSDYVGLL
260 270 280 290 300
TRNPRYAAVT TAASAEQGAQ ALQDAGYATD PHYARKLTNM IQQMKSISDK
310
VSKTYSMNID NLF
Length:313
Mass (Da):34,475
Last modified:February 1, 1997 - v1
Checksum:iC4B3CB8F36751CDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74165.1
AP009048 Genomic DNA Translation: BAA35890.1
PIRiF64851
RefSeqiNP_415599.1, NC_000913.3
WP_001295441.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74165; AAC74165; b1081
BAA35890; BAA35890; BAA35890
GeneIDi947456
KEGGiecj:JW1068
eco:b1081
PATRICifig|1411691.4.peg.1187

Similar proteinsi

Entry informationi

Entry nameiFLGJ_ECOLI
AccessioniPrimary (citable) accession number: P75942
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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