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Protein

Putative inactive ferrous iron permease EfeU

Gene

efeU

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Caution

Could be the product of a pseudogene. Strain K12 contains a truncated, inactive permease due to a frameshift in position 34 that produces two separate ORFs. The sequence shown here is a reconstruction originating from EcoGene.Curated

GO - Molecular functioni

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-4386
MetaCyc:G6525-MONOMER

Protein family/group databases

TCDBi2.A.108.2.3 the iron/lead transporter (ilt) family

Names & Taxonomyi

Protein namesi
Recommended name:
Putative inactive ferrous iron permease EfeU
Alternative name(s):
Putative Fe(2+) ion permease EfeU
Gene namesi
Name:efeU
Synonyms:ycdN
Ordered Locus Names:b4490, JW5141/JW1002
ORF Names:b1016/b1017
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13860 efeU

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1PeriplasmicSequence analysis1
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Topological domaini23 – 35CytoplasmicSequence analysisAdd BLAST13
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Topological domaini57 – 69PeriplasmicSequence analysisAdd BLAST13
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Topological domaini91 – 118CytoplasmicSequence analysisAdd BLAST28
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 147PeriplasmicSequence analysis8
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Topological domaini169 – 179CytoplasmicSequence analysisAdd BLAST11
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Topological domaini201 – 244PeriplasmicSequence analysisAdd BLAST44
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 276CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001596521 – 276Putative inactive ferrous iron permease EfeUAdd BLAST276

Proteomic databases

PRIDEiP75901

Interactioni

Subunit structurei

Part of a ferrous iron transporter composed of EfeU, EfeO and EfeB. However, this EfeUOB tripartite iron transporter is defective in E.coli strain K12 due to a frameshift mutation in EfeU.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP75901
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000236918
InParanoidiP75901
PhylomeDBiP75901

Family and domain databases

InterProiView protein in InterPro
IPR005217 FTR1-like
IPR004923 FTR1/Fip1/EfeU
PANTHERiPTHR31632 PTHR31632, 1 hit
PfamiView protein in Pfam
PF03239 FTR1, 1 hit
TIGRFAMsiTIGR00145 TIGR00145, 1 hit

Sequencei

Sequence statusi: Complete.

P75901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVPFLIMLR EGLEAALIVS LIASYLKRTQ RGMXDCVMWI GVLLAAALCL
60 70 80 90 100
GLGIFINETT GEFPQKEQEL FEGIVAVIAV VILTWMVFWM RKVSRNVKVQ
110 120 130 140 150
LEQAVDSALQ RGNHHGWALV MMVFFAVARE GLESVFFLLA AFQQDVGIWP
160 170 180 190 200
PLGAMLGLAT AVVLGFLLYW GGIRLNLGAF FKWTSLFILF VAAGLAAGAI
210 220 230 240 250
RAFHEAGLWN HFQEIAFDMS AVLSTHSLFG TLMEGIFGYQ EAPSVSEVAV
260 270
WFIYLIPALV AFALPPRAGA TASRSA
Length:276
Mass (Da):30,292
Last modified:December 15, 1998 - v2
Checksum:i27FC648B7F791AE7
GO

Sequence cautioni

The sequence AP009048 differs from that shown. Reason: Frameshift at position 34.Curated
The sequence U00096 differs from that shown. Reason: Frameshift at position 34.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA No translation available.
AP009048 Genomic DNA No translation available.

Similar proteinsi

Entry informationi

Entry nameiEFEU_ECOLI
AccessioniPrimary (citable) accession number: P75901
Secondary accession number(s): P75900, Q9R3S6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: May 23, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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