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Entry version 132 (02 Dec 2020)
Sequence version 2 (27 Apr 2001)
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Protein

Inner membrane protein YccS

Gene

yccS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:G6495-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.85.1.1, the aromatic acid exporter (arae) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inner membrane protein YccS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:yccS
Ordered Locus Names:b0960, JW5128
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 10PeriplasmicSequence analysis10
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32CytoplasmicSequence analysis1
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 66PeriplasmicSequence analysisAdd BLAST13
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Topological domaini88CytoplasmicSequence analysis1
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 112PeriplasmicSequence analysis3
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Topological domaini134 – 142CytoplasmicSequence analysis9
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 398PeriplasmicSequence analysisAdd BLAST235
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 441CytoplasmicSequence analysisAdd BLAST22
Transmembranei442 – 462HelicalSequence analysisAdd BLAST21
Topological domaini463 – 465PeriplasmicSequence analysis3
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
Topological domaini487 – 489CytoplasmicSequence analysis3
Transmembranei490 – 510HelicalSequence analysisAdd BLAST21
Topological domaini511 – 512PeriplasmicSequence analysis2
Transmembranei513 – 533HelicalSequence analysisAdd BLAST21
Topological domaini534 – 717CytoplasmicSequence analysisAdd BLAST184

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001687931 – 717Inner membrane protein YccSAdd BLAST717

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P75870

PRoteomics IDEntifications database

More...
PRIDEi
P75870

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4263155, 284 interactors

Database of interacting proteins

More...
DIPi
DIP-11498N

Protein interaction database and analysis system

More...
IntActi
P75870, 1 interactor

STRING: functional protein association networks

More...
STRINGi
511145.b0960

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P75870

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the YccS/YhfK family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1289, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013315_1_0_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P75870

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P75870

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010019, Integral_membrane_YccS
IPR010020, Integral_membrane_YCCS_YHJK
IPR032692, YccS_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12805, FUSC-like, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01666, YCCS, 1 hit
TIGR01667, YCCS_YHJK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P75870-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSPLLKRYT WNSAWLYYAR IFIALCGTTA FPWWLGDVKL TIPLTLGMVA
60 70 80 90 100
AALTDLDDRL AGRLRNLIIT LFCFFIASAS VELLFPWPWL FAIGLTLSTS
110 120 130 140 150
GFILLGGLGQ RYATIAFGAL LIAIYTMLGT SLYEHWYQQP MYLLAGAVWY
160 170 180 190 200
NVLTLIGHLL FPVRPLQDNL ARCYEQLARY LELKSRMFDP DIEDQSQAPL
210 220 230 240 250
YDLALANGLL MATLNQTKLS LLTRLRGDRG QRGTRRTLHY YFVAQDIHER
260 270 280 290 300
ASSSHIQYQT LREHFRHSDV LFRFQRLMSM QGQACQQLSR CILLRQPYQH
310 320 330 340 350
DPHFERAFTH IDAALERMRD NGAPADLLKT LGFLLNNLRA IDAQLATIES
360 370 380 390 400
EQAQALPHNN DENELADDSP HGLSDIWLRL SRHFTPESAL FRHAVRMSLV
410 420 430 440 450
LCFGYAIIQI TGMHHGYWIL LTSLFVCQPN YNATRHRLKL RIIGTLVGIA
460 470 480 490 500
IGIPVLWFVP SLEGQLVLLV ITGVLFFAFR NVQYAHATMF ITLLVLLCFN
510 520 530 540 550
LLGEGFEVAL PRVIDTLIGC AIAWAAVSYI WPDWQFRNLP RMLERATEAN
560 570 580 590 600
CRYLDAILEQ YHQGRDNRLA YRIARRDAHN RDAELASVVS NMSSEPNVTP
610 620 630 640 650
QIREAAFRLL CLNHTFTSYI SALGAHREQL TNPEILAFLD DAVCYVDDAL
660 670 680 690 700
HHQPADEERV NEALASLKQR MQQLEPRADS KEPLVVQQVG LLIALLPEIG
710
RLQRQITQVP QETPVSA
Length:717
Mass (Da):81,668
Last modified:April 27, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8EC99A6850EFAD5A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74046.2
AP009048 Genomic DNA Translation: BAA35718.2

Protein sequence database of the Protein Information Resource

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PIRi
G64836

NCBI Reference Sequences

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RefSeqi
NP_415480.2, NC_000913.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC74046; AAC74046; b0960
BAA35718; BAA35718; BAA35718

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
947001

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW5128
eco:b0960

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|511145.12.peg.994

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74046.2
AP009048 Genomic DNA Translation: BAA35718.2
PIRiG64836
RefSeqiNP_415480.2, NC_000913.3

3D structure databases

SMRiP75870
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4263155, 284 interactors
DIPiDIP-11498N
IntActiP75870, 1 interactor
STRINGi511145.b0960

Protein family/group databases

TCDBi2.A.85.1.1, the aromatic acid exporter (arae) family

Proteomic databases

PaxDbiP75870
PRIDEiP75870

Genome annotation databases

EnsemblBacteriaiAAC74046; AAC74046; b0960
BAA35718; BAA35718; BAA35718
GeneIDi947001
KEGGiecj:JW5128
eco:b0960
PATRICifig|511145.12.peg.994

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB3485

Phylogenomic databases

eggNOGiCOG1289, Bacteria
HOGENOMiCLU_013315_1_0_6
InParanoidiP75870
PhylomeDBiP75870

Enzyme and pathway databases

BioCyciEcoCyc:G6495-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P75870

Family and domain databases

InterProiView protein in InterPro
IPR010019, Integral_membrane_YccS
IPR010020, Integral_membrane_YCCS_YHJK
IPR032692, YccS_N
PfamiView protein in Pfam
PF12805, FUSC-like, 1 hit
TIGRFAMsiTIGR01666, YCCS, 1 hit
TIGR01667, YCCS_YHJK, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYCCS_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P75870
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 27, 2001
Last modified: December 2, 2020
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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