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UniProtKB - P75838 (YCAO_ECOLI)
Protein
Ribosomal protein S12 methylthiotransferase accessory factor YcaO
Gene
ycaO
Organism
Escherichia coli (strain K12)
Status
Functioni
Involved in beta-methylthiolation of ribosomal protein S12.
1 PublicationGO - Molecular functioni
- ATP diphosphatase activity Source: EcoCyc
- magnesium ion binding Source: EcoCyc
GO - Biological processi
- peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid Source: EcoCyc
Enzyme and pathway databases
BioCyci | EcoCyc:G6468-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Ribosomal protein S12 methylthiotransferase accessory factor YcaO |
Gene namesi | Name:ycaO Ordered Locus Names:b0905, JW0888 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Mutant shows a decrease in the ratio of methylthiolated to unmodified S12 and a decrease in transcription of a subset of genes.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144976 | 1 – 586 | Ribosomal protein S12 methylthiotransferase accessory factor YcaOAdd BLAST | 586 |
Proteomic databases
jPOSTi | P75838 |
PaxDbi | P75838 |
PRIDEi | P75838 |
Interactioni
Subunit structurei
Interacts with the ribosomal small subunit.
1 PublicationProtein-protein interaction databases
BioGRIDi | 4260837, 37 interactors |
DIPi | DIP-11470N |
IntActi | P75838, 8 interactors |
STRINGi | 511145.b0905 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P75838 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 60 – 437 | YcaOPROSITE-ProRule annotationAdd BLAST | 378 |
Phylogenomic databases
eggNOGi | COG1944, Bacteria |
HOGENOMi | CLU_022530_1_0_6 |
InParanoidi | P75838 |
PhylomeDBi | P75838 |
Family and domain databases
InterProi | View protein in InterPro IPR003776, YcaO-like_dom IPR041080, YcaO_C |
Pfami | View protein in Pfam PF02624, YcaO, 1 hit PF18381, YcaO_C, 1 hit |
TIGRFAMsi | TIGR00702, TIGR00702, 1 hit |
PROSITEi | View protein in PROSITE PS51664, YCAO, 1 hit |
i Sequence
Sequence statusi: Complete.
P75838-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTQTFIPGKD AALEDSIARF QQKLSDLGFQ IEEASWLNPV PNVWSVHIRD
60 70 80 90 100
KECALCFTNG KGATKKAALA SALGEYFERL STNYFFADFW LGETIANGPF
110 120 130 140 150
VHYPNEKWFP LTENDDVPEG LLDDRLRAFY DPENELTGSM LIDLQSGNED
160 170 180 190 200
RGICGLPFTR QSDNQTVYIP MNIIGNLYVS NGMSAGNTRN EARVQGLSEV
210 220 230 240 250
FERYVKNRII AESISLPEIP ADVLARYPAV VEAIETLEAE GFPIFAYDGS
260 270 280 290 300
LGGQYPVICV VLFNPANGTC FASFGAHPDF GVALERTVTE LLQGRGLKDL
310 320 330 340 350
DVFTPPTFDD EEVAEHTNLE THFIDSSGLI SWDLFKQDAD YPFVDWNFSG
360 370 380 390 400
TTEEEFATLM AIFNKEDKEV YIADYEHLGV YACRIIVPGM SDIYPAEDLW
410 420 430 440 450
LANNSMGSHL RETILSLPGS EWEKEDYLNL IEQLDEEGFD DFTRVRELLG
460 470 480 490 500
LATGSDNGWY TLRIGELKAM LALAGGDLEQ ALVWTEWTME FNSSVFSPER
510 520 530 540 550
ANYYRCLQTL LLLAQEEDRQ PLQYLNAFVR MYGADAVEAA SAAMSGEAAF
560 570 580
YGLQPVDSDL HAFAAHQSLL KAYEKLQRAK AAFWAK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73991.2 AP009048 Genomic DNA Translation: BAA35640.2 |
PIRi | H64829 |
RefSeqi | NP_415425.4, NC_000913.3 WP_001295344.1, NZ_SSZK01000002.1 |
Genome annotation databases
EnsemblBacteriai | AAC73991; AAC73991; b0905 BAA35640; BAA35640; BAA35640 |
GeneIDi | 66670819 945509 |
KEGGi | ecj:JW0888 eco:b0905 |
PATRICi | fig|1411691.4.peg.1371 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73991.2 AP009048 Genomic DNA Translation: BAA35640.2 |
PIRi | H64829 |
RefSeqi | NP_415425.4, NC_000913.3 WP_001295344.1, NZ_SSZK01000002.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4Q84 | X-ray | 2.64 | A/B | 1-586 | [»] | |
4Q85 | X-ray | 3.29 | A/B/C/D/E/F/G/H | 1-586 | [»] | |
4Q86 | X-ray | 2.25 | A/B/C/D/E/F/G/H | 1-586 | [»] | |
SMRi | P75838 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4260837, 37 interactors |
DIPi | DIP-11470N |
IntActi | P75838, 8 interactors |
STRINGi | 511145.b0905 |
Proteomic databases
jPOSTi | P75838 |
PaxDbi | P75838 |
PRIDEi | P75838 |
Genome annotation databases
EnsemblBacteriai | AAC73991; AAC73991; b0905 BAA35640; BAA35640; BAA35640 |
GeneIDi | 66670819 945509 |
KEGGi | ecj:JW0888 eco:b0905 |
PATRICi | fig|1411691.4.peg.1371 |
Organism-specific databases
EchoBASEi | EB3463 |
Phylogenomic databases
eggNOGi | COG1944, Bacteria |
HOGENOMi | CLU_022530_1_0_6 |
InParanoidi | P75838 |
PhylomeDBi | P75838 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6468-MONOMER |
Miscellaneous databases
PROi | PR:P75838 |
Family and domain databases
InterProi | View protein in InterPro IPR003776, YcaO-like_dom IPR041080, YcaO_C |
Pfami | View protein in Pfam PF02624, YcaO, 1 hit PF18381, YcaO_C, 1 hit |
TIGRFAMsi | TIGR00702, TIGR00702, 1 hit |
PROSITEi | View protein in PROSITE PS51664, YCAO, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | YCAO_ECOLI | |
Accessioni | P75838Primary (citable) accession number: P75838 Secondary accession number(s): Q9R2W0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | December 15, 1998 | |
Last modified: | February 23, 2022 | |
This is version 140 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references