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Entry version 136 (13 Nov 2019)
Sequence version 2 (30 May 2000)
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Protein

Inner membrane transporter YcaM

Gene

ycaM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:YCAM
ECOL316407:JW5119-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.3.7.2 the amino acid-polyamine-organocation (apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inner membrane transporter YcaM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ycaM
Ordered Locus Names:b0899, JW5119
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9CytoplasmicSequence analysis9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 38PeriplasmicSequence analysis8
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 80CytoplasmicSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 125PeriplasmicSequence analysisAdd BLAST24
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Topological domaini147 – 154CytoplasmicSequence analysis8
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 195PeriplasmicSequence analysisAdd BLAST20
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 240CytoplasmicSequence analysisAdd BLAST24
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 291PeriplasmicSequence analysisAdd BLAST30
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Topological domaini313 – 343CytoplasmicSequence analysisAdd BLAST31
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 375PeriplasmicSequence analysisAdd BLAST11
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Topological domaini397 – 414CytoplasmicSequence analysisAdd BLAST18
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Topological domaini436 – 448PeriplasmicSequence analysisAdd BLAST13
Transmembranei449 – 469HelicalSequence analysisAdd BLAST21
Topological domaini470 – 476CytoplasmicSequence analysis7

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002130441 – 476Inner membrane transporter YcaMAdd BLAST476

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P75835

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P75835

PRoteomics IDEntifications database

More...
PRIDEi
P75835

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4261113, 109 interactors

Database of interacting proteins

More...
DIPi
DIP-11468N

STRING: functional protein association networks

More...
STRINGi
511145.b0899

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105E5D Bacteria
COG0531 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000057650

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P75835

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P75835

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002293 AA/rel_permease1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13520 AA_permease_2, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006060 AA_transporter, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P75835-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGNVQEKQL RWYNIALMSF ITVWGFGNVV NNYANQGLVV VFSWVFIFAL
60 70 80 90 100
YFTPYALIVG QLGSTFKDGK GGVSTWIKHT MGPGLAYLAA WTYWVVHIPY
110 120 130 140 150
LAQKPQAILI ALGWAMKGDG SLIKEYSVVA LQGLTLVLFI FFMWVASRGM
160 170 180 190 200
KSLKIVGSVA GIAMFVMSLL YVAMAVTAPA ITEVHIATTN ITWETFIPHI
210 220 230 240 250
DFTYITTISM LVFAVGGAEK ISPYVNQTRN PGKEFPKGML CLAVMVAVCA
260 270 280 290 300
ILGSLAMGMM FDSRNIPDDL MTNGQYYAFQ KLGEYYNMGN TLMVIYAIAN
310 320 330 340 350
TLGQVAALVF SIDAPLKVLL GDADSKYIPA SLCRTNASGT PVNGYFLTLV
360 370 380 390 400
LVAILIMLPT LGIGDMNNLY KWLLNLNSVV MPLRYLWVFV AFIAVVRLAQ
410 420 430 440 450
KYKPEYVFIR NKPLAMTVGI WCFAFTAFAC LTGIFPKMEA FTAEWTFQLA
460 470
LNVATPFVLV GLGLIFPLLA RKANSK
Length:476
Mass (Da):52,496
Last modified:May 30, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEEE28BE119576B21
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73985.2
AP009048 Genomic DNA Translation: BAA35634.2

Protein sequence database of the Protein Information Resource

More...
PIRi
B64829

NCBI Reference Sequences

More...
RefSeqi
NP_415419.2, NC_000913.3
WP_000918506.1, NZ_SSZK01000002.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC73985; AAC73985; b0899
BAA35634; BAA35634; BAA35634

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
945518

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW5119
eco:b0899

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.1377

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73985.2
AP009048 Genomic DNA Translation: BAA35634.2
PIRiB64829
RefSeqiNP_415419.2, NC_000913.3
WP_000918506.1, NZ_SSZK01000002.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi4261113, 109 interactors
DIPiDIP-11468N
STRINGi511145.b0899

Protein family/group databases

TCDBi2.A.3.7.2 the amino acid-polyamine-organocation (apc) family

Proteomic databases

jPOSTiP75835
PaxDbiP75835
PRIDEiP75835

Genome annotation databases

EnsemblBacteriaiAAC73985; AAC73985; b0899
BAA35634; BAA35634; BAA35634
GeneIDi945518
KEGGiecj:JW5119
eco:b0899
PATRICifig|1411691.4.peg.1377

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB3461

Phylogenomic databases

eggNOGiENOG4105E5D Bacteria
COG0531 LUCA
HOGENOMiHOG000057650
InParanoidiP75835
PhylomeDBiP75835

Enzyme and pathway databases

BioCyciEcoCyc:YCAM
ECOL316407:JW5119-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P75835

Family and domain databases

InterProiView protein in InterPro
IPR002293 AA/rel_permease1
PfamiView protein in Pfam
PF13520 AA_permease_2, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYCAM_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P75835
Secondary accession number(s): Q9R7Q7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 13, 2019
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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